... the possibility of therapeutic interventions. Currently there is no reliable clinical method for assessing the severity of hepatic ischaemic injury. The hepatic handling of Indocyanine Green as a technique for monitoring the severity of I/R injury has been investigated in the present study. A rabbit model...

... in systemic haemodynamics and fibrinolytic parameters. The increase in portal blood flow was not reflected in significant changes in Indocyanine Green clearance. It appears that the Indocyanine Green method is relatively insensitive to increases in liver blood flow. 6. The observed increase in fibrinolytic...

...David F. Kisor; Reginald F. Frye; Kenneth A. Kudsk 1. The hepatic extraction ratio of Indocyanine Green was measured directly by trans-hepatic catheterization in 14 outbred swine (eight well-fed, six malnourished). A specific two-compartment pharmacokinetic model was fitted to the arterial...

...E. Burns; D. R. Triger; G. T. Tucker; N. D. S. Bax 1. The validity of a two-compartment pharmacokinetic model for the estimation of the hepatic extraction ratio of Indocyanine Green was tested in six patients with cirrhosis of the liver. 2. No agreement was found between the value of the hepatic...

...E. Burns; C. E. Ball; J. P. Christie; G. D. Broadhead; G. T. Tucker; N. D. S. Bax 1. In order to estimate liver blood flow in the rat, the extraction ratio of Indocyanine Green was determined using a two-compartment model fitted to the plasma concentration time data after a single intravenous bolus...

... by decreasing the ‘indirect’ fraction to 34.5% of pretreatment values. 2. In contrast to treatment with phenobarbitone, clofibrate did not change the ratio of bilirubin mono- to di-conjugates in bile. 3. The initial plasma disappearance rate of indocyanine green and of bromosulphophthalein did not show...

...S. L. Grainger; P. W. N. Keeling; I. M. H. Brown; J. H. Marigold; R. P. H. Thompson 1. The disposition of an intravenous bolus of indocyanine green (ICG) has been studied in healthy man and baboons using a novel analysis of a two compartment pharmacokinetic model. 2. This analysis enabled...

...J. H. Marigold; I. T. Gilmore; R. P. H. Thompson 1. The fasting plasma disappearance curve of [ 14 C]glycocholic acid after intravenous injection was compared in nine normal subjects with that obtained 100 min after a standard liquid test meal. 2. Plasma disappearance curves of indocyanine green...