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Keywords: Inflammation
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Articles
Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
... generally accepted that inflammation is commonly involved in the pathogenesis. Ongoing inflammatory responses exacerbate liver injury, or even result in fibrosis and cirrhosis. Here we report that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, exerts beneficial effects on acute and chronic liver...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge on...
Articles
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β and...
Articles
Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF This...
Articles
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
Articles
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
Published: 21 December 2020
... hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics...
Articles
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
... attenuating effects of AT 2 R agonists on pulmonary inflammation will presumably have a preventive effect with regard to the development of pulmonary fibrosis in patients with a severe, hyperinflammatory courses of COVID-19 [ 26 , 82 , 97 ]. However, this assumption will have to be proven in future clinical...
Articles
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
... volume. Correspondence: Gavin Y. Oudit ( gavin.oudit@ualberta.ca ) 02 09 2020 15 09 2020 17 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 adipose tissue inflammation Maternal programming obesity...
Articles
Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF The...
Articles
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
... characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves...
Articles
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
Published: 23 July 2020
... alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (14): 1957–1971.
Published: 23 July 2020
... assess the underlying mechanisms. We found that α 2A -AR deficiency decreased the permeability of the alveolar capillary barrier in ARDS mice and suppressed lung inflammation by reducing inflammatory cell infiltration and the production of TNF-α, interleukin (IL)-6, and CXCL2/MIP-2. LPS stimulation...
Articles
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
... death. Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury...
Articles
Clin Sci (Lond) (2020) 134 (13): 1679–1696.
Published: 07 July 2020
.... NE pharmacological inhibitor (sivelestat) or biological inhibitor (elafin) was supplemented into NOD mice to evaluate their effects on islet inflammation and diabetogenesis. The impact of NE inhibition on innate and adaptive immune cells was measured with flow cytometry and immunohistochemistry. A...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
...-CD32-NF-κB pathway may represent a novel therapeutic strategy for DR. angiogenesis c-reactive protein diabetic retinopathy inflammation oxidative stress retinal degeneration Diabetic retinopathy (DR) is the leading cause of vision loss in working-age people in developed countries [ 1...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... experimental studies also demonstrate that KD025 has potent therapeutic effects in inflammatory disorders [ 24 ], adipogenesis [ 25 ], and focal cerebral ischemia [ 26 ], indicating KD025 regulates inflammation, metabolism and is protective to cellular injury. The effect of KD025 on the progression of...
Articles
Clin Sci (Lond) (2020) 134 (12): 1433–1448.
Published: 18 June 2020
...Simeng Liu; Zhimin Huang; Anna Tang; Xiaoqing Wu; Jeffrey Aube; Liang Xu; Changying Xing; Yufeng Huang Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is...
Articles
Clin Sci (Lond) (2020) 134 (12): 1319–1331.
Published: 16 June 2020
... 2020 18 05 2020 19 05 2020 aldosterone cardiac remodeling inflammation microRNA-34a TRIF Cardiac pathophysiological remodeling is one of the major characteristics in the development of heart failure. There has been a sustained effort to develop novel strategies to...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (11): 1191–1218.
Published: 03 June 2020
.... eosinophils inflammation Interleukin 33 myocardial infarction ST2 ventricular remodeling Cardiovascular diseases, primarily acute myocardial infarction (MI) and stroke, represent the leading cause of mortality in the Western world and are on the rise in developing countries. Despite improved...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (6): 571–592.
Published: 18 March 2020
... peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (5): 439–458.
Published: 04 March 2020
... distributed under the Creative Commons Attribution License 4.0 (CC BY) . atherosclerosis inflammation lipid uptake sphingolipid inhibitors Atherosclerosis is the fundamental pathological process underlying cardio-cerebral vascular diseases (CVDs), which are the leading cause of morbidity and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 273–287.
Published: 29 January 2020
... IFN-γ by increasing liver X receptor (LXR)-β levels. Furthermore, the degree of CpG island methylation in the SULT2B1b promoter was reduced in cells from AMI patients. In conclusion, SULT2B1b up-regulation due to hypomethylation of its promoter promotes cholesterol accumulation and inflammation by...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 139–154.
Published: 23 January 2020
.... 25 09 2019 04 01 2020 13 01 2020 13 01 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Acute kidney injury circ-0114427 circular RNA inflammation next-generation sequencing Acute kidney injury (AKI) is a...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (1): 15–32.
Published: 03 January 2020
... Fibroblast growth factor 23 (FGF23) increases phosphorus excretion and decreases calcitriol (1,25(OH) 2 D) levels. FGF23 increases from early stages of renal failure. We evaluated whether strict control of phosphorus intake in renal failure prevents the increase in FGF23 and to what extent inflammation...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (1): 3–13.
Published: 03 January 2020
... to promote inflammation and angiogenesis, and PVAT phenotypic changes occurring in the setting of obesity, hyperlipidemia etc., are fundamentally important in determining a pathogenic versus protective role of PVAT in vascular disease. Recent discoveries have advanced our understanding of the role of...
Articles
Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
...Ratana Lim; Caitlyn Nguyen-Ngo; Martha Lappas Preterm birth is a global healthcare challenge. Spontaneous preterm birth (sPTB) is commonly caused by inflammation, yet there are currently no effective therapies available. The Bromodomain and Extra-Terminal motif (BET) proteins, Bromodomain...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2345–2360.
Published: 28 November 2019
...-3 FA levels, mainly docosahexaenoic acid (DHA), in comparison with WT mice. FAT-1 mice had increased myeloperoxidase (MPO) activity and content of CXCL-1 and CXCL-2, and reduced IL-10 in the skin wound tissue three days after the wound induction. Inflammation was maintained by an elevated TNF-α...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2283–2299.
Published: 21 November 2019
...Apabrita Ayan Das; Devasmita Chakravarty; Debmalya Bhunia; Surajit Ghosh; Prakash C. Mandal; Khawer N. Siddiqui; Arun Bandyopadhyay The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
... and concerted action of factors that contribute to the development of liver inflammation and eventually fibrosis. Here, we summarize fundamental molecular mechanisms underlying the pathogenesis of non-alcoholic steatohepatitis (NASH), how they are interrelated and possible translation to clinical...
Articles
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
.... Genetic disorders and insulin receptor disorders, environmental factors, lifestyle choices and toxins are key factors that contribute to DM. While it is often referred to as a metabolic disorder, modern lifestyle choices and nutrient excess induce a state of systemic chronic inflammation that results in...
Articles
Clin Sci (Lond) (2019) 133 (20): 2061–2067.
Published: 18 October 2019
.... Correspondence: Niwanthi Rajapakse ( n.rajapakse@uq.edu.au ) 22 08 2019 22 08 2019 16 09 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 arterial stiffness inflammation nitric oxide renal sympathetic nerves resistant...
Articles
Clin Sci (Lond) (2019) 133 (20): 2045–2059.
Published: 16 October 2019
...Da Zhang; Xiuli Wang; Siyao Chen; Selena Chen; Wen Yu; Xin Liu; Guosheng Yang; Yinghong Tao; Xinjing Tang; Dingfang Bu; Heng Zhang; Wei Kong; Chaoshu Tang; Yaqian Huang; Junbao Du; Hongfang Jin Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1663–1703.
Published: 25 July 2019
... Singh Sohal ( sssohal@utas.edu.au ) 18 03 2019 27 06 2019 28 06 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 COPD exacerbation infection inflammation Chronic respiratory diseases are among the leading...
Articles
Clin Sci (Lond) (2019) 133 (14): 1609–1627.
Published: 25 July 2019
... ischemic reperfusion, nephrotoxic drugs and sepsis. It is characterized by a sudden decline in renal function, in addition to excessive inflammation, oxidative stress and programmed cell death of renal tubular epithelial cells. RIPK1-mediated necroptosis plays an important role in AKI. In the present study...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
... wall, monocyte differentiation to macrophages and uptake of oxidized low density lipoprotein. Macrophage activation and inflammatory cytokine production are major factors which drive ongoing inflammation and plaque development. Identification of novel pathways driving this on-going inflammatory process...
Articles
Clin Sci (Lond) (2019) 133 (14): 1537–1548.
Published: 17 July 2019
...: Soluble ST2 (interleukin 1 receptor-like 1) (sST2) is involved in inflammatory diseases and increased in heart failure (HF). We herein investigated sST2 effects on oxidative stress and inflammation in human cardiac fibroblasts and its pathological role in human aortic stenosis (AS). Methods and results...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (12): 1321–1339.
Published: 20 June 2019
... basement membrane, mesangiolysis and mesangial expansion, extracellular matrix (ECM) accumulation, arteriosclerosis, podocytes injury and tubulopathy. A multitude of additional pathogenic processes are also implicated, including inflammation, advanced glycation end product (AGE) accumulation, oxidative...
Articles
Clin Sci (Lond) (2019) 133 (12): 1309–1320.
Published: 19 June 2019
...–mesenchymal transition, and suppression of inflammation and angiogenesis. In this article, we summarize the mechanisms and efficacy of nintedanib in the treatment of fibrotic diseases in animal models and clinical trials, provide an update on recent advances in the development of other novel antifibrotic...
Articles
Clin Sci (Lond) (2019) 133 (12): 1297–1308.
Published: 19 June 2019
... © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 bone loss Granulocyte colony-stimulating factor inflammation Staphylococcus aureus Osteomyelitis, a persistent infection of bone tissue, is characterized by severe inflammation and...
Articles
Clin Sci (Lond) (2019) 133 (10): 1185–1196.
Published: 30 May 2019
... inflammation exacerbates atherosclerosis, but the possible effect of intrauterine inflammation is largely unexplored. Exposure to inflammation in utero is common, especially in infants born preterm, who have increased cardiovascular risk in adulthood. We hypothesised that exposure to inflammation before birth...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (8): 997–1010.
Published: 29 April 2019
... Inflammation MS-based metabolomics NMR-based lipoprotein profile Poor immune recovery Combined antiretroviral therapy (cART) successfully controls HIV viremia and improves the prognosis of HIV-infected subjects due to the decrease in HIV replication below detectable levels and due to CD4 + T-cell...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (7): 789–804.
Published: 02 April 2019
... that ANXA2 also played a critical role in bleomycin-induced inflammation, which represents another major cause of bleomycin-induced pulmonary fibrosis. We found that bleomycin could induce the cell surface translocation of ANXA2 in lung epithelial cells through exosomal secretion, associated with...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (6): 741–760.
Published: 19 March 2019
... considerable amounts of proinflammatory cytokines to mediate and maintain the autoimmune responses in the liver [ 87 , 89–91 ]. autoimmunity cirrhosis immunology inflammation primary biliary cholangitis Primary biliary cholangitis (PBC) is an autoimmune disease that shares features with...
Articles
Clin Sci (Lond) (2019) 133 (2): 321–334.
Published: 25 January 2019
... regulating lung permeability and vascular inflammation is unknown. Here, the role of Poldip2 in regulating vascular permeability and inflammation in a mouse model of ARDS was assessed. Heterozygous deletion of Poldip2 was found to reduce LPS-induced mortality within 20 h, lung inflammatory signaling, and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (1): 135–148.
Published: 11 January 2019
...Wenxue Huang; Yalin Zhan; Yunfei Zheng; Ye Han; Wenjie Hu; Jianxia Hou Objective: Ferritin, an iron-binding protein, is ubiquitous and highly conserved; it plays a crucial role in inflammation, which is the main symptom of periodontitis. Full-length cDNA library analyses have demonstrated abundant...
Articles
Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
... may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy. DN can be considered the result of the interactions between multiple metabolic and haemodynamic factors that activate common intracellular signalling pathways, such as protein...
Articles
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... from earlier revascularisation. Nowadays, different biomarkers of plaque instability have been unravelled, among these miRNAs are promising tools for the diagnosis and treatment of atherosclerosis. Inflammation, reactive oxygen species (ROS) and endothelial dysfunction play a key role in unstable...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2387–2389.
Published: 19 November 2018
...Michael Weis The gut microbiome functions like an endocrine organ, generating enzymes and bioactive metabolites, which affect host physiology. In addition metabolism-independent processes like impaired intestinal barrier function may result in bacterial translocation and an increased inflammation...
Articles
Clin Sci (Lond) (2018) 132 (20): 2241–2259.
Published: 29 October 2018
... de novo inflammatory cytokines, chemokines, lipid mediators, and growth factors. However, the mechanisms by which MCs interact with other leukocytes to mediate inflammation or tissue injury are unknown at present [ 7 ]. In addition, MCs regulate vascular function and pathological changes by...
Includes: Supplementary data