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Keywords: Myocardial Infarction
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Clin Sci (Lond) (2022) 136 (10): 787–798.
Published: 27 May 2022
... model organisms myocardial infarction regeneration stem cell therapy wound healing The adult human heart is unable to functionally regenerate after injury, ultimately leading to heart failure and mortality. Heart failure affects an estimated 6 million American adults [ 1 ], making...
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Clin Sci (Lond) (2020) 134 (7): 885–888.
Published: 14 April 2020
... of the Biochemical Society 2020 Cardiac myocyte Ischemia-reperfusion injury Mitochondrial dynamics Mitochondrial fusion Myocardial infarction Heart attacks are a leading cause of death worldwide with no effective pharmacological strategies to limit permanent damage to the heart. However, accumulating...
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Clin Sci (Lond) (2019) 133 (8): 933–937.
Published: 18 April 2019
... intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Ischemic preconditioning (IPC) is defined by episodes of ‘sub-lethal’ ischemia...
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Clin Sci (Lond) (2019) 133 (3): 425–441.
Published: 05 February 2019
... facilitated CM proliferation. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of CMs. Supperession of let-7i-5p promoted the recovery of heart function post-myocardial infarction by enhancing E2F2 and CCND2. Collectively, our results revealed...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (24): 2547–2564.
Published: 13 December 2018
... This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . myocardial infarction orexins orexin receptors Cardiovascular disease (CVD), including myocardial infarction...
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Clin Sci (Lond) (2017) 131 (17): 2303–2317.
Published: 10 August 2017
... and its pathophysiological mechanisms following acute myocardial infarction (MI) in adult rat offspring exposed to prenatal hypoxia. Male and female rat offspring, which experienced normoxia (21% O 2 ) or hypoxia (11% O 2 ) in utero underwent sham or MI surgery at 12 weeks of age. Echocardiographic data...
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Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Published: 31 May 2017
... in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular...
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Clin Sci (Lond) (2016) 130 (7): 463–478.
Published: 17 February 2016
... ]. The recruited mononuclear cells trigger activation of inhibitory pathways, mostly directed by the cytokine TGF-β, suppressing the inflammatory state while inducing cardiac fibrosis [ 30 ]. Hence, MCP-1 downstream signalling post-myocardial infarction (MI) initially activates a pro-inflammatory response, which...
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Clin Sci (Lond) (2014) 127 (3): 149–161.
Published: 03 April 2014
... and atherosclerosis. Although initial studies over a decade ago reported increases in circulating MIF levels following acute MI (myocardial infarction), the dynamic changes in MIF and its pathophysiological significance following MI have been unknown until recently. In the present review, we summarize recent...
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Clin Sci (Lond) (2013) 124 (2): 65–76.
Published: 12 September 2012
... 2013 angiotensin-converting enzyme 2 (ACE2) coronary artery disease hypertension left ventricular hypertrophy myocardial infarction renin–angiotensin system (RAS) The RAS (renin–angiotensin system) plays a major role in the pathophysiology of CVD (cardiovascular disease) [ 1 , 2...
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Clin Sci (Lond) (2011) 121 (1): 1–10.
Published: 18 March 2011
... are expressed in other tissues such as those of the cardiovascular system. In the present review, the role of TLRs in septic cardiomyopathy, viral myocarditis, atherosclerosis, ischaemia/reperfusion injury and cardiac remodelling after myocardial infarction are outlined, with attention paid to genetically...
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Clin Sci (Lond) (2011) 120 (9): 377–402.
Published: 18 January 2011
... hypoxia, ischaemia and oxidative stress, thus mediating functional homoeostatic adjustments. In contrast, its deprivation results in apoptosis and dysfunction. Many prospective epidemiological surveys have associated low IGF-1 levels with late mortality, MI (myocardial infarction), HF (heart failure...
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Clin Sci (Lond) (2011) 120 (6): 231–238.
Published: 03 December 2010
...Leong L. Ng; Sohail Q. Khan; Hafid Narayan; Paulene Quinn; Iain B. Squire; Joan E. Davies A multimarker approach may be useful for risk stratification in AMI (acute myocardial infarction) patients, particularly utilizing pathways that are pathophysiologically distinct. Our aim was to assess...
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Clin Sci (Lond) (2010) 118 (10): 593–605.
Published: 23 February 2010
... atherosclerosis heart failure myocardial infarction nuclear factor-κB (NF-κB) percutaneous coronary intervention (PCI) vein grafting The NF-κB family ( Figure 1 ) consists of five members: p65 ( RelA ), RelB ( RelB ), c-Rel ( Rel ), p105/p50 ( NFKB1 ) and p100/p52 ( NFKB2 ). All members share an N...
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Clin Sci (Lond) (2010) 118 (4): 249–257.
Published: 09 November 2009
... coronary syndrome for death, readmission with HF (heart failure) or recurrent MI (myocardial infarction) and to compare them with established markers, NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the GRACE (Global Registry of Acute Coronary Events) score. A single blood test was taken 4 days...
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Clin Sci (Lond) (2009) 117 (1): 13–15.
Published: 02 June 2009
..., for the prediction of mortality after acute myocardial infarction, using a combination of statistical methods. Correspondence: Professor Torbjørn Omland (email torbjorn.omland@medisin.uio.no ). 26 3 2009 7 4 2009 7 4 2009 © The Authors Journal compilation © 2009 Biochemical Society...
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Clin Sci (Lond) (2009) 116 (1): 37–39.
Published: 28 November 2008
...@web.de ). 13 10 2008 29 10 2008 29 10 2008 © The Authors Journal compilation © 2009 Biochemical Society 2009 atorvastatin heart failure inflammation interleukin-10 myocardial infarction Statins can lower serum cholesterol levels. That fact is beyond doubt. Patients...
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Clin Sci (Lond) (2008) 115 (7): 203–218.
Published: 03 September 2008
... myocardial infarction, atherosclerosis and vascular restenosis will be examined, with attention paid to genetically modified murine model systems and to the use of pharmacological inhibitors of protein kinases. Despite the complexities of this field of research, attractive targets for pharmacological therapy...
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Clin Sci (Lond) (2008) 115 (4): 129–131.
Published: 15 July 2008
... in coronary artery disease. HSP heat-shock protein LPS lipopolysaccharide MI myocardial infarction AMI acute MI SA stable angina TLR Toll-like receptor References 1 Ishikawa Y. Satoh M. Itoh T. Minami Y. Takahashi Y. Nakamura M. Local...
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