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Keywords: NF-κB
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Clin Sci (Lond) (2022) 136 (24): 1877–1891.
Published: 22 December 2022
..., whereas they were alleviated by PARK7 overexpression. Mechanistically, silencing Park7 facilitated nuclear translocation and phosphorylation of p65 (a key component of the nuclear factor kappa B [NF-κB] complex) during LPS treatment, whereas PARK7 overexpression partially prevented these changes. Moreover...
Clin Sci (Lond) (2019) 133 (20): 2045–2059.
Published: 16 October 2019
... in vivo and in vitro findings demonstrated, for the first time, that endogenous H 2 S directly inactivated IKKβ via sulfhydrating IKKβ at Cys 179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH. Figure 1 MCTP down-regulated the endogenous H 2 S/CSE...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (15): 1339–1352.
Published: 29 June 2016
... unclear. In the present study, we demonstrate for the first time that 1,8-cineole potentiates poly(I:C)-induced activity of the antiviral transcription factor interferon regulatory factor 3 (IRF3), while simultaneously reducing proinflammatory nuclear factor (NF)-κB activity in human cell lines, inferior...
Includes: Supplementary data
Clin Sci (Lond) (2002) 103 (s2002): 68S–71S.
Published: 01 September 2002
... injury. We also found that FK409 substantially reduced endothelin-1 (ET-1) production in cultured vascular endothelial cells (ECs). Nuclear factor κB (NF-κB) is known to play a key role in the development of ischaemic disorders through regulation of the expression of a variety of genes. In the present...