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Keywords: NLRP3
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Clin Sci (Lond) (2023) 137 (5): 333–351.
Published: 01 March 2023
... will focus on the role of NACHT, leucin-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome in the pathophysiology of sepsis. NLRP3 inflammasome is a multiproteic intracellular complex activated by infectious pathogens through a two-step process resulting in the release of the pro-inflammatory...
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
.... The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD + metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging...