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Keywords: NADPH oxidase (Nox)
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Articles

Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways

Thiago Bruder-Nascimento, Glaucia E. Callera, Augusto C. Montezano, Ying He, Tayze T. Antunes, Aurelie Nguyen Dinh Cat, Rita C. Tostes, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (7): 411–423.
https://doi.org/10.1042/CS20140456
Published: 09 December 2014
..., which underlie vascular damage in diabetes. Statins are cholesterol-lowering drugs that are vasoprotective in diabetes through unknown mechanisms. We tested the hypothesis that atorvastatin decreases NADPH oxidase (Nox)-derived ROS generation and associated vascular injury in diabetes. Lepr db /Lepr db...
View article titled, Vascular injury in diabetic db/db mice is ameliorated by atorvastatin: role of Rac1/2-sensitive Nox-dependent pathways
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Includes: Supplementary data
Articles

Valsartan slows the progression of diabetic nephropathy in db / db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation

Guangyu Zhou, Alfred K. Cheung, Xia Liu, Yufeng Huang
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (10): 707–720.
https://doi.org/10.1042/CS20130223
Published: 27 January 2014
... nephropathy inflammation NADPH oxidase (Nox) podocyte • Higher doses of AngII blockade are intended to optimize albuminuria reduction rather than for blood pressure control in patients with chronic kidney disease; however, the long-term renoprotection of high-dose AngII blockers has yet...
View article titled, Valsartan slows the progression of diabetic nephropathy in db / db mice via a reduction in podocyte injury, and renal oxidative stress and inflammation
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Articles

Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis

Ji-Youn Youn, Andrew Nguyen, Hua Cai
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (8): 509–518.
https://doi.org/10.1042/CS20110407
Published: 29 June 2012
[email protected] ). 12 8 2011 8 5 2012 8 5 2012 8 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 combinatorial therapy diethylstilbestrol (DES) LNCaP cell NADPH oxidase (NOX) nitric oxide reactive oxygen species superoxide anion xanthine oxidase...
View article titled, Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis
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Articles

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

Augusto C. Montezano, Dylan Burger, Graziela S. Ceravolo, Hiba Yusuf, Maria Montero, Rhian M. Touyz
Journal: Clinical Science
Clin Sci (Lond) (2011) 120 (4): 131–141.
https://doi.org/10.1042/CS20100384
Published: 02 November 2010
... in vascular biology. Correspondence: Dr Augusto C. Montezano (email [email protected] ). 20 7 2010 1 9 2010 14 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 endothelium hydrogen peroxide NADPH oxidase (Nox) reactive oxygen species superoxide...
View article titled, Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5
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