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Keywords: Klotho
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Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... this protection. The first pathway is through promoting pathways of cell metabolism, which they speculate helps the remaining functional nephrons adapt to the greater metabolic needs required to maintain kidney filtration. The second pathway is by restoration of α-Klotho levels, which may limit the expression...
Clin Sci (Lond) (2021) 135 (15): 1915–1927.
Published: 10 August 2021
...Makoto Kuro-o The klotho gene, named after a Greek goddess who spins the thread of life, was identified as a putative ‘ageing-suppressor’ gene. Klotho-deficient mice exhibit complex ageing-like phenotypes including hypogonadism, arteriosclerosis (vascular calcification), cardiac hypertrophy...
Clin Sci (Lond) (2020) 134 (1): 15–32.
Published: 03 January 2020
... to maintain phosphaturia and normal serum phosphorus values. Renal Klotho expression was preserved in Nx rats on a 0.2% phosphorus diet, reduced on a 0.4% phosphorus diet, and markedly reduced in Nx rats receiving LPS. In ex vivo experiments, high phosphorus and LPS increased nuclear β-catenin and p65-NFκB...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (7): 399–416.
Published: 07 June 2012
... in arterial wall composition are also observed. Activation of the RAS (renin–angiotensin system), ET-1 (endothelin-1), endothelial dysfunction, oxidative stress and ADMA (asymmetric ω- N G , N G -dimethylarginine), as well as the anti-aging molecule Klotho, are implicated in this process. The present review...
Clin Sci (Lond) (2011) 120 (3): 91–97.
Published: 14 October 2010
... of the FGF23–klotho system can lead to hyperphosphataemia with extensive tissue damage caused by phosphate toxicity. The cause and consequences of phosphate toxicity will be briefly summarized in the present review. Figure 2 Partial list of pathological events related to phosphate toxicity as documented...