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Keywords: Kidney
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Clin Sci (Lond) (2022) 136 (23): 1759–1772.
Published: 02 December 2022
... kidney-specific overexpression of VEGF-D (KidVD) experience renal lymphangiogenesis upon doxycycline administration. HTN was induced in KidVD+ and KidVD- mice by subcutaneous release of angiotensin II, administration of the nitric oxide synthase inhibitor L-NAME, or consumption of a 4% salt diet...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (12): 989–1003.
Published: 29 June 2022
... or/and activity of G-protein-coupled receptor kinase 4 (GRK4) or genetic variants (e.g., GRK4γ142V) cause sodium retention and hypertension. Whether GRK4 plays a role in the regulation of AT 2 R in the kidney remains unknown. In the present study, we found that spontaneously hypertensive rats (SHRs) had increased...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (22): 2575–2588.
Published: 26 November 2021
.... Treatment with tempol in paternal rats also reversed the increased expressions of AT 1 R and GRK4 in the kidney of their offspring. We suggest that paternal PM 2.5 exposure causes hypertension in offspring. The mechanism may be involved that paternal PM 2.5 exposure-associated oxidative stress induces...
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Clin Sci (Lond) (2021) 135 (21): 2521–2540.
Published: 09 November 2021
...) and recessive (AR) forms of polycystic kidney disease (PKD). We provide here a basic overview of the origins and clinical aspects of ARPKD and ADPKD and discuss the implications of electrolyte transport in cystogenesis. Special attention is devoted to intracellular calcium handling by the cystic cells...
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Clin Sci (Lond) (2021) 135 (17): 2165–2196.
Published: 17 September 2021
...Erika I. Boesen; Rahul M. Kakalij Hypertension is a major risk factor for cardiovascular disease, chronic kidney disease (CKD), and mortality. Troublingly, hypertension is highly prevalent in patients with autoimmune renal disease and hastens renal functional decline. Although progress has been...
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Clin Sci (Lond) (2020) 134 (22): 3023–3046.
Published: 24 November 2020
.... Abbreviations: IDA, iron deficiency anemia; RAS, renin angiotensin system; ROS, reactive oxygen species; RUPP, reduced uterine perfusion pressure. Cardiovascular Developmental programming Heart Kidney Vasculature The role of epigenetics in developmental programming has received...
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Clin Sci (Lond) (2020) 134 (7): 871–884.
Published: 14 April 2020
...) was inserted under the renal capsule into the cortex of each kidney to ensure renal interstitial (RI) infusion of vehicle D 5 W or pharmacological agent at 2.5 µl/min with a syringe pump (Harvard; model 55-222). When more than one agent was simultaneously infused, separate interstitial catheters were employed...
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Clin Sci (Lond) (2020) 134 (6): 641–656.
Published: 27 March 2020
... of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin–angiotensin–aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation...
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Clin Sci (Lond) (2020) 134 (1): 75–85.
Published: 17 January 2020
... was measured in human kidney biopsies with DN and in kidneys of db/db mice. The role of Renalase in the development of DN was examined using a genetically engineered mouse model: Renalase knockout mice with db/db background. The renoprotective effects of Renalase in DN was evaluated in db/db mice with Renalase...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (2): 167–180.
Published: 18 January 2019
...Mathilde L. Bonnemaison; Eileen S. Marks-Nelson; Erika I. Boesen Systemic lupus erythematosus (SLE) is an autoimmune disease predominantly affecting women and often leading to lupus nephritis and kidney damage. Endoplasmic reticulum (ER) stress has been implicated in several forms of kidney disease...
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Clin Sci (Lond) (2019) 133 (1): 41–54.
Published: 03 January 2019
..., an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine...
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Clin Sci (Lond) (2018) 132 (17): 1977–1994.
Published: 14 September 2018
...Meg L. McFetridge; Mark P. Del Borgo; Marie-Isabel Aguilar; Sharon D. Ricardo Chronic kidney disease (CKD) is a major and growing public health concern with increasing incidence and prevalence worldwide. The therapeutic potential of stem cell therapy, including mesenchymal stem cells (MSCs...
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Clin Sci (Lond) (2016) 130 (15): 1307–1326.
Published: 29 June 2016
... mechanism against AT1R-mediated actions. Thus, this review will focus on providing insights into the biological role of the AT2R, in particular its actions within the renal and cardiovascular system. AT2 receptor AT2R agonism cardiovascular compound 21 kidney To date, it still remains unclear...
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Clin Sci (Lond) (2014) 127 (7): 423–433.
Published: 17 June 2014
.... Correspondence: Professor Carol A. Pollock (email carol.pollock@sydney.edu.au ). 29 1 2014 24 3 2014 16 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 diabetic nephropathy calcium-activated potassium channel inflammatory cell K Ca 3.1 kidney renal...
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Clin Sci (Lond) (2014) 127 (1): 15–17.
Published: 10 March 2014
... in the cardiovascular and renal system, its involvement in hypertensive organ dysfunctions, such as those that occur in kidney, has not been investigated. In the present issue of Clinical Science , Alique and co-workers have demonstrated that angiotensin II-induced renal inflammatory responses were attenuated in mice...
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Clin Sci (Lond) (2014) 127 (1): 19–31.
Published: 10 March 2014
... blockers are renoprotective and down-regulate ILK in experimental kidney disease, but the involvement of ILK in the actions of AngII in the kidney has not been addressed. Therefore we have investigated whether ILK signalling modulates the kidney response to systemic AngII infusion in wild-type and ILK...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (10): 685–694.
Published: 27 January 2014
...Harshini Mudaliar; Carol Pollock; Usha Panchapakesan Diabetic nephropathy is the leading cause of kidney failure and its increasing prevalence and incidence has imposed global socio-economic stress on healthcare systems worldwide. Although historically considered a metabolic disorder, recent...
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Clin Sci (Lond) (2014) 126 (5): 315–328.
Published: 25 October 2013
... ( Nephs1 ) and Neph3 ( Kirrel2 ) genes, but the other Neph family members, Neph1 ( Kirrel ) and Neph2 ( Kirrel3 ), are expressed in the kidney precursors during chicken development. Despite the absence of nephrin and Neph3, chickens have a three-layered glomerular filtration barrier with SDs [ 30 , 31...
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Clin Sci (Lond) (2013) 124 (12): 701–710.
Published: 26 February 2013
... lines demonstrated similar elevations of BP (blood pressure) and plasma potassium after 4 weeks of TG induction. Withdrawal of doxycycline switched off mutant TG expression and the disappearance of the PHAII phenotype. Western blotting of microdissected kidney nephron segments confirmed that expression...
Includes: Supplementary data
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Clin Sci (Lond) (2013) 124 (6): 351–370.
Published: 27 November 2012
... by its action on a restricted number of tissues; however, it has now become clear that this hormone controls an array of cellular processes in many different tissues. The present review will focus on the role of insulin in the kidney in health and disease. Correspondence: Dr Richard Coward (email...
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Clin Sci (Lond) (2013) 124 (3): 191–202.
Published: 17 October 2012
... species) have been implicated in the development of diabetic nephropathy. Of the Nox isoforms in the kidney, Nox4 is important because of its renal abundance. In the present study, we tested the hypothesis that GKT136901, a Nox1/4 inhibitor, prevents the development of nephropathy in db / db (diabetic...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (6): 333–346.
Published: 29 May 2012
...Danielle Zimmerman; Kevin D. Burns Ang-(1–7) [angiotensin-(1–7)] is a biologically active heptapeptide component of the RAS (renin–angiotensin system), and is generated in the kidney at relatively high levels, via enzymatic pathways that include ACE2 (angiotensin-converting enzyme 2...
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Clin Sci (Lond) (2012) 123 (1): 1–14.
Published: 12 March 2012
...Anke L. Lameris; Leo A. Monnens; René J. Bindels; Joost G. J. Hoenderop Magnesium (Mg 2+ ) balance is tightly regulated by the concerted actions of the intestine, bone and kidneys. This balance can be disturbed by a broad variety of drugs. Diuretics, modulators of the EGFR (epidermal growth factor...
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Clin Sci (Lond) (2012) 122 (10): 439–447.
Published: 20 January 2012
... microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges...
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Clin Sci (Lond) (2012) 122 (6): 281–288.
Published: 11 November 2011
... developmental programming extracellular fluid hyperphagia kidney salt appetite Prenatal exposure to an adverse environment has a marked impact upon the developing kidney. People whose birthweights were towards the lower end of the normal range have fewer nephrons [ 1 ] and are at greater risk...
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Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
...Elena Velkoska; Rachael G. Dean; Luke Burchill; Vicki Levidiotis; Louise M. Burrell Alterations within the RAS (renin–angiotensin system) are pivotal for the development of renal disease. ACE2 (angiotensin-converting enzyme 2) is expressed in the kidney and converts the vasoconstrictor AngII...
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Clin Sci (Lond) (2010) 118 (1): 71–77.
Published: 02 October 2009
...Paul R. Kalra; Jonathan R. Clague; Andrew J. Coats; Stefan D. Anker; Philip A. Poole-Wilson; Allan D. Struthers CNP (C-type natriuretic peptide) is a vasodilatory peptide produced by vascular endothelium and the human heart with a short half-life. CNP has been identified within the human kidney...
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Clin Sci (Lond) (2010) 118 (1): 1–18.
Published: 28 September 2009
...Henrik Dimke; Joost G. Hoenderop; René J. Bindels The kidney plays an important role in maintaining the systemic Ca 2+ and Mg 2+ balance. Thus the renal reabsorptive capacity of these cations can be amended to adapt to disturbances in plasma Ca 2+ and Mg 2+ concentrations. The reabsorption of Ca 2...
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Clin Sci (Lond) (2009) 117 (2): 75–84.
Published: 15 June 2009
... + . Western blotting and quantitative PCR showed that NKCC2 expression was increased, whereas NCC mRNA was not up-regulated. Na + /K + ATPase α 1 subunit expression did not differ from controls; however, there was a significant reduction in whole kidney pump activity (23.4±1.8 and 17.7±1.2 nmol...
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Clin Sci (Lond) (2008) 114 (9): 589–590.
Published: 02 April 2008
... antagonist [Des-His 1 -Glu 9 ]glucagon. Thus the results document a sustained glycaemic effect of hyperglucagonaemia. Interestingly, probably because of the resulting hyperglycaemia, the glucagon-infused animals had features of diabetic nephropathy: increased kidney weight/body weight ratios, albuminuria...
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Clin Sci (Lond) (2008) 114 (9): 591–601.
Published: 02 April 2008
... increased serum glucagon by 129% ( P <0.05), raised systolic BP (blood pressure) by 21 mmHg ( P <0.01), elevated fasting blood glucose by 42% ( P <0.01), impaired glucose tolerance ( P <0.01), increased the kidney weight/body weight ratio ( P <0.05) and 24 h urinary albumin excretion by 108...
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Clin Sci (Lond) (2007) 113 (7): 297–311.
Published: 03 September 2007
... of the literature since Y2K (year 2000) is provided, with a general overview of PGs and their synthesis enzymes, and then specific considerations of each PG/prostanoid receptor system in the kidney. © The Authors Journal compilation © 2007 Biochemical Society 2007 More recent studies have also revealed...
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Clin Sci (Lond) (2007) 112 (12): 583–597.
Published: 14 May 2007
... Society 2007 artery blood pressure central nervous system dopamine receptor hypertension kidney sodium homoeostasis Essential hypertension affects 25% of the adult population and constitutes a major risk factor for stroke, myocardial infarction, heart failure and kidney failure [ 1 – 3...
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Clin Sci (Lond) (2007) 112 (6): 337–344.
Published: 12 February 2007
... 08.00 to 20.00 hours. arterial hypotension blood pressure circadian variation kidney normal pressure glaucoma orthostatic test sodium handling For several decades, COAG (chronic open angle glaucoma) has been considered as a disease essentially due to an increased IOP (intra-ocular...
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Clin Sci (Lond) (2006) 111 (1): 21–34.
Published: 14 June 2006
...-derived metabolite in the kidney and acts on EP receptors (PGE 2 receptors) to influence renal vascular resistance [ 6 , 7 ]. Although PGE 2 has been demonstrated to increase renal blood flow and GFR, EP 1 and EP 3 receptor activation can result in constriction of the renal vasculature [ 2 , 6 – 10...
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Clin Sci (Lond) (2006) 111 (1): 61–70.
Published: 14 June 2006
... protein von Hippel–Lindau, which leads to constitutively elevated HIF-1. We hypothesized that AM is increased in CC-RCC tumours and that AM is a plasma biomarker for CC-RCC. Tumours and non-malignant kidney tissue were obtained from patients that underwent unilateral nephrectomy. Blood samples were drawn...
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Clin Sci (Lond) (2004) 107 (2): 159–165.
Published: 27 July 2004
... from a variety of sources and undergoes partial absorption from the intestine [ 1 ]. Prevention of harmful aluminium accumulation in the body relies on aluminium excretion by the kidneys. However, only limited information is available concerning the nature of renal aluminium handling, partly because...