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Keywords: Mas receptor
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Articles
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
...) and to elucidate the potential cross-talk among AT 2 R, Mas receptor (MasR) and/or bradykinin type 2 receptor (B 2 R) in this response. Five-week-old male C57BL6J mice were fed a standard (CHOW) or a high-fat diet (HF) for 6 weeks and treated daily with C21 (1 mg/kg p.o) or vehicle, generating four groups: CHOW-C...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... by MLN4760, a potent ACE2 inhibitor, or if the Mas receptor (MasR) was blocked by A779, a MasR antagonist. Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing Ang 1-7 and activating the MasR while blocking...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
...-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions...
Articles
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(1–7)], through its Mas receptor, has...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (4): 227–234.
Published: 17 October 2014
...@health.sdu.dk ). 2 9 2013 30 7 2014 13 8 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 angiotensin type 2 receptor (AT 2 R) Mas receptor renin–angiotensin system (RAS) The renin–angiotensin system (RAS) is usually associated with cardiovascular...
Articles
Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(1–7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
Articles
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... pathway. We also address the molecular mechanisms behind the beneficial effects of Ang-(1–7) on AngII-mediated insulin resistance. Finally, we discuss potential therapeutic approaches leading to modulation of the ACE2 (angiotensin-converting enzyme 2)/Ang-(1–7)/Mas receptor axis as a very attractive...
Articles
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
.... Ang-(1–7) has been shown to inhibit the NF-κB pathway in rats with permanent MCAO [ 93 ]. The authors also confirmed a reduction in TNF-α, IL-1β and COX-2 (cyclo-oxygenase 2) in the peri-infarct regions. The effects of Ang-(1–7) were reversed by the Mas receptor antagonist A-779, and A-779 alone...
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Clin Sci (Lond) (2013) 125 (2): 57–65.
Published: 26 March 2013
... associated with phospholipase C activation [ 50 ], has been shown to specifically bind Ang-(1–7) and is involved in many of its biological actions [ 8 , 51 ]. At the central level, a strong staining for the Mas receptor was found in the NTS, CVLM and RVLM, inferior olive, parvocellular and magnocellular...
Articles
Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
... Ang-(1–7) signalling, it has been reported that Ang-(1–7) phosphorylates the insulin downstream effectors PI3K (phosphoinositide 3-kinase) and AKT via the Mas receptor in HAECs [ 38 , 39 ], and IRS1 (insulin receptor substrate 1) and JAK2 (Janus kinase 2) via the AT 1 R in rat hearts [ 39 ]. Moreover...
Articles
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
... in the present review. Dedicated studies have now provided clear evidence that ACE, AngII/AT 1 receptor and Ang-(1–7)/Mas receptor activity are involved in haematopoiesis, as well as in the formation of cardiovascular cells and other somatic cell types from progenitor cells [ 27 ]. In the present article...
Articles
Clin Sci (Lond) (2010) 119 (9): 385–394.
Published: 23 July 2010
... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...
Articles
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
... induced by STNx (subtotal nephrectomy). STNx and Control rats received vehicle or ramipril (1 mg·kg −1 of body weight·day −1 ), and renal ACE, ACE2 and mas receptor gene and protein expression were measured 10 days later. STNx rats were characterized by polyuria, proteinuria, hypertension and elevated...