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1-6 of 6
Keywords: Klotho
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (20): 1433–1437.
Published: 18 October 2022
... this protection. The first pathway is through promoting pathways of cell metabolism, which they speculate helps the remaining functional nephrons adapt to the greater metabolic needs required to maintain kidney filtration. The second pathway is by restoration of α-Klotho levels, which may limit the expression...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1915–1927.
Published: 10 August 2021
...Makoto Kuro-o The klotho gene, named after a Greek goddess who spins the thread of life, was identified as a putative ‘ageing-suppressor’ gene. Klotho-deficient mice exhibit complex ageing-like phenotypes including hypogonadism, arteriosclerosis (vascular calcification), cardiac hypertrophy...
Articles
Maria E. Rodríguez-Ortiz, Juan M. Díaz-Tocados, Juan R. Muñoz-Castañeda, Carmen Herencia, Carmen Pineda, Julio M. Martínez-Moreno, Addy Montes de Oca, Rodrigo López-Baltanás, Juan Alcalá-Díaz, Alberto Ortiz, Escolástico Aguilera-Tejero, Arnold Felsenfeld, Mariano Rodríguez, Yolanda Almadén
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 15–32.
Published: 03 January 2020
... to maintain phosphaturia and normal serum phosphorus values. Renal Klotho expression was preserved in Nx rats on a 0.2% phosphorus diet, reduced on a 0.4% phosphorus diet, and markedly reduced in Nx rats receiving LPS. In ex vivo experiments, high phosphorus and LPS increased nuclear β-catenin and p65-NFκB...
Includes: Supplementary data
Articles
Ernesto Martín-Núñez, Javier Donate-Correa, Ángel López-Castillo, Alejandro Delgado-Molinos, Carla Ferri, Sergio Rodríguez-Ramos, Purificación Cerro, Nayra Pérez-Delgado, Victoria Castro, Carolina Hernández-Carballo, Carmen Mora-Fernández, Juan F. Navarro-González
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (21): 2601–2609.
Published: 25 October 2017
... inflammatory disorder affecting the artery wall. Klotho, an anti-aging factor expressed in the vessel walls that participates in the maintenance of vascular homeostasis, can be down-regulated by inflammation. In this proof-of-concept work we seek to characterize the arterial KLOTHO expression in the vascular...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 399–416.
Published: 07 June 2012
... in arterial wall composition are also observed. Activation of the RAS (renin–angiotensin system), ET-1 (endothelin-1), endothelial dysfunction, oxidative stress and ADMA (asymmetric ω- N G , N G -dimethylarginine), as well as the anti-aging molecule Klotho, are implicated in this process. The present review...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (3): 91–97.
Published: 14 October 2010
... of the FGF23–klotho system can lead to hyperphosphataemia with extensive tissue damage caused by phosphate toxicity. The cause and consequences of phosphate toxicity will be briefly summarized in the present review. Correspondence: Dr M. Shawkat Razzaque (email [email protected] or debpur...