1-16 of 16
Keywords: Mas receptor
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Clin Sci (Lond) (2021) 135 (9): 1145–1163.
Published: 11 May 2021
...) and to elucidate the potential cross-talk among AT 2 R, Mas receptor (MasR) and/or bradykinin type 2 receptor (B 2 R) in this response. Five-week-old male C57BL6J mice were fed a standard (CHOW) or a high-fat diet (HF) for 6 weeks and treated daily with C21 (1 mg/kg p.o) or vehicle, generating four groups: CHOW-C...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (6): 775–791.
Published: 17 March 2021
... by MLN4760, a potent ACE2 inhibitor, or if the Mas receptor (MasR) was blocked by A779, a MasR antagonist. Our findings suggest that in the brain, the increase in ACE2 activity resulting from APA inhibition by RB150/firibastat treatment, subsequently increasing Ang 1-7 and activating the MasR while blocking...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
...-converting enzyme/AT1 receptors, and the depressor and protective one, represented by Ang-(1–7)/ angiotensin-converting enzyme 2/Mas receptors. Although the RAS exerts a pivotal role on electrolyte homeostasis and blood pressure regulation, their components are also implicated in higher brain functions...
Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
... and muscle mass, an increase in MHC (myosin heavy chain) degradation, and an increase in the expression of atrogin-1 and MuRF-1 (muscle-specific RING-finger protein 1), two ubiquitin E3 ligases belonging to the ubiquitin–proteasome system. Ang-(1–7) [Angiotensin-(1–7)], through its Mas receptor, has...
Includes: Supplementary data
Clin Sci (Lond) (2015) 128 (4): 227–234.
Published: 17 October 2014
...@health.sdu.dk ). 2 9 2013 30 7 2014 13 8 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 angiotensin type 2 receptor (AT 2 R) Mas receptor renin–angiotensin system (RAS) The renin–angiotensin system (RAS) is usually associated with cardiovascular...
Clin Sci (Lond) (2014) 127 (5): 295–306.
Published: 07 May 2014
...), and the depressor arm represented by Ang-(1–7) [angiotensin-(1–7)]/ACE2/Mas receptors. All of the components of the RAS are present in the brain. Within the brain, Ang-(1–7) contributes to the regulation of BP (blood pressure) by acting at regions that control cardiovascular function such that, when Ang-(1–7...
Clin Sci (Lond) (2014) 126 (9): 613–630.
Published: 14 January 2014
... pathway. We also address the molecular mechanisms behind the beneficial effects of Ang-(1–7) on AngII-mediated insulin resistance. Finally, we discuss potential therapeutic approaches leading to modulation of the ACE2 (angiotensin-converting enzyme 2)/Ang-(1–7)/Mas receptor axis as a very attractive...
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
.... Ang-(1–7) has been shown to inhibit the NF-κB pathway in rats with permanent MCAO [ 93 ]. The authors also confirmed a reduction in TNF-α, IL-1β and COX-2 (cyclo-oxygenase 2) in the peri-infarct regions. The effects of Ang-(1–7) were reversed by the Mas receptor antagonist A-779, and A-779 alone...
Clin Sci (Lond) (2013) 125 (2): 57–65.
Published: 26 March 2013
... associated with phospholipase C activation [ 50 ], has been shown to specifically bind Ang-(1–7) and is involved in many of its biological actions [ 8 , 51 ]. At the central level, a strong staining for the Mas receptor was found in the NTS, CVLM and RVLM, inferior olive, parvocellular and magnocellular...
Clin Sci (Lond) (2013) 124 (7): 443–456.
Published: 07 December 2012
... Ang-(1–7) signalling, it has been reported that Ang-(1–7) phosphorylates the insulin downstream effectors PI3K (phosphoinositide 3-kinase) and AKT via the Mas receptor in HAECs [ 38 , 39 ], and IRS1 (insulin receptor substrate 1) and JAK2 (Janus kinase 2) via the AT 1 R in rat hearts [ 39 ]. Moreover...
Clin Sci (Lond) (2012) 123 (4): 205–223.
Published: 24 April 2012
... in the present review. Dedicated studies have now provided clear evidence that ACE, AngII/AT 1 receptor and Ang-(1–7)/Mas receptor activity are involved in haematopoiesis, as well as in the formation of cardiovascular cells and other somatic cell types from progenitor cells [ 27 ]. In the present article...
Clin Sci (Lond) (2010) 119 (9): 385–394.
Published: 23 July 2010
... enzyme) and the AT 1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1–7) [angiotensin-(1–7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor...
Clin Sci (Lond) (2010) 118 (4): 269–279.
Published: 16 November 2009
... induced by STNx (subtotal nephrectomy). STNx and Control rats received vehicle or ramipril (1 mg·kg −1 of body weight·day −1 ), and renal ACE, ACE2 and mas receptor gene and protein expression were measured 10 days later. STNx rats were characterized by polyuria, proteinuria, hypertension and elevated...