... Attribution License 4.0 (CC BY) . COVID-19 flow cytometry immunology immunometabolism innate immunity NK cells type 2 diabetes In 2021, 529 million people worldwide have diabetes, with type 2 diabetes (T2D) representing a staggering 96% of these cases [ 1 ]. T2D is marked by insulin...

... Limited on behalf of the Biochemical Society 2024 aging astrocytes glial cell immunometabolism neurodegeneration obesity National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs) 501100010757 NC/X000923/1 University of Exeter 501100000737...

... Immunometabolism Leucocyte Lymphocytes are produced in bone marrow with maturation in the thymus for T (thymus-derived) cells or in the bone marrow itself in the case of B cells ( b ursal or b one marrow-derived). Each of these populations can be subdivided into cells with different characteristics...

...Maria J. Forteza; Daniel F.J. Ketelhuth Over the last decade, there has been a growing interest to understand the link between metabolism and the immune response in the context of metabolic diseases but also beyond, giving then birth to a new field of research. Termed ‘immunometabolism...

... is implicated in the pathogenesis of many human diseases, including allergy, chronic inflammation and cancer. In this review, we aim to introduce the reader to the field of cholesterol immunometabolism and discuss how both metabolites arising from the pathway and cholesterol homeostasis are able to impact...

..., similar to those induced by microbial products or high cholesterol diets in mice, may help to explain the chronic inflammatory state driving atherosclerosis and cardiovascular risk that exists for patients with diabetes despite improved metabolic control. From an immunometabolic perspective, we speculate...