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Keywords: Mas receptor
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Articles
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
...) and to elucidate the potential cross-talk among AT 2 R, Mas receptor (MasR) and/or bradykinin type 2 receptor (B 2 R) in this response. Five-week-old male C57BL6J mice were fed a standard (CHOW) or a high-fat diet (HF) for 6 weeks and treated daily with C21 (1 mg/kg p.o) or vehicle, generating four groups: CHOW-C...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... by MLN4760, a potent ACE2 inhibitor, or if the Mas receptor (MasR) was blocked by A779, a MasR antagonist. Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing Ang 1-7 and activating the MasR while blocking...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
...-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions...
Articles
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(1–7)], through its Mas receptor, has...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 128 (4): 227–234.
Published: 17 October 2014
... interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning. angiotensin type 2 receptor (AT 2 R) Mas receptor renin–angiotensin system (RAS) The renin...
Articles
Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(1–7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
Articles
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... pathway. We also address the molecular mechanisms behind the beneficial effects of Ang-(1–7) on AngII-mediated insulin resistance. Finally, we discuss potential therapeutic approaches leading to modulation of the ACE2 (angiotensin-converting enzyme 2)/Ang-(1–7)/Mas receptor axis as a very attractive...
Articles
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
... the cerebrovasculature and thus maintain improved cerebral blood flow. Correspondence: Dr Colin Sumners (email [email protected] ). 26 6 2013 18 7 2013 13 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin inflammation Mas receptor renin renin...
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Clin Sci (Lond) (2013) 125 (2): 57–65.
Published: 26 March 2013
... of the baroreflex, enhancement of sympathetic outflow and augmented vasopressin release [ 1 – 3 ]. angiotensin-(1–7) hypertension Mas receptor noradrenaline (norepinephrine) synapse tyrosine hydroxylase The RAS (renin–angiotensin system) is one of the major systems in the regulation...
Articles
Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
...) treatment, which probably leads to MAPK1 inactivation [ 42 ]. angiotensin-(1–7) angiotensin-converting enayme 2 (ACE2) Mas receptor renin–angiotensin system (RAS) Figure 2 Main non-cardiovascular effects of Ang-(1–7) via Mas in different tissues and processes ( A ) Signalling molecules...
Articles
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
... is being explored for cardiovascular therapy with specific AT 2 receptor agonists [ 9 ]. angiotensin angiotensin II receptor bone marrow Mas receptor haematopoietic stem cell mesenchymal stem cell renin–angiotensin system The mechanism of AngII-mediated regulation of erythropoesis...
Articles
Clin Sci (Lond) (2010) 119 (9): 385–394.
Published: 23 July 2010
... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...
Articles
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
... induced by STNx (subtotal nephrectomy). STNx and Control rats received vehicle or ramipril (1 mg·kg −1 of body weight·day −1 ), and renal ACE, ACE2 and mas receptor gene and protein expression were measured 10 days later. STNx rats were characterized by polyuria, proteinuria, hypertension and elevated...