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1-50 of 335
Keywords: Inflammation
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Articles
Roberto Palacios-Ramirez, Matthieu Soulié, Amaya Fernandez-Celis, Toshifumi Nakamura, Nabiha Boujardine, Benjamin Bonnard, Krister Bamberg, Natalia Lopez-Andres, Frederic Jaisser
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (16): 1025–1038.
Published: 22 August 2024
... CKD mouse model combining nephron reduction and a 60% high-fat diet. Balcinrenone and eplerenone prevented the progression of renal damages, extracellular matrix remodeling and inflammation to a similar extent. We identified a novel mechanism linking MR activation to the renal proteoglycan deposition...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (16): 989.
Published: 14 August 2024
... © 2024 The Author(s). 2024 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . complement dementia inflammation The authors of the review article...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (13): 817–850.
Published: 26 June 2024
... muscle cells, pericytes or other vascular wall cells underlie remodelling. In addition, immune cells, including macrophages and lymphocytes, may infiltrate vessels and initiate inflammatory signalling. They contribute to a dynamic interplay between cell proliferation, apoptosis, migration, inflammation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (12): 757–760.
Published: 19 June 2024
... in Figure 2 , Figure 4 , and Figure 7 of this paper with a β-actin panel of another paper by San-Miguel et al, 2020 (DOI: 10.3945/jn.110.121525 ), which shares an author. chronic hepatitis C virus (HCV) infection inflammation lipogenesis liver X receptor (LXR) non-alcoholic fatty liver disease...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (7): 435–487.
Published: 04 April 2024
... characteristic of septic shock. Failure to control the infections exaggerates inflammation which causes multi-organ dysfunction, tissue injury, and hypotension. Currently, norepinephrine is the first-line, and epinephrine and vasopressin remain the second-line, vasopressor therapy in septic shock [ 31 ]. Low...
Articles
Jacqui Nimmo, Robert A.J. Byrne, Nikoleta Daskoulidou, Lewis M. Watkins, Sarah M. Carpanini, Wioleta M. Zelek, B. Paul Morgan
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (6): 387–412.
Published: 20 March 2024
... are dependent in large part on properly regulated complement-mediated inflammation. Dysregulated complement activation, often driven by persistence of activating triggers, is a cause of pathological inflammation in numerous diseases, including neurological diseases. Increasingly, this has become apparent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (6): 351–369.
Published: 12 March 2024
... the signaling pathways involved in septic AKI using the mouse models of lipopolysaccharide (LPS) treatment and cecal ligation and puncture (CLP). In these models, renal inflammation and tubular cell apoptosis were accompanied by the aberrant activation of the mechanistic target of rapamycin (mTOR...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1665–1681.
Published: 15 November 2023
... for 1 h. Intensive chemiluminescence (BL523B, Biosharp, Anhui, China) was used to visualize the signal. Target protein expression levels were normalized to GAPDH. cardiac arrhythmia inflammation myocardial remodeling Sudden cardiac death (SCD) is a major life-threatening health problem...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1533–1545.
Published: 03 October 2023
... the phenotypic switching of vascular smooth muscle cells from a contractile to synthetic state during AAA. In addition, it was demonstrated that colchicine was able to reduce vascular inflammation, oxidative stress, cell pyroptosis and immune cells infiltration to the aortic wall in the AAA mice model. Finally...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (18): 1477–1498.
Published: 22 September 2023
... experiments, we found that Gpx3 might serve as a key gene for the regulation of selenomethionine in renal IRIs. Selenomethionine may exert a protective effect against renal IRI by up-regulating GPX3, inhibiting the MAPK signaling pathway, increased production of antioxidants, decreasing inflammation levels...
Articles
Nuria Dolade, Sandra Rayego-Mateos, Alicia Garcia-Carrasco, Maryse Guerin, Jose-Luis Martín-Ventura, Marta Ruiz-Ortega, Pierre-Louis Tharaux, Jose Manuel Valdivielso
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (17): 1409–1429.
Published: 13 September 2023
... year, (4) to have chronic inflammation or active infections or (5) to have undergone previous carotid artery surgery. The classification of patients in the different CKD stages due to their estimated GFR was based on the equations used in the modification of the diet in renal disease (MDRD4) [ 34...
Includes: Supplementary data
Articles
Sara Kazeminia, Xiang Y. Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Sandra M. Herrmann, Alejandro R. Chade, Maria V. Irazabal, Lilach O. Lerman, Alfonso Eirin
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1265–1283.
Published: 22 August 2023
..., and stroke, increasing cardiovascular morbidity and mortality [ 3 ]. Renal inflammation is an important determinant of renal injury and functional outcomes in RAS. Inflammatory cells, such as macrophages and T cells, infiltrate the stenotic kidney parenchyma and portend renal injury by producing...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1225–1247.
Published: 22 August 2023
... therapies. Inflammation has emerged as a potential contributor to the pathogenesis of HFpEF. Many of the risk factors for HFpEF are also associated with chronic inflammation, such as obesity, hypertension, aging, and renal dysfunction. A large amount of preclinical evidence suggests that immune cells...
Articles
Nima Yassini, Janine Sprenger, Eva Maria Pastor Arroyo, Christiane Krudewig, Giovanni Pellegrini, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (14): 1013–1025.
Published: 25 July 2023
... protein-coupled receptors that are stimulated upon increased extracellular acidity. These receptors have various physiological and pathophysiological roles in renal acid–base physiology, tissue inflammation, and fibrosis among others. Their function in injured renal tissue, however, remains mostly unclear...
Includes: Supplementary data
Articles
Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qin
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (12): 979–993.
Published: 28 June 2023
...Huahui Yu; Xiaolu Jiao; Yunyun Yang; Qianwen Lv; Zhiyong Du; Linyi Li; Chaowei Hu; Yunhui Du; Jing Zhang; Fan Li; Qiuju Sun; Yu Wang; Dong Chen; Xiaoping Zhang; Yanwen Qin Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell...
Includes: Supplementary data
Articles
Siddhi Jain, Pritam Saha, Nayadi Parambil Syamprasad, Samir Rajan Panda, Bishal Rajdev, Arun Kumar Jannu, Pawan Sharma, Vegi Ganga Modi Naidu
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (10): 785–805.
Published: 23 May 2023
... inflammation. Chlorogenic acid (CGA) has been shown to possess potent antioxidant, anti-inflammatory, and immunoprotective properties. However, the protective effect of CGA on viral and bacterial-induced ALI/ARDS is not yet explored. Hence, the current study is aimed to evaluate the preclinical efficacy of CGA...
Includes: Supplementary data
Articles
Rahul Kumar, Michael H. Lee, Biruk Kassa, Dara C. Fonseca Balladares, Claudia Mickael, Linda Sanders, Adam Andruska, Maya Kumar, Edda Spiekerkoetter, Angela Bandeira, Kurt R. Stenmark, Rubin M. Tuder, Brian B Graham
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (8): 617–631.
Published: 21 April 2023
... to the adventitial space, where these cells express thrombospondin-1 (TSP-1), which functionally activates TGF-β causing vascular remodeling [ 4 ]. While inflammation is a clear driver of schistosomiasis-PH, it is unclear how host inflammation evolves and contributes to the persistence of the PH disease after...
Includes: Supplementary data
Articles
Yvonne Baumer, Mario A. Pita, Andrew S. Baez, Lola R. Ortiz-Whittingham, Manuel A. Cintron, Rebecca R. Rose, Veronica C. Gray, Foster Osei Baah, Tiffany M. Powell-Wiley
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (6): 469–494.
Published: 24 March 2023
... of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
... with wild-type (WT) mice, Park7 -deficient mice experienced aggravated kidney tissue damage and dysfunction, and enhanced tubular apoptosis and inflammation following LPS treatment. Consistently, LPS-induced apoptosis and inflammation in renal tubular cells in vitro were exacerbated by Park7 knockdown...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (24): 1809–1829.
Published: 16 December 2022
... mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle...
Articles
Bethany L. Goodlett, Dakshnapriya Balasubbramanian, Shobana Navaneethabalakrishnan, Sydney E. Love, Emily M. Luera, Sunitha Konatham, Valorie L. Chiasson, Sophie Wedgeworth, Joseph M. Rutkowski, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
... 11 2022 08 11 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 hypertension immunity inflammation kidney lymphatics Hypertension (HTN), defined by the American Heart Association as having a blood pressure of 130/80...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... of adhesion molecules in the injured kidney. This, the authors speculate, may prevent inflammation from driving the functional decline of the kidney. Identifying these novel pathways represents an important step forward harnessing the potential benefits of alkali therapy in CKD. Correspondence: Paul M...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1257–1280.
Published: 05 September 2022
... overlapping pathophysiological mechanisms, inflammation and related factors, such as dysbiosis and insulin resistance, stand out. Besides underlying the association between psychiatric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets. cardiovascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (12): 1005–1017.
Published: 29 June 2022
..., including the slowing of CKD progression and a reduced risk of heart failure. 28 03 2022 01 06 2022 16 06 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 aldosterone fibrosis inflammation Chronic kidney...
Articles
Tom Macleod, Charles Bridgewood, Isabel Hyde, Megan Heague, Philip Helliwell, Martin Stacey, Miriam Wittmann
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (12): 935–952.
Published: 22 June 2022
...Tom Macleod; Charles Bridgewood; Isabel Hyde; Megan Heague; Philip Helliwell; Martin Stacey; Miriam Wittmann This review highlights the molecular and cellular mechanisms underlying psoriatic inflammation with an emphasis on recent developments which may impact on treatment approaches...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (10): 733–746.
Published: 24 May 2022
... to the pathogenesis of many chronic diseases, including asthma and chronic obstructive pulmonary disease (COPD). In asthma, increased autophagy plays a role in promoting type 2 immune responses and eosinophilic inflammation, whereas decreased autophagy may be important in neutrophilic asthma. Acute exposure...
Articles
Eva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
... ( [email protected] ) 09 02 2022 24 03 2022 07 04 2022 07 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 acid-base balance alkali therapy chronic kidney disease crystal nephropathy inflammation metabolism...
Includes: Supplementary data
Articles
Samer H. Barsom, Logan M. Glasstetter, Sarosh Siddiqi, Kamalnath Sankaran Rajagopalan, Alfonso Eirin, Lilach O. Lerman
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (3): 239–256.
Published: 07 February 2022
..., leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury...
Articles
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan, Mark E. Cooper, Karin Jandeleit-Dahm
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... the impact of NLRP3 inhibition on renal inflammation and associated pathology in DKD. We identified an adverse effect of MCC950 on renal pathology in diabetic animals. Indeed, MCC950-treated diabetic animals showed increased renal inflammation and macrophage infiltration in association with enhanced...
Includes: Supplementary data
Articles
Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 29–44.
Published: 05 January 2022
...Bo Wang; Chenguang Ding; Xiaoming Ding; Greg Tesch; Jin Zheng; PuYun Tian; Yang Li; Sharon Ricardo; Hsin-Hui Shen; Wujun Xue Inflammation is a pathological feature of kidney injury and its progression correlates with the development of kidney fibrosis which can lead to kidney function impairment...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (1): 61–80.
Published: 05 January 2022
...Manon Chauvin; Delphine Sauce Massive CD4 + T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many...
Articles
Koji Akita, Kikuo Isoda, Fumie Ohtomo, Sarasa Isobe, Tomiharu Niida, Yayoi Sato-Okabayashi, Motoaki Sano, Kazunori Shimada, Yoichiro Iwakura, Tohru Minamino
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
...Koji Akita; Kikuo Isoda; Fumie Ohtomo; Sarasa Isobe; Tomiharu Niida; Yayoi Sato-Okabayashi; Motoaki Sano; Kazunori Shimada; Yoichiro Iwakura; Tohru Minamino Clinical hypertension (HT) is associated with renal inflammation and elevated circulating levels of proinflammatory cytokines. Interleukin (IL...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (14): 1773–1789.
Published: 30 July 2021
..., inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high-fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ET A receptor antagonist, 10 mg/kg/day) or bosentan...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (13): 1563–1590.
Published: 07 July 2021
... inflammation in obese adipose tissue may contribute to the risk of developing insulin resistance and type 2 diabetes. Furthermore, increased vascular pro-inflammatory signalling is a key event in the development of cardiovascular diseases. Overnutrition exacerbates pro-inflammatory signalling in vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...
Articles
Yanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., it is generally accepted that inflammation is commonly involved in the pathogenesis. Ongoing inflammatory responses exacerbate liver injury, or even result in fibrosis and cirrhosis. Here we report that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, exerts beneficial effects on acute and chronic liver...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (6): 731–752.
Published: 17 March 2021
... change is the dysregulation of adipokine production. Adipokines are an indispensable link between metabolism and optimal immune system function; however, their dysregulation in obesity contributes to chronic low-grade inflammation and disease pathology. Herein, I will highlight current knowledge...
Articles
Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
.... Bothropstoxin-I (BthTX-I), from Bothrops jararacussu venom, is a K49-phospholipase A 2 (PLA 2 ) that induces a massive muscle tissue injury, and, consequently, local inflammatory reaction. The NLRP3 inflammasome is a sensor that triggers inflammation by activating caspase 1 and releasing interleukin (IL)-1β...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 229.
Published: 11 January 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 201–227.
Published: 08 January 2021
... indicates a link between disturbances in phosphate homeostasis and inflammation. The present review focuses on critical interactions of phosphate homeostasis, inflammation, vascular calcification and CVD. Especially, pro-inflammatory responses mediating hyperphosphatemia-related development of vascular...
Articles
Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Alexandra H. Lopez, Joseph M. Rutkowski, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (24): 3237–3257.
Published: 21 December 2020
... of hypertension on gonads in more detail on a molecular basis remain scarce. Hence, the aim of the current review is to address and summarize the effects of hypertension on reproductive health, and highlight the importance of research on the effects of hypertension on gonadal inflammation and lymphatics...
Articles
Xue-qi Liu, Ling Jiang, Lei Lei, Zhen-yong Nie, Wei Zhu, Sheng Wang, Han-xu Zeng, Shi-qi Zhang, Qiu Zhang, Benito Yard, Yong-gui Wu
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3175–3193.
Published: 09 December 2020
...Xue-qi Liu; Ling Jiang; Lei Lei; Zhen-yong Nie; Wei Zhu; Sheng Wang; Han-xu Zeng; Shi-qi Zhang; Qiu Zhang; Benito Yard; Yong-gui Wu Diabetic nephropathy (DN) is a common microvascular complication of diabetes and the main cause of end-stage nephropathy (ESRD). Inflammation and fibrosis play key...
Includes: Supplementary data
Articles
In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
,
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2987–3006.
Published: 19 November 2020
... treated with the AT 2 R agonist Compound 21 (C21). This trial has been completed, but results have not yet been reported. angiotensin converting enzyme 2 AT2 receptor COVID-19 inflammation The discovery in 2003 of angiotensin converting enzyme (ACE) 2 (ACE2) as the binding site and cellular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2447–2451.
Published: 25 September 2020
... pathogenic obesity in males and low-grade pathogenic obesity in females. adipose tissue inflammation Maternal programming obesity Childhood obesity is increasingly recognized as a pertinent global health concern, promoting a significant rise in morbidity in mortality including developing type...
Articles
Expression of Concern: TRIF/miR-34a mediates aldosterone-induced cardiac inflammation and remodeling
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 2053.
Published: 10 August 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . aldosterone cardiac remodeling inflammation microRNA-34a TRIF...
Articles
In Collection
Coronavirus
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
... the characteristic of being chronic degenerative diseases of inflammatory nature associated with defective heat shock response (HSR). The molecular components of the HSR, the principal metabolic pathway leading to the physiological resolution of inflammation, is an anti-inflammatory biochemical pathway that involves...
Articles
Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1935–1956.
Published: 23 July 2020
... in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation is associated with inflammation. Our preliminary screening results of macrophage methylation in the present study demonstrated the zinc finger SWI2/SNF2 and MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated in the 5...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (14): 1957–1971.
Published: 23 July 2020
... to assess the underlying mechanisms. We found that α 2A -AR deficiency decreased the permeability of the alveolar capillary barrier in ARDS mice and suppressed lung inflammation by reducing inflammatory cell infiltration and the production of TNF-α, interleukin (IL)-6, and CXCL2/MIP-2. LPS stimulation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1751–1762.
Published: 10 July 2020
.... Neutralization of HMGB1 attenuated IR-induced increases in plasma creatinine, blood urea nitrogen (BUN), inflammation, tubular damage and tubular cell death only in male SHR. In conclusion, our data demonstrate that there is a sex difference in the contribution of HMGB1 to IR-induced injury, where males exhibit...
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