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Keywords: Metabolism
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Articles
Wang-Hsin Lee, Zachary A. Kipp, Sally N. Pauss, Genesee J. Martinez, Evelyn A. Bates, Olufunto O. Badmus, David E. Stec, Terry D. Hinds, Jr
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (02): 171–198.
Published: 28 January 2025
...Wang-Hsin Lee; Zachary A. Kipp; Sally N. Pauss; Genesee J. Martinez; Evelyn A. Bates; Olufunto O. Badmus; David E. Stec; Terry D. Hinds, Jr Metabolic and insulin-resistant diseases, such as type 2 diabetes mellitus (T2DM), have become major health issues worldwide. The prevalence of insulin...
Articles
Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning
Open AccessLimin Shi, Jinying Yang, Zhipeng Tao, Louise Zheng, Tyler F. Bui, Ramon L. Alonso, Feng Yue, Zhiyong Cheng
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (6): 371–385.
Published: 12 March 2024
...Limin Shi; Jinying Yang; Zhipeng Tao; Louise Zheng; Tyler F. Bui; Ramon L. Alonso; Feng Yue; Zhiyong Cheng Browning of white adipose tissue is hallmarked by increased mitochondrial density and metabolic improvements. However, it remains largely unknown how mitochondrial turnover and quality control...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (6): 415–434.
Published: 21 March 2023
...Zhipeng Tao; Zhiyong Cheng Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated evidence has revealed a great deal of insulin and estrogen signaling pathways and their interplays in the regulation of mitochondrial, cellular remodeling, and macronutrient metabolism...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 639–642.
Published: 27 April 2022
... Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . 25-hydroxyvitamin D adipose bile cholecalciferol metabolism This year is the 100th anniversary of the first use of the term vitamin D to describe a fat-soluble...
Articles
Alkali therapy protects renal function, suppresses inflammation, and improves cellular metabolism in kidney disease
Available to PurchaseEva Maria Pastor Arroyo, Nima Yassini, Elif Sakiri, Giancarlo Russo, Soline Bourgeois, Nilufar Mohebbi, Kerstin Amann, Nicole Joller, Carsten A. Wagner, Pedro Henrique Imenez Silva
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 557–577.
Published: 21 April 2022
... is a major clinical challenge. Metabolic acidosis is both a consequence and a possible driver of CKD progression. Alkali therapy counteracts these effects in CKD patients, but underlying mechanisms remain incompletely understood. Here we show that bicarbonate supplementation protected renal function...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (11): 1389–1408.
Published: 04 June 2021
...Diana Cardoso; Esperanza Perucha The immune system protects the body against harm by inducing inflammation. During the immune response, cells of the immune system get activated, divided and differentiated in order to eliminate the danger signal. This process relies on the metabolic reprogramming...
Articles
Inhibition of ROCK2 alleviates renal fibrosis and the metabolic disorders in the proximal tubular epithelial cells
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1357–1376.
Published: 18 June 2020
... proximal tubular epithelial cells (mPTCs). Moreover, impaired cellular metabolism was reported as a crucial pathogenic factor in CKD. By metabolomics analysis, we found that KD025 restored the metabolic disturbance, including the impaired glutathione metabolism in TGF-β1-stimulated tubular epithelial cells...
Articles
Processes exacerbating apoptosis in non-alcoholic steatohepatitis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2245–2264.
Published: 19 November 2019
.... We focus on processes triggering and exacerbating apoptotic signalling in the liver of NAFLD patients and their metabolic and pathological implications. Indeed, liver injury and inflammation are cardinal histopathological features of NASH, a duo in which derailment of apoptosis is of paramount...
Articles
Adipocyte dedifferentiation in health and diseases
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Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2107–2119.
Published: 25 October 2019
...Tongxing Song; Shihuan Kuang Adipose tissues collectively as an endocrine organ and energy storage are crucial for systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or fat cells, are remarkably plastic and can increase or decrease their size and number...
Articles
NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy
Available to PurchaseXue-liang Zhou, Zhi-bo Liu, Rong-rong Zhu, Huang Huang, Qi-rong Xu, Hua Xu, Liang Zeng, Yun-yun Li, Cha-hua Huang, Qi-cai Wu, Ji-chun Liu
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (9): 1085–1096.
Published: 09 May 2019
...Xue-liang Zhou; Zhi-bo Liu; Rong-rong Zhu; Huang Huang; Qi-rong Xu; Hua Xu; Liang Zeng; Yun-yun Li; Cha-hua Huang; Qi-cai Wu; Ji-chun Liu Nuclear receptor binding SET domain 2 (NSD2)-mediated metabolic reprogramming has been demonstrated to regulate oncogenesis via catalyzing the methylation...
Articles
MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S -adenosylmethionine and de novo purine synthesis
Available to PurchaseYi-Cheng Wang, Ming-Tsung Wu, Feng-Yao Tang, Der-Yuan Chen, Hsin-An Ko, Barry Shane, Wen-Nan Huang, En-Pei Isabel Chiang
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 253–267.
Published: 25 January 2019
...Yi-Cheng Wang; Ming-Tsung Wu; Feng-Yao Tang; Der-Yuan Chen; Hsin-An Ko; Barry Shane; Wen-Nan Huang; En-Pei Isabel Chiang Objective: Currently, no guidelines are established for pharmacogenomic testing involving folate metabolic genes in long-term disease-modifying antirheumatic drugs’ (DMARD...
Articles
MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets
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Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (1): 23–40.
Published: 03 January 2019
...Silvia Lorente-Cebrián; Pedro González-Muniesa; Fermín I. Milagro; J. Alfredo Martínez Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2 diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation and related to white adipose tissue...
Articles
The ‘Goldilocks zone’ of fatty acid metabolism; to ensure that the relationship with cardiac function is just right
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Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2079–2094.
Published: 24 July 2017
... but less oxygen efficient fuel compared with glucose. The pathways involved in myocardial FA metabolism are regulated at various subcellular levels, and can be divided into sarcolemmal FA uptake, cytosolic activation and storage, mitochondrial uptake and β-oxidation. An understanding of the critical...
Articles
Lamins and metabolism
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Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (2): 105–111.
Published: 14 December 2016
... are autosomal dominant and can be roughly divided into four major groups: muscle diseases, peripheral neuronal diseases, accelerated aging disorders and metabolic diseases including Dunnigan type familial partial lipodystrophy (FLPD), acquired partial lipodystrophy (APL) and autosomal dominant leucodystrophy...
Articles
GPER–novel membrane oestrogen receptor
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Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (12): 1005–1016.
Published: 06 May 2016
... on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target. In 1997, a cDNA screen...
Articles
Impaired glucose tolerance after brief heat exposure: a randomized crossover study in healthy young men
Available to PurchaseCécile Faure, Keyne Charlot, Stéphane Henri, Marie-dominique Hardy-Dessources, Olivier Hue, Sophie Antoine-Jonville
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (12): 1017–1025.
Published: 06 May 2016
... of humans. The objective of this project was to examine the isolated and combined effects of experimental short-term mild heat exposure and metabolic level on glucoregulation. Two experimental randomized crossover studies were conducted. Ten healthy young men participated in study A, which comprises four...
Articles
Metabolic dysfunction in lymphocytes promotes postoperative morbidity
Available to PurchaseMark R. Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N. Karmali, S. Ramani Moonesinghe, Fares S. Haddad, Michael G. Mythen, Mervyn Singer, Gareth L. Ackland
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (5): 423–437.
Published: 11 June 2015
.... This hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying a potential...
Includes: Supplementary data
Articles
NUCKS: a potential biomarker in cancer and metabolic disease
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Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (10): 715–721.
Published: 10 March 2015
... and the metabolic syndrome, and how its sundry modifications can affect its function. Such studies could reveal how NUCKS could be a link between physiological cues and human ailments. 15 10 2014 1 12 2014 19 12 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 HMG...
Articles
Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability
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Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (1): 57–67.
Published: 29 August 2014
... study was to investigate the dose–response effect of intravenous arginine supplementation in post-absorptive patients with septic shock on arginine-NO and protein metabolism and on global and regional haemodynamics. Eight critically ill patients with a diagnosis of septic shock participated...
Includes: Supplementary data
Articles
Magnesium and its transporters in cancer: a novel paradigm in tumour development
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Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 417–427.
Published: 07 June 2012
... effects. In the present review, we briefly outline the new findings on the role of magnesium in angiogenesis and metastatization, and focus on the relationship between tumour cell proliferation and metabolic reprogramming, discussing how magnesium and its transporters are involved in these processes...
Articles
Cellular and molecular mechanisms of metformin: an overview
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Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
... status activates AMPK (AMP-activated protein kinase), a cellular metabolic sensor, providing a generally accepted mechanism for the action of metformin on hepatic gluconeogenesis. The demonstration that respiratory chain complex I, but not AMPK, is the primary target of metformin was recently...
Articles
Cellular and molecular effects of sirtuins in health and disease
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Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (5): 191–203.
Published: 20 May 2011
... as potential treatments. In the present review, we describe the functions of sirtuins in cell survival, inflammation, energy metabolism, cancer and differentiation, and their impact on diseases. We also discuss the organ-specific functions of sirtuins, focusing on the brain and blood vessels...
Articles
The circadian clock and metabolism
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Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (2): 65–72.
Published: 08 October 2010
... in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism. Animals with mutations in clock genes that disrupt cellular rhythmicity have provided evidence to the relationship between the circadian clock and metabolic homoeostasis. The present...
Articles
Presence of tumour inhibits the normal post-operative response in arginine and NO production in non-cachectic mice
Available to PurchaseYvonne L. J. Vissers, Maarten F. von Meyenfeldt, Yvette C. Luiking, Cornelis H. C. Dejong, Wim A. Buurman, Nicolaas E. P. Deutz
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (10): 527–532.
Published: 12 April 2007
... availability may be a specific feature of the presence of tumour. As arginine is important in post-operative repair, we hypothesized that abnormalities in arginine metabolism in cancer lead to an aberrant post-operative response in arginine and NO metabolism. To investigate this, we studied post-operative...
Articles
L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (5): 447–455.
Published: 24 October 2005
... changes in gene expression of BRIN-BD11 cells. Sixty-six genes were up-regulated >1.8-fold, including many involved in cellular signalling, metabolism, gene regulation, protein synthesis, apoptosis and the cellular stress response. Subsequent functional experiments confirmed that L -alanine provided...
Includes: Supplementary data
Articles
New insights into amino acid metabolism, β-cell function and diabetes
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Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (3): 185–194.
Published: 18 February 2005
... identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present review. Mitochondria generate ATP...
Articles
Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans
Available to PurchaseLuc J.C. van LOON, Audrey M. OOSTERLAAR, Fred HARTGENS, Matthijs K.C. HESSELINK, Rodney J. SNOW, Anton J.M. WAGENMAKERS
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (2): 153–162.
Published: 17 January 2003
...-mail [email protected] ). 18 6 2002 13 9 2002 14 11 2002 The Biochemical Society and the Medical Research Society © 2003 2003 creatine phosphate ergogenic aids functional foods metabolism oxidative capacity skeletal muscle substrate utilization 153Clinical Science...
Articles
Determinants of the acetate recovery factor: implications for estimation of [ 13 C]substrate oxidation
Available to PurchasePatrick SCHRAUWEN, Ellen E. BLAAK, Dorien P. C. van AGGEL-LEIJSSEN, Lars B. BORGHOUTS, Anton J. M. WAGENMAKERS
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (5): 587–592.
Published: 11 April 2000
...Patrick SCHRAUWEN; Ellen E. BLAAK; Dorien P. C. van AGGEL-LEIJSSEN; Lars B. BORGHOUTS; Anton J. M. WAGENMAKERS When using 13 C or 14 C tracers to study substrate metabolism, an acetate correction factor should be applied to correct for loss of label in the exchange pathways of the tricarboxylic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (3): 279–286.
Published: 01 March 1998
...D. Bendahan; M. Badier; Y. Jammes; S. Confort-Gouny; A. M. Salvan; C. Guillot; P. J. Cozzone 1. Failure of muscle force during sustained fatiguing contraction is associated with myoelectrical and metabolic alterations. However, the inter-relationships between these two types of events remain...
Articles
α-Adrenoceptor Mechanisms of Thermoregulation during Cold Challenge in Humans
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (5): 627–631.
Published: 01 November 1996
... vasoconstriction and metabolic heat production were measured. 3. The α-adrenoceptor antagonist caused a dose-dependent inhibition of vasoconstriction in the elderly but did not impair vasoconstriction in the young subjects at the doses that were given. Shivering and metabolic heat production were unaffected by α...
Articles
Effect of Methionine Loading on 5-Methyltetrahydrofolate, S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma of Healthy Humans
Available to PurchaseFranziska M. T. Loehrer, Walter E. Haefeli, Christian P. Angst, Garry Browne, Greta Frick, Brian Fowler
Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (1): 79–86.
Published: 01 July 1996
... to investigate impaired methionine metabolism, especially of the trans-sulphuration pathway, but most studies have focused on changes in homocysteine. 2. We investigated the effect of methionine excess on total plasma homocysteine, 5-methyltetrahydrofolate (which is the active form of folate in the remethylation...
Articles
Relationship between Serum Tryptophan and Tryptophan Metabolite Levels after Tryptophan Ingestion in Normal Subjects and Age-Related Cataract Patients
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (6): 591–599.
Published: 01 December 1995
... in tryptophan metabolism in the two groups. 3. Tryptophan, kynurenine, kynurenic acid, xanthurenic acid, 3-hydroxyanthranilic acid, 5-hydroxyanthranilic acid, 5-hydroxytryptophan and anthranilic acid were measured by HPLC with dual electrochemical and programmable wavelength fluorescence detection. Fasting...
Articles
Role of α-Adrenoceptors in the Maintenance of Core Temperature in Humans
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (3): 219–225.
Published: 01 September 1995
..., mean skin-surface temperature, fingertip capillary blood flow and metabolic heat production were measured. Dose—response curves were plotted for all measured variables, and males and females were compared to identify potential gender differences. 3. Core temperature decreased with all doses...
Articles
Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
... were reduced by 50% at day 4, no changes in intestinal amino acid and ammonia metabolism were observed. 3. In the liver, glutamine consumption was reduced and ammonia uptake was increased, but urea synthesis was not changed. The decreased intracellular glutamine, glutamate, aspartate and ammonia...
Articles
Tumour necrosis factor- α : Its role in the metabolic response to sepsis
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (3): 247–256.
Published: 01 March 1993
...Tom van der Poll; Hans P. Sauerwein © 1993 The Biochemical Society and the Medical Research Society 1993 cytokines endotoxin fat glucose metabolism sepsis stress hormones tumor necrosis factor-α Clinical Science (1993) 84, 247-256 (Printed in Great Britain) Editorial Review...
Articles
Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... rate. 20 7 1992 19 10 1992 © 1993 The Biochemical Society and the Medical Research Society 1993 amino acids constant infusion flooding dose fractional synthesis rate leucine metabolism modelling muscle protein degradation protein synthesis tracer Clinical Science...
Articles
Weight loss normalizes the inhibitory effect of N 6 -(phenylisopropyl)adenosine on lipolysis in fat cells of massively obese human subjects
Available to PurchaseJorma J. Ohisalo, Johanna M. Kaartinen, Susanna Ranta, Pertti Mustajoki, Stanely P. Hreniuk, Kathryn F. LaNoue, Louis F. Martin
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (5): 589–592.
Published: 01 November 1992
... observed in the inhibitory regulation of lipolysis in obesity are secondary. 26 5 1992 11 6 1992 © 1992 The Biochemical Society and the Medical Research Society 1992 adenosine adenylate cyclase cell size gastric bypass hormone regulation metabolism obesity Clinical Science...
Articles
Effects of lysine infusion on the renal metabolism of aprotinin (Trasylol) in man
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (3): 295–299.
Published: 01 September 1992
.... Lysine potently inhibits tubular peptide uptake, and may thus depress the uptake and metabolism of aprotinin. This was investigated in 14 glomerulonephritic patients with normal renal function and variable proteinuria and in one healthy subject. 2. 99m Tc-labelled aprotinin was given intravenously alone...
Articles
Hepatic glutamine metabolism in the septic rat
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (6): 709–716.
Published: 01 June 1992
...M. Salleh; M. Ardawi 1. The hepatic metabolism of glutamine, alanine, ammonia, urea, glutathione and glucose was studied in rats made septic by caecal ligation and puncture and was compared with that in rats that had undergone sham operation (laparotomy). 2. Sepsis resulted in increases...
Articles
Effects of epidermal growth factor and glutamine-supplemented parenteral nutrition on the small bowel of septic rats
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (5): 573–580.
Published: 01 May 1992
.... It is concluded that the administration of glutamine- supplemented parenteral nutrition, with or without epi- dermal growth factor, is beneficial to the small bowel of septic rats. INTRODUCTION The gastrointestinal tract is the most metabolically active cell mass in the entire body, regenerating its entire...
Articles
Metabolic balance studies of mineral supplementation in osteoporosis
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (6): 799–802.
Published: 01 December 1991
...-802 799 Metabolic balance studies of mineral supplementation in osteoporosis TREVOR STAMP, MONICA KATAKITY, A. J. GOLDSTEIN, M. V. JENKINS, C. R. KELSEY AND G. A. ROSE Department of Bone and Mineral Metabolism, Royal National Orthopaedic Hospital and Institute of Orthopaedics, Stanmore, Middlesex, U.K...
Articles
Reduced oxygen consumption induced by vasopressin in dogs depends on systemic administration
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (6): 751–758.
Published: 01 December 1991
...-' while the animals were breathing 10% oxygen. Hypoxaemia alone (arterial partial Key words: antidiuretic hormone, cardiac output, hypoxia, metabolism, oxygen consumption, regional blood flows. pressure of oxygen 4.67 kPa) decreased whole-body oxygen delivery by 30%. The fall in whole-body oxygen...
Articles
Glutamine and alanine metabolism in lungs of septic rats
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (5): 603–609.
Published: 01 November 1991
...M. Salleh M. Ardawi 1. The metabolism of glutamine and alanine in the lung was studied in rats made septic by a caecal ligation and puncture technique. 2. The blood glucose concentration was not significantly different in septic rats, but blood pyruvate, lactate, glutamine and alanine...
Articles
Measurement of protein synthesis in human skeletal muscle: further investigation of the flooding technique
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 557–564.
Published: 01 October 1991
...- 13 C]leucine (mean difference 0.16%/day) and l -[1- 13 C]phenylalanine (mean difference 0.2%/day). 15 3 1991 29 5 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 flooding technique leucine mass spectrometry metabolism muscle protein protein...
Articles
Effects of hypothyroidism on glucose and glutamine metabolism by the gut of the rat
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (3): 347–355.
Published: 01 September 1991
...M. Salleh M. Ardawi; Sawsan M. Jalalah 1. The metabolism of glucose and glutamine was studied in the small intestine and the colon of rats after 4–5 weeks of hypothyroidism. 2. Hypothyroidism resulted in increases in the plasma concentrations of ketone bodies ( P < 0.05), cholesterol ( P...
Articles
Effect of glutamine-enriched total parenteral nutrition on septic rats
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (2): 215–222.
Published: 01 August 1991
... of glutamine-enriched total parenteral nutrition is beneficial to septic rats and possibly to septic patients. 7 2 1991 4 3 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 amino acids glutamine metabolism muscle nitrogen balance parenteral nutrition sepsis...
Articles
Glutamine metabolism in the lungs of glucocorticoid-treated rats
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Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (1): 37–42.
Published: 01 July 1991
...M. Salleh; M. Ardawi 1. The effect of dexamethasone (30 μg day −1 100 g −1 body weight) on the regulation of glutamine metabolism was studied in the lungs of rats after 9 days of treatment. 2. Dexamethasone resulted in a negative nitrogen balance, and produced decreases in the blood concentrations...
Articles
Effect of Infused Branched-Chain Amino Acids on Muscle and Whole-Body Amino Acid Metabolism in Man
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (5): 457–466.
Published: 01 November 1990
... amino acid kinetics branched-chain amino acids leucine metabolism protein proteolysis skeletal muscle Clinical Science (1990) 79,457-466 457 Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man RITA J. LOUARD, EUGENE J. BARRETT AND ROBERT A. GELFAND...
Articles
Glutamine Metabolism in Skeletal Muscle of Glucocorticoid-Treated Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (2): 139–147.
Published: 01 August 1990
...M. Salleh M. Ardawi; Yasir S. Jamal 1. The effect of dexamethasone (30 μg day −-1 100 g −-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (2): 239–245.
Published: 01 February 1990
..., but not further metabolism, was impaired in phosphoribosylpyrophosphate synthetase-mutant cells. The Lesch–Nyhan and phosphoribosylpyrophosphate synthetase-mutant cells were unusual in that both showed no further stimulation of nucleotide synthesis at 18 mmol/l P i compared with 1 mmol/l. 3. At the high substrate...
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