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1-36 of 36
Keywords: NADPH oxidase
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Cardiovascular-Oncology
Katrina M. Mirabito Colafella, Daan C.H. van Dorst, Rugina I. Neuman, Leni van Doorn, Karla Bianca Neves, Augusto C. Montezano, Ingrid M. Garrelds, Richard van Veghel, René de Vries, Estrellita Uijl, Marian C. Clahsen-van Groningen, Hans J. Baelde, Anton H. van den Meiracker, Rhian M. Touyz, Willy Visser, A.H. Jan Danser, Jorie Versmissen
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (9): 675–694.
Published: 10 May 2022
... endothelins hypertension NADPH oxidase vascular endothelial growth factor Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is essential for tumour growth and metastatic spread. Inhibition of angiogenesis by targeting the vascular endothelial growth factor (VEGF...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (5): 379–382.
Published: 11 March 2022
... with Portland Press and the Biochemical Society under a transformative agreement with EBSCO. eNOS endothelial nitric oxide synthase HS heparan sulfate NOX1/4 NADPH oxidase 1/4 OPG osteoprotegerin RANKL receptor activator of nuclear factor-κB ligand ROS reactive oxygen...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Hepatic fibrosis NADPH oxidase Oxidative stress...
Includes: Supplementary data
Articles
Rhéure Alves-Lopes, Karla Bianca Neves, Anastasiya Strembitska, Adam P. Harvey, Katie Y. Harvey, Hiba Yusuf, Susan Haniford, Ross T. Hepburn, Jennifer Dyet, Wendy Beattie, Laura Haddow, John McAbney, Delyth Graham, Augusto C. Montezano
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (20): 2429–2444.
Published: 28 October 2021
... activation of syndecan-1 and NADPH oxidases (Noxs) 1 and 4. Isolated resistance arteries from Wistar–Kyoto (WKY) rats, exposed to exogenous OPG, studied by myography exhibited endothelial and smooth muscle dysfunction. OPG decreased nitric oxide (NO) production, eNOS activation and increased reactive oxygen...
Includes: Supplementary data
Articles
Josiane Fernandes da Silva, Juliano V. Alves, Julio A. Silva-Neto, Rafael M. Costa, Karla B. Neves, Rheure Alves-Lopes, Livia L. Carmargo, Francisco J. Rios, Augusto C. Montezano, Rhian M. Touyz, Rita C. Tostes
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1845–1858.
Published: 04 August 2021
[email protected] ) 11 05 2021 02 07 2021 16 07 2021 16 07 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 Endothelial cells Lysophosphatidylcholine NADPH oxidase NOX5 Oxidative stress Atherosclerosis remains...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1675.
Published: 06 July 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Alamandine Angiotensin II Autophagy Hepatic fibrosis NADPH oxidase...
Articles
Yun Huang, Yang Li, Anni Lou, Guo zhen Wang, Ye Hu, Yijie Zhang, Weichang Huang, Jun Wang, Yue Li, Xintao Zhu, Tingting Chen, Jiayi Lin, Ying Meng, Xu Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
Articles
Rachel Njeim, Theresa Farhat, Sahar Alkhansa, Natalie Youssef, Batoul Dia, Rasha Slika, Radwan Diab, Sami T. Azar, Assaad A. Eid
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... 02 2020 10 02 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Adipose Inflammation Diabetes Diabetic Kidney Disease NADPH oxidase obesity Oxidative Stress Diabetes mellitus (DM) [ 1 ] is one of the major public...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2109–2123.
Published: 24 July 2017
.... Soluble parenchymal Aβ was associated with elevated NADPH oxidase-2 (NOX2) which was exacerbated by 1-month hypoperfusion. We suggest that in response to hypoperfusion, increased Aβ production/deposition may contribute to degenerative processes by triggering oxidative stress promoting cerebrovascular...
Includes: Supplementary data
Articles
Imad Al Ghouleh, Sanghamitra Sahoo, Daniel N. Meijles, Jefferson H. Amaral, Daniel S. de Jesus, John Sembrat, Mauricio Rojas, Dmitry A. Goncharov, Elena A. Goncharova, Patrick J. Pagano
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2019–2035.
Published: 17 July 2017
... measured using cytochrome c and Amplex Red assays. Findings demonstrate for the first time an up-regulation of NADPH oxidase 1 (Nox1) at the transcript and protein level in resistance vessels from PAH compared with non-PAH patients. This coincided with an increase in ROS production and expression of bone...
Articles
Elyse Di Marco, Stephen P. Gray, Phyllis Chew, Kit Kennedy, Mark E. Cooper, Harald H.H.W. Schmidt, Karin A.M. Jandeleit-Dahm
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (15): 1363–1374.
Published: 29 June 2016
... of vascular reactive oxygen species (ROS), NADPH oxidase (NOX) enzymes and immune-inflammatory processes remain to be fully elucidated. In the present study we investigated the roles of the NADPH oxidase subunit isoforms, NOX4 and NOX1, in immune cell activation and recruitment to the aortic sinus...
Includes: Supplementary data
Articles
Elsa C. Chan, Peter van Wijngaarden, Elsie Chan, Darleen Ngo, Jiang-Hui Wang, Hitesh M. Peshavariya, Gregory J. Dusting, Guei-Sheung Liu
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (9): 683–696.
Published: 18 March 2016
... typically occurs in response to corneal injury such as that caused by infection, physical trauma, chemical burns or in the setting of corneal transplant rejection. The NADPH oxidase enzyme complex is involved in cell signalling for wound-healing angiogenesis, but its role in corneal neovascularization has...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (7): 479–490.
Published: 17 February 2016
...Kelly L. Singel; Brahm H. Segal NADPH oxidase (NOX) isoforms together have multiple functions that are important for normal physiology and have been implicated in the pathogenesis of a broad range of diseases, including atherosclerosis, cancer and neurodegenerative diseases. The phagocyte NADPH...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (3): 151–165.
Published: 17 December 2015
...Marcela Gimenez; Brandon M. Schickling; Lucia R. Lopes; Francis J. Miller, Jr Since its discovery in 1999, a number of studies have evaluated the role of Nox1 NADPH oxidase in the cardiovascular system. Nox1 is activated in vascular cells in response to several different agonists, with its activity...
Articles
Marta Toral, Miguel Romero, Rosario Jiménez, Ayman Moawad Mahmoud, Emma Barroso, Manuel Gómez-Guzmán, Manuel Sánchez, Ángel Cogolludo, Ana B. García-Redondo, Ana M. Briones, Manuel Vázquez-Carrera, Francisco Pérez-Vizcaíno, Juan Duarte
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (9): 823–837.
Published: 07 August 2015
... relaxation, phosphorylation of eNOS at Ser 1177 , and increased ROS production and NADPH oxidase in mice fed on a high-fat diet. The PPARβ/δ antagonist GSK0660 abolished all of these protective effects induced by GW0742. This agonist enhanced the expression of CPT (carnitine palmitoyltransferase)-1...
Includes: Supplementary data
Articles
Krishnendu Roy, Yongzhong Wu, Jennifer L. Meitzler, Agnes Juhasz, Han Liu, Guojian Jiang, Jiamo Lu, Smitha Antony, James H. Doroshow
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (12): 863–875.
Published: 27 March 2015
... of the family of NADPH oxidases (NOXs 1–5 and dual oxidases DUOX1/2) which are structural homologues of gp91 phox , the major membrane-bound component of the respiratory burst oxidase of leucocytes. Knowledge of the roles of the NOX isoforms in cancer is rapidly expanding. Recent evidence suggests that both...
Articles
Mauricio Krause, Patricia Martins Bock, Hilton Kenji Takahashi, Paulo Ivo Homem De Bittencourt, Jr, Philip Newsholme
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (11): 789–803.
Published: 19 March 2015
...-cell dysfunction/death. In the present review, we describe possible mechanisms by which HSP70 participates in cell function/dysfunction, including the activation of NADPH oxidase isoforms leading to oxidative stress, focusing on the possible role of HSPs and signalling in pancreatic islet α- and β-cell...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (8): 465–481.
Published: 23 December 2014
... [email protected] ). 9 6 2014 8 10 2014 13 11 2014 © The Authors Journal compilation © 2015 Biochemical Society 2015 NADPH oxidase reactive oxygen species renal disease Ongoing reactive oxygen species (ROS) generation is required to sustain physiological...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (6): 337–347.
Published: 28 November 2014
...Nathalie Grandvaux; Mélissa Mariani; Karin Fink Determining the role of NADPH oxidases in the context of virus infection is an emerging area of research and our knowledge is still sparse. The expression of various isoforms of NOX/DUOX (NADPH oxidase/dual oxidase) in the epithelial cells (ECs...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (5): 331–340.
Published: 15 May 2014
.... In the present study, we have shown that human dilated cardiomyopathy is associated with increased NOX2 (NADPH oxidase 2) levels, increased oxidative stress with adverse myocardial remodelling and activation of MAPKs (mitogen-activated protein kinases). Advanced heart failure in mice was also associated...
Articles
Marta Toral, Manuel Gómez-Guzmán, Rosario Jiménez, Miguel Romero, Manuel Sánchez, María Pilar Utrilla, Natividad Garrido-Mesa, María Elena Rodríguez-Cabezas, Mónica Olivares, Julio Gálvez, Juan Duarte
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (1): 33–45.
Published: 10 March 2014
...- and NO (nitric oxide)-dependent vasodilatation induced by acetylcholine in aortic rings was studied. It also restored the increased vessel superoxide levels observed in obese mice, by reducing NADPH oxidase activity and increasing antioxidant enzymes. Moreover, chronic probiotic administration for 2 weeks also...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (2): 111–121.
Published: 13 September 2013
... between NADPH oxidase and mitochondria, the main ROS sources in hypertension, which may represent a vicious feed-forward cycle of ROS production. In recent years, there is experimental evidence showing a relationship between ROS and COX-derived products. Thus ROS can activate COX and the COX/PG...
Articles
María U. Moreno, Idoia Gallego, Begoña López, Arantxa González, Ana Fortuño, Gorka San José, Félix Valencia, Juan José Gómez-Doblas, Eduardo de Teresa, Ajay M. Shah, Javier Díez, Guillermo Zalba
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (6): 291–300.
Published: 22 May 2013
...María U. Moreno; Idoia Gallego; Begoña López; Arantxa González; Ana Fortuño; Gorka San José; Félix Valencia; Juan José Gómez-Doblas; Eduardo de Teresa; Ajay M. Shah; Javier Díez; Guillermo Zalba The NADPH oxidases are a key family of ROS (reactive oxygen species)-producing enzymes which may...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (10): 597–615.
Published: 04 February 2013
... synthase. The family of NADPH oxidase (Nox) enzymes are likely to be important given that their primary function is to produce ROS. Seven isoforms of Nox have been identified named Nox1–5, Duox (dual oxidase) 1 and Duox2. Nox1, Nox2 and Nox4 have been most extensively studied and are implicated...
Articles
Mona Sedeek, Alex Gutsol, Augusto C. Montezano, Dylan Burger, Aurelie Nguyen Dinh Cat, Chris R. J. Kennedy, Kevin D. Burns, Mark E. Cooper, Karin Jandeleit-Dahm, Patrick Page, Cedric Szyndralewiez, Freddy Heitz, Richard L. Hebert, Rhian M. Touyz
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (3): 191–202.
Published: 17 October 2012
...Mona Sedeek; Alex Gutsol; Augusto C. Montezano; Dylan Burger; Aurelie Nguyen Dinh Cat; Chris R. J. Kennedy; Kevin D. Burns; Mark E. Cooper; Karin Jandeleit-Dahm; Patrick Page; Cedric Szyndralewiez; Freddy Heitz; Richard L. Hebert; Rhian M. Touyz Nox (NADPH oxidase)-derived ROS (reactive oxygen...
Includes: Supplementary data
Articles
María Cecilia Castro, Flavio Francini, Guillermo Schinella, Claudia Inés Caldiz, María Guillermina Zubiría, Juan José Gagliardino, María Laura Massa
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (12): 681–692.
Published: 10 August 2012
...María Cecilia Castro; Flavio Francini; Guillermo Schinella; Claudia Inés Caldiz; María Guillermina Zubiría; Juan José Gagliardino; María Laura Massa In the present study, we investigated the role of NADPH oxidase in F (fructose)-rich-diet-induced hepatic OS (oxidative stress) and metabolic changes...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (7): 305–312.
Published: 07 June 2011
... factor)-α and IL (interleukin)-6 were evaluated by real-time PCR and Western blotting in SHRs (spontaneously hypertensive rats), diabetic SHRs, diabetic SHRs treated with RGZ (5 mg/kg of body weight) and control WKY (Wistar–Kyoto) rats. Cardiac NADPH oxidase activity was quantified using a SOD...
Articles
Rocío López-Sepúlveda, Manuel Gómez-Guzmán, Maria José Zarzuelo, Miguel Romero, Manuel Sánchez, Ana María Quintela, Pilar Galindo, Francisco O'Valle, Juan Tamargo, Francisco Pérez-Vizcaíno, Juan Duarte, Rosario Jiménez
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (8): 321–333.
Published: 22 December 2010
..., increased intracellular O 2 •− production, NADPH oxidase activity and protein expression of NADPH oxidase subunit p47 phox . All these changes were prevented by RWPs. The preventive effects of RWPs were unaffected by co-incubation with either ICI-182780, an ER (oestrogen receptor) antagonist, or GW9662...
Articles
Gorka San José, Ana Fortuño, María U. Moreno, Pablo A. Robador, Julen Bidegain, Nerea Varo, Oscar Beloqui, Javier Díez, Guillermo Zalba
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (3): 233–240.
Published: 08 January 2009
... polymorphism was determined by PCR. NADPH oxidase-dependent O 2 •− production was quantified in phagocytic cells by chemiluminescence. MMP-9 (matrix metalloproteinase-9), a marker of atherosclerosis previously reported to be associated with NADPH oxidase overactivity, was quantified by ELISA in plasma samples...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (3): 173–182.
Published: 08 January 2008
... the cardiovascular system, a family of multisubunit NADPH oxidases appears to be a predominant contributor of superoxide anion. Recent findings suggest a significant role of the genetic background in NADPH oxidase regulation. Common genetic polymorphisms within the promoter and exonic sequences of CYBA , the gene...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (1): 1–20.
Published: 14 June 2006
...Mark T. Quinn; Mary Cloud B. Ammons; Frank R. DeLeo The NADPH oxidase was originally identified as a key component of human innate host defence. In phagocytes, this enzyme complex is activated to produce superoxide anion and other secondarily derived ROS (reactive oxygen species), which promote...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 205–206.
Published: 17 January 2006
... hypertension mitochondria NADPH oxidase reactive oxygen species (ROS) A major focus within the basic science community studying hypertension is related to the role of ROS (reactive oxygen species). The broad definition of ROS includes oxygen-containing species that are all capable of reacting...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 243–253.
Published: 17 January 2006
... hypertension through NADPH-oxidase-dependent mechanisms. Xanthine oxidase, eNOS (endothelial nitric oxide synthase) and COX-2 (cyclo-oxygenase-2) were also examined as potential ET-1 sources of ROS as well as mitochondrial respiration. DOCA-salt and control UniNX (uninephrectomized) rats were treated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 277–286.
Published: 24 August 2005
... of the present study was to examine the effect of dietary iron deficiency on cardiac ultrastructure, mitochondrial cytochrome c release, NOS (nitric oxide synthase) and several stress-related protein molecules, including protein nitrotyrosine, the p47 phox subunit of NADPH oxidase, caveolin-1 and RhoA. Male...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (3): 217–226.
Published: 24 August 2005
...Robin Ray; Ajay M. Shah Intracellular ROS (reactive oxygen species) such as superoxide and H 2 O 2 have been increasingly appreciated to have a role in endothelial pathophysiology. Of the several sources within the vasculature, a family of multi-subunit NADPH oxidases appears to be a predominant...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (4): 403–408.
Published: 09 September 2002
...Tania Cristina PITHON-CURI; Adriana C. LEVADA; Lúcia R. LOPES; Sonia Q. DOI; Rui CURI The effect of glutamine on the activity of the NADPH oxidase complex from rat neutrophils was investigated. Superoxide anion (O 2 - ) production was assessed: (1) by scintillation counting by using lucigenin...
