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Keywords: Mitochondrial pyruvate carrier 1
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Mingkang Li, Wenkang Zhang, Minhao Zhang, Linqing Li, Yuyu Yao, Yuhan Qin, Dong Wang, Gaoliang Yan, Yong Qiao, Chengchun Tang
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (10): 479–501.
Published: 20 May 2025
..., in vitro experiments demonstrated that knockdown or inhibition of LONP1 attenuated glycolytic reprogramming, proliferation, and migration of PASMCs, whereas overexpression of LONP1 had converse effects. Mechanistic studies confirmed that mitochondrial pyruvate carrier 1 (MPC1) was a direct substrate...
Includes: Supplementary data