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Keywords: NLRP3
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Articles
Clin Sci (Lond) (2023) 137 (5): 333–351.
Published: 01 March 2023
... will focus on the role of NACHT, leucin-rich repeat and pyrin-containing protein 3 (NLRP3) inflammasome in the pathophysiology of sepsis. NLRP3 inflammasome is a multiproteic intracellular complex activated by infectious pathogens through a two-step process resulting in the release of the pro-inflammatory...
Articles
Clin Sci (Lond) (2022) 136 (4): 273–289.
Published: 21 February 2022
...Bohao Liu; Zhong Wang; Ruyuan He; Rui Xiong; Guorui Li; Lin Zhang; Tinglv Fu; Chenyuan Li; Ning Li; Qing Geng Background : NOD-like receptor family pyrin domain containing 3 (NLRP3)-mediated macrophage pyroptosis plays an important role in sepsis-induced acute lung injury (ALI). Inhibition...
Includes: Supplementary data
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Articles
Clin Sci (Lond) (2020) 134 (17): 2243–2262.
Published: 03 September 2020
.... The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD + metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging...
Articles
Clin Sci (Lond) (2019) 133 (17): 1901–1916.
Published: 13 September 2019
...Tárcio Teodoro Braga; Wesley Nogueira Brandao; Hatylas Azevedo; Fernanda Fernandes Terra; Amanda Campelo L. Melo; Felipe Valença Pereira; Vinicius Andrade-Oliveira; Meire Ioshie Hiyane; Jean Pierre S. Peron; Niels Olsen Saraiva Camara NLRP3 inflammasome [NLR (nucleotide-binding domain, leucine-rich...
Includes: Supplementary data