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Keywords: Mitochondrial function
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 979–990.
Published: 16 April 2021
... in skeletal muscle cells and increased after exercise training. Then, IGF2 deficiency in myotubes from C2C12 and primary skeletal muscle cells (PMSCs) led to impaired mitochondrial function, reduced mitochondria-related protein content, and decreased mitochondrial biogenesis. Furthermore, we explored...
Includes: Supplementary data
Articles
Chayodom Maneechote, Siripong Palee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
...) fed groups. After feeding with either ND or HFD for 12 weeks, rats in each dietary group were divided into groups to receive either the vehicle, Mdivi1 (1.2 mg/kg, i.p.), M1 (2 mg/kg, i.p.) or combined treatment for 14 days. The cardiac function, cardiac mitochondrial function, metabolic...
Articles
Benjamin Chatel, Laurent A. Messonnier, Christophe Vilmen, Monique Bernard, Vincent Pialoux, David Bendahan
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2103–2115.
Published: 02 October 2018
... groups was observed regarding oxidative stress markers. HbSS mice displayed a higher intramuscular acidosis during the ischemic period while their mitochondrial function was impaired as compared with their HbAA and HbAS counterparts. These metabolic abnormalities could worsen the complications related...
Articles
Yuanna Ling, Guiming Chen, Yi Deng, Huixiong Tang, Long Ling, Xiaoming Zhou, Xudong Song, Pingzhen Yang, Yingfeng Liu, Zhiliang Li, Cong Zhao, Yufei Yang, Xianbao Wang, Masafumi Kitakaze, Yulin Liao, Aihua Chen
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
... Incubator Chamber) equilibrated with 95% N 2 and 5% CO 2 . Reoxygenation was then initiated by buffer exchange to normoxic complete medium alone or supplemented with 1, 10 or 100 μM PD. apoptosis autophagy ischaemia/reperfusion mitochondrial function polydatin • PD pre-treatment has...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (11): 931–941.
Published: 29 April 2016
... appears to mediate this metabolic switch. gestational diabetes mammalian target of rapamycin (mTOR) miR-143 mitochondrial function placenta As the placenta regulates nutrient composition and supply from mother to fetus and is the source of hormonal signals that affect maternal...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (7): 589–599.
Published: 14 July 2015
...Joaquin Perez-Schindler; Andrew Philp Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mitochondria display substantial plasticity...
Articles
Daniel J. Cuthbertson, Andrew Irwin, Victoria S. Sprung, Helen Jones, Christopher J. A. Pugh, Christina Daousi, Valerie L. Adams, William E. Bimson, Fariba Shojaee-Moradie, Paul Richardson, A. Margot Umpleby, John P. Wilding, Graham J. Kemp
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (12): 655–663.
Published: 08 August 2014
... by lipid deposition within the liver [intrahepatocellular lipid (IHCL)], is associated with insulin resistance and the metabolic syndrome (MS). It has been suggested that impaired skeletal muscle mitochondrial function may contribute to ectopic lipid deposition, and the associated MS, by altering post...
Articles
Ruth C. R. Meex, Esther Phielix, Vera B. Schrauwen-Hinderling, Esther Moonen-Kornips, Gert Schaart, Patrick Schrauwen, Matthijs K. C. Hesselink
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (7): 293–301.
Published: 25 June 2010
... concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus combining exercise training with statin administration may have adverse effects. We examined whether improvements in cardiometabolic risk factors, insulin sensitivity and mitochondrial function...
Includes: Supplementary data
Articles
Piero Portincasa, Ignazio Grattagliano, Bernhard H. Lauterburg, Vincenzo O. Palmieri, Giuseppe Palasciano, Frans Stellaard
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (2): 135–143.
Published: 13 July 2006
... 13 CO 2 for ketoisocaproate at 60 min was associated with the highest prediction (positive predictive value, 0.90; negative predictive value, 0.73) for NASH, yielding an overall sensitivity of 68% and specificity of 94%. In conclusion, both microsomal and mitochondrial functions are disturbed in NASH...
Articles
Stefan Heidenreich, Erich Brinkema, Andreas Martin, Rainer Düsing, Jochen Kipnowski, Herbert J. Kramer
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (6): 593–599.
Published: 01 December 1987
... and cardiac adenosine triphosphatase activities or renal cortical mitochondrial function. 4. The adenosine triphosphate content of kidney cortex and cardiac mitochondrial function were significantly depressed in CBDL rats. 5. The results demonstrate that jaundice in CBDL rats is associated with functional...