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1-16 of 16
Keywords: Mas receptor
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Articles
Raquel González-Blázquez, Martín Alcalá, María S. Fernández-Alfonso, Ulrike Muscha Steckelings, M. Paz Lorenzo, Marta Viana, William A. Boisvert, Thomas Unger, Marta Gil-Ortega, Beatriz Somoza
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
...) and to elucidate the potential cross-talk among AT 2 R, Mas receptor (MasR) and/or bradykinin type 2 receptor (B 2 R) in this response. Five-week-old male C57BL6J mice were fed a standard (CHOW) or a high-fat diet (HF) for 6 weeks and treated daily with C21 (1 mg/kg p.o) or vehicle, generating four groups: CHOW-C...
Includes: Supplementary data
Articles
Reda Hmazzou, Yannick Marc, Adrien Flahault, Romain Gerbier, Nadia De Mota, Catherine Llorens-Cortes
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... by MLN4760, a potent ACE2 inhibitor, or if the Mas receptor (MasR) was blocked by A779, a MasR antagonist. Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing Ang 1-7 and activating the MasR while blocking...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2929–2941.
Published: 16 November 2020
... of the ACE2/Ang-(1-7)/Mas receptor axis in female and male reproduction, from gametogenesis to pregnancy and postpartum. Correspondence: Adelina M. Reis ( [email protected] ) or Fernando M. Reis ( [email protected] ) 11 09 2020 13 10 2020 30 10 2020 © 2020 The Author(s...
Articles
Satoko Nozato, Koichi Yamamoto, Hikari Takeshita, Yoichi Nozato, Yuki Imaizumi, Taku Fujimoto, Serina Yokoyama, Motonori Nagasawa, Masao Takeda, Kazuhiro Hongyo, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masaki Mogi, Masatsugu Horiuchi, Hiromi Rakugi
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (18): 2005–2018.
Published: 24 September 2019
... of the Biochemical Society 2019 Angiotensin 1-7 Angiotensin Converting Enzyme 2 Mas receptor Muscle weakness osteoporosis Physiological aging is a long-term process that can result in diverse health conditions in older adults. This diversity creates a high-risk elderly population with health issues...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
...-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions...
Articles
María Gabriela Morales, Hugo Olguín, Gabriella Di Capua, Enrique Brandan, Felipe Simon, Claudio Cabello-Verrugio
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(1–7)], through its Mas receptor, has...
Includes: Supplementary data
Articles
Daniel Villela, Julia Leonhardt, Neal Patel, Jason Joseph, Sebastian Kirsch, Anders Hallberg, Thomas Unger, Michael Bader, Robson A. Santos, Colin Sumners, U. Muscha Steckelings
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (4): 227–234.
Published: 17 October 2014
... interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning. angiotensin type 2 receptor (AT 2 R) Mas receptor renin–angiotensin system (RAS) The renin...
Articles
Mariela M. Gironacci, Flavia M. Cerniello, Nadia A. Longo Carbajosa, Jorge Goldstein, Bruno D. Cerrato
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(1–7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... pathway. We also address the molecular mechanisms behind the beneficial effects of Ang-(1–7) on AngII-mediated insulin resistance. Finally, we discuss potential therapeutic approaches leading to modulation of the ACE2 (angiotensin-converting enzyme 2)/Ang-(1–7)/Mas receptor axis as a very attractive...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
... the cerebrovasculature and thus maintain improved cerebral blood flow. Correspondence: Dr Colin Sumners (email [email protected] ). 26 6 2013 18 7 2013 13 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiotensin inflammation Mas receptor renin renin...
Articles
Álvaro P. S. Souza, Deny B. S. Sobrinho, Jônathas F. Q. Almeida, Gisele M. M. Alves, Larissa M. Macedo, Juliana E. Porto, Eneida F. Vêncio, Diego B. Colugnati, Robson A. S. Santos, Anderson J. Ferreira, Elizabeth P. Mendes, Carlos H. Castro
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (9): 449–459.
Published: 08 July 2013
... the coronary effects of Ang-(1–7) [angiotensin-(1–7)] in hypertrophic rat hearts. Heart hypertrophy was induced by abdominal aorta CoA (coarctation). Ang-(1–7) and AVE 0991, a non-peptide Mas-receptor agonist, at picomolar concentration, induced a significant vasodilation in hearts from sham-operated rats...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (2): 57–65.
Published: 26 March 2013
... of the baroreflex, enhancement of sympathetic outflow and augmented vasopressin release [ 1 – 3 ]. angiotensin-(1–7) hypertension Mas receptor noradrenaline (norepinephrine) synapse tyrosine hydroxylase The RAS (renin–angiotensin system) is one of the major systems in the regulation...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
...) treatment, which probably leads to MAPK1 inactivation [ 42 ]. angiotensin-(1–7) angiotensin-converting enayme 2 (ACE2) Mas receptor renin–angiotensin system (RAS) Figure 2 Main non-cardiovascular effects of Ang-(1–7) via Mas in different tissues and processes ( A ) Signalling molecules...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
... is being explored for cardiovascular therapy with specific AT 2 receptor agonists [ 9 ]. angiotensin angiotensin II receptor bone marrow Mas receptor haematopoietic stem cell mesenchymal stem cell renin–angiotensin system The mechanism of AngII-mediated regulation of erythropoesis...
Articles
Kátia D. da Silveira, Kênia S. Pompermayer Bosco, Lúcio R. L. Diniz, Adriana K. Carmona, Giovanni D. Cassali, Oscar Bruna-Romero, Lirlândia P. de Sousa, Mauro M. Teixeira, Robson A. S. Santos, Ana C. Simões e Silva, Maria A. Ribeiro Vieira
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (9): 385–394.
Published: 23 July 2010
... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
... induced by STNx (subtotal nephrectomy). STNx and Control rats received vehicle or ramipril (1 mg·kg −1 of body weight·day −1 ), and renal ACE, ACE2 and mas receptor gene and protein expression were measured 10 days later. STNx rats were characterized by polyuria, proteinuria, hypertension and elevated...