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Keywords: ICRF-193
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Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

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Cardiovascular-Oncology
Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš, Nela Váňová, Yvona Mazurová, Michaela Adamcová, Anna Jirkovská, Magdalena Holečková, Tomáš Šimůnek, Petra Štěrbová-Kovaříková, Jaroslav Roh, Martin Štěrba
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1897–1914.
https://doi.org/10.1042/CS20210311
Published: 10 August 2021
... representative of the class. The present study used a rabbit model of chronic ANT cardiotoxicity to examine another bisdioxopiperazine compound called GK-667 ( meso -(butane-2,3-diylbis(2,6-dioxopiperazine-4,1-diyl))bis(methylene)-bis(2-aminoacetate) hydrochloride), a water-soluble prodrug of ICRF-193 ( meso...
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Includes: Supplementary data