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Keywords: LAT1
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Articles

Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling

In Collection
Reproductive Physiology and Disease
Fredrick J. Rosario, Johann Urschitz, Theresa L. Powell, Thomas L. Brown, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1651–1664.
https://doi.org/10.1042/CS20230490
Published: 10 November 2023
...Fredrick J. Rosario; Johann Urschitz; Theresa L. Powell; Thomas L. Brown; Thomas Jansson The System L amino acid transporter, particularly the isoform Large Neutral Amino Acid Transporter Small Subunit 1 (LAT1) encoded by SLC7A5 , is believed to mediate the transfer of essential amino acids...
View articletitled, Overexpression of the LAT1 in primary human trophoblast cells increases the uptake of essential amino acids and activates mTOR signaling
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Articles

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

Fredrick J. Rosario, Kris Genelyn Dimasuay, Yoshikatsu Kanai, Theresa L. Powell, Thomas Jansson
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (7): 499–512.
https://doi.org/10.1042/CS20150554
Published: 17 February 2016
... increases transporter ubiquitination resulting in decreased transporter expression in the plasma membrane. mTORC 1 inhibition increased the expression of Nedd4-2, promoted ubiquitination and decreased the plasma membrane expression of SNAT2 (an isoform of the System A amino acid transporter) and LAT1...
View articletitled, Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2
Open the PDF for Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2 in another window
Includes: Supplementary data