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Keywords: NOX2
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Articles

NADPH oxidase 2 plays a role in experimental corneal neovascularization

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Elsa C. Chan, Peter van Wijngaarden, Elsie Chan, Darleen Ngo, Jiang-Hui Wang, Hitesh M. Peshavariya, Gregory J. Dusting, Guei-Sheung Liu
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (9): 683–696.
https://doi.org/10.1042/CS20150103
Published: 18 March 2016
... not been studied. We have now analysed the role of the Nox2 isoform of NADPH oxidase in corneal neovascularization in mice following chemical injury. C57BL/6 mice aged 8–14 weeks were cauterized with an applicator coated with 75% silver nitrate and 25% potassium nitrate for 8 s. Neovascularization...
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Includes: Supplementary data
Articles

NOX2-dependent regulation of inflammation

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Kelly L. Singel, Brahm H. Segal
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (7): 479–490.
https://doi.org/10.1042/CS20150660
Published: 17 February 2016
... oxidase (NOX2) is critical for antimicrobial host defence. Chronic granulomatous disease (CGD) is an inherited disorder of NOX2 characterized by severe life-threatening bacterial and fungal infections and by excessive inflammation, including Crohn's-like inflammatory bowel disease (IBD). NOX2 defends...
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