...Man K.S. Lee; Gopalkrishna Sreejit; Prabhakara R. Nagareddy; Andrew J. Murphy In volume 133 issue 4 of Clinical Science , Liu et al. showed that neutrophils release extracellular traps (NETs) in the setting of diabetes which acts as a stimulus for NLRP3 inflammasome activation in macrophages...

...Alain R. Thierry; Benoit Roch We demonstrate that the general clinical conditions, risk factors and numerous pathological and biological features of COVID-19 are analogous with various disorders caused by the uncontrolled formation of neutrophil extracellular traps and their by-products. Given...

... inflammation. A strong acute inflammatory response characterized by neutrophilic influx, increased cytokine secretion [KC (keratinocyte chemoattractant), TNF-α (tumour necrosis factor α), MIP-2 (macrophage inflammatory protein 2), MIP-1α and MCP-1 (monocyte chemoattractant protein-1)], pro-inflammatory gene...

... of MetS was significantly higher in VTE (38.3%) than in control individuals (21.3%) with an adjusted OR (odds ratio) for VTE of 1.96 ( P =0.002). VTE patients had higher circulating neutrophils ( P <0.0001), while the CD34 + cell count was significantly lower among patients with unprovoked VTE compared...

...-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. myeloperoxidase myocardial infarction neutrophil peptide prognosis proteinase 3 Atherosclerosis is associated with inflammatory changes in the blood vessel wall [ 1 ], including...

... disease, and at sites of anaerobic infection. In the present study, the effect of the SCFAs acetate, propionate and butyrate on neutrophil chemotaxis and migration was investigated. Experiments were carried out in rats and in vitro . The following parameters were measured: rolling, adherence, expression...

...Stephen M. Bianchi; David H. Dockrell; Stephen A. Renshaw; Ian Sabroe; Moira K. B. Whyte Apoptosis, programmed cell death, of neutrophil and eosinophil granulocytes is a potential control point in the physiological resolution of innate immune responses. There is also increasing evidence...

...Daniel D. MELLEY; Timothy W. EVANS; Gregory J. QUINLAN SIRS (systemic inflammatory response syndrome) may result from a wide variety of non-infective insults. Surgery is a recognized cause of SIRS, the onset of which can have adverse prognostic significance. Neutrophil activation is a key...

...Julie M. WILLIAMS; Lavanya KAMESH; Caroline O. S. SAVAGE ANCA (anti-neutrophil cytoplasm antibody)-associated small vessel vasculitis is an inflammatory condition associated with the production of autoantibodies to neutrophil cytoplasmic components. The disorder results in destruction...

... 22 4 2003 2 5 2003 2 5 2003 © 2003 The Biochemical Society 2003 apoptosis fetuin macrophage neutrophil phagocytosis Clinical Science (2003) 105, 273 278 (Printed in Great Britain) 273 Fetuin/ 2-HS glycoprotein enhances phagocytosis of apoptotic cells...

... macrophage neutrophil phagocytosis Clinical Science (2003) 105, 267 268 (Printed in Great Britain) 267 C O M M E N T A physiological role for 2-HS glycoprotein: stimulation of macrophage uptake of apoptotic cells A B S T R A C T This comment describes the study by Jersmann and co-workers in this issue...

...James H. WILLIAMS, JR; Madeleine V. PAHL; Donna KWONG; Jeng ZHANG; Denise HATAKEYAMA; Khawaja AHMAD; Majid NADERI; Minh KIM; Nosratola VAZIRI Complement receptor 3 (CR3; CD18/CD11b) plays an important role in the recognition and clearance of Streptococcus pneumoniae (pneumococci) by neutrophils...

... (Printed in Great Britain) Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line Declan A. HEALY R. William G. WATSON and Philip NEWSHOLME* *Department of Biochemistry, University College...

... of neutrophil granulocytes is an important determinant of the resolution of inflammation, providing a mechanism for down-regulation of function and triggering clearance by macrophages without inducing a pro-inflammatory response. However, if the rate of cell death by apoptosis is such that the macrophage...

...Tania Cristina PITHON-CURI; Adriana C. LEVADA; Lúcia R. LOPES; Sonia Q. DOI; Rui CURI The effect of glutamine on the activity of the NADPH oxidase complex from rat neutrophils was investigated. Superoxide anion (O 2 - ) production was assessed: (1) by scintillation counting by using lucigenin...

..., mononuclear cells and neutrophils in broncho-alveolar lavage fluid 4h after injection. Bosentan and Ro 46-8443 (at doses of 30 and 10mg·kg -1 respectively) inhibited the neutrophil infiltration induced by oleic acid by approx. 80%. None of the antagonists modified control (basal) pulmonary microvascular...

... the respiratory burst in polymorphonuclear neutrophils (PMNs), but the underlying mechanisms remain unclear. OKG is usually recognized as generating glutamine, arginine and polyamines. The aim of the present study was first to determine the effects of OKG on PMN bactericidal functions (chemotaxis and respiratory...

...Nicholas J.M. FARDON; Robert WILKINSON; Trevor H. THOMAS Microalbuminuria in Type I diabetes involves a cell membrane abnormality and is associated with a large increase in cardiovascular risk. The hypothesis that the membrane abnormality alters granule exocytosis in neutrophils, which could...

...-methionyl-leucyl-phenylalanine (fMLP), interact with epithelial cells inducing the release of chemokines, including interleukin-8 (IL-8), which in turn leads to the recruitment of neutrophils which release mucin secretagogues; (ii) that fMLP acts directly on epithelial cells to cause mucus secretion...

... that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1β, tumour necrosis factor-α and C-reactive protein were...

...Marcus K. Ilton; Marcia L. Taylor; Neil L. A. Misso; Philip J. Thompson; Joseph Hung 1. Close contact between platelets and neutrophils modulates their cellular interactions in thrombotic and inflammatory states, with stimulation of P-selectin expression on platelets by agonists such as thrombin...

...A. T. Cole; N. M. Garlick; A. M. Galvin; C.J. Hawkey; R. A. Robins 1. We report a flow cytometric method in which changes in forward angle light scatter are shown to correlate with microscopically evaluated shape change in stimulated human neutrophils. Neutrophil movement and chemotaxis...

...Tak H. Lee; Claire E. Horton; U. Kyan-Aung; Dorian Haskard; Atttlio E. G. Crea; Bernd W. Spur 1. Lipoxin A 4 (LXA 4 ) and lipoxin B 4 (LXB 4 ) have been evaluated for their capacities to modulate neutrophil (PMN) migration and endothelial cell adherence using compounds prepared by total chemical...

...David Burnett; Anita Chamba; Susan L. Hill; Robert A. Stockley 1. Neutrophils from patients with chronic obstructive bronchitis and emphysema or age-matched control subjects were cultured on a substrate of 125 I-fibronectin. The neutrophils from patients with lung disease digested significantly...

... abnormal results, suggesting that the test procedure may be of value as a screening procedure for this disease. 5 5 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 chronic granulomatous disease leucocyte monocyte phagocyte neutrophil Nitroblue Tetrazolium...