...William S. Powell Eicosanoids comprise a group of oxidation products of arachidonic and 5,8,11,14,17-eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major pathways for eicosanoid formation are initiated by the actions of 5-lipoxygenase (5-LO), leading to leukotrienes...

... interleukin-6 Kupffer cells leukotrienes prostaglandins tumour necrosis factor Clinical Science (1995) 88, 21 1-217 (Printed in Great Britain) 21 I Production of eicosanoids and cytokines by Kupffer cells from young and old rats stimulated by endotoxin A. BROUWER, S. G. PARKER*, H. F. J. HENDRIKS, L...

... ml/min, and was recovered 30 cm distally by siphonage. Effluents were assayed for tumour necrosis factor by a specific e.l.i.s.a. and for prostaglandin E 2 and leukotriene B 4 by specific r.i.a.s. 3. The intracolonic release of tumour necrosis factor was undetectable in patients with irritable bowel...

...Jonathan P. Arm; Tak H. Lee Clinical Science (1993) 84, 501-510 (Printed in Great Britain) Editorial Review Sulphidopeptide leukotrienes in asthma Jonathan P. ARM and Tak H. LEE National Asthma Campaign Department of Allergy and Allied Respiratory Disorders, UMDS, Guy s Hospital, London, U.K...

...Adrian J. B. Brady; Frances M. Williams; Timothy J. Williams © 1992 The Biochemical Society and the Medical Research Society 1992 adenosine adhesion molecules complement endothelium inflammation leukotrienes myocardial ischaemia neutrophils oxygen free radicals reperfusion injury...

... of 0.1. This sequence of alternated F 1 o 2 0.4 and F 1 o 2 0.1 was repeated (1) in the dogs with a strong pulmonary pressor response to hypoxia (more than 20% increase in pulmonary vascular resistance) ( n = 6) under a continuous infusion of the leukotriene receptor blocker FPL 57231 (2 mg min −1 kg −1...

...A. G. Leitch; K. F. Austen; E. J. Corey; J. M. Drazen 1. We measured pulmonary conductance ( G L ), dynamic compliance ( C dyn .), and arterial pressure in chloralose-urethane anaesthetized guinea pigs for 30 min after intravenous infusion of either leukotriene (LT) C 4 (1 μg/kg) or LTD 4 (0.5 μg...