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Keywords: Oxidative stress
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Clin Sci (Lond) (2022) 136 (13): 1019–1023.
Published: 01 July 2022
...Philip C. Calder Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease globally. The first stage of NAFLD is steatosis, the accumulation of triacylglycerols within hepatocytes. Inflammation and oxidative stress both contribute to progression to more severe disease. In 2004...
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Clin Sci (Lond) (2022) 136 (6): 405–423.
Published: 23 March 2022
... and COPD involve significant local (i.e. lung, vasculature) and systemic inflammation and oxidative stress, of which current pharmacological treatments have limited efficacy, hence the urgency for the development of novel life-saving therapeutics. Currently these diseases must be treated individually...
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Clin Sci (Lond) (2022) 136 (2): 167–180.
Published: 20 January 2022
... oxidative stress as well as increased mesangial expansion and glomerulosclerosis when compared with vehicle-treated diabetic animals. Inhibition of the inflammasome by MCC950 in diabetic mice led to renal up-regulation of markers of inflammation ( Il1 β, Il18 and Mcp1 ), fibrosis ( Col1, Col4 , Fn1, α-SMA...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (24): 2665.
Published: 15 December 2021
... are presented as mean ± SEM. * P <0.05 versus CTR; # P <0.05 versus the Ang II treatment group; ▲ P <0.05 versus the BA treatment group. Abbreviations: CTR, control. Figure 4 Alamandine suppresses Ang II-induced collagen production by inhibiting oxidative stress in HSCs HSCs were...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (10): 1251–1272.
Published: 26 May 2021
... Biomimetics chronic kidney disease Inflammation life style diseases oxidative stress Human life expectancy has achieved an unprecedented rise, at a rate of 5 years per decade, since the beginning of the millennium. The population aged 65 years or over is projected to reaching 1.5 billion in 2050...
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Clin Sci (Lond) (2021) 135 (4): 613–627.
Published: 18 February 2021
... extracellular matrix (ECM) synthesis and significantly inhibited HG-induced HaCaT cell damage. Further analysis indicated that BBR activated TrxR1, suppressed its downstream JNK signaling, thereby inhibiting oxidative stress and apoptosis, promoted cell proliferation, down-regulated matrix metalloproteinase...
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Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
... quality of life. Loss in muscle mass cannot alone account for the muscle weakness induced by RA, but instead intramuscular dysfunction appears as a critical factor underlying the decreased force generating capacity for patients afflicted by arthritis. Oxidative stress and associated oxidative post...
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Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... oxidative stress and neuronal apoptosis, as well as decreased accumulation of Aβ and Tau in the hippocampus. Taken together, the data demonstrated that transplantation of Mito-Plt attenuated cognitive impairment and mitochondrial dysfunction in db/db mice. This method may be a potential therapeutic...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (13): 1613–1629.
Published: 30 June 2020
... and oxygen-induced retinopathy (OIR) models. The retina function was monitored by electroretinography (ERG) and retinal thickness was measured by optical coherence tomography (OCT). TUNEL and cell death ELISA were performed to measure the apoptosis. Oxidative stress was detected by the measurement...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... and stiffening of the large elastic arteries (i.e., the aorta and carotid arteries), contribute importantly to the age-related increase in CVD risk. Vascular aging is driven in large part by oxidative stress, which reduces bioavailability of nitric oxide and promotes alterations in the extracellular matrix...
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Clin Sci (Lond) (2020) 134 (7): 853–869.
Published: 09 April 2020
...Yun Huang; Yang Li; Anni Lou; Guo zhen Wang; Ye Hu; Yijie Zhang; Weichang Huang; Jun Wang; Yue Li; Xintao Zhu; Tingting Chen; Jiayi Lin; Ying Meng; Xu Li Angiotensin II (Ang II) has been reported to aggravate hepatic fibrosis by inducing NADPH oxidase (NOX)-dependent oxidative stress. Alamandine...
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Clin Sci (Lond) (2020) 134 (4): 403–417.
Published: 25 February 2020
... to diabetic kidney disease. Furthermore, it discusses in detail the underlying mechanisms of adipose inflammation, including pro-inflammatory cytokines, oxidative stress, and AMPK/mTOR signaling pathway and critically describes their role in diabetic kidney disease. This in-depth understanding of adipose...
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Clin Sci (Lond) (2020) 134 (1): 73–74.
Published: 14 January 2020
.... Correspondence: Natalia López-Andrés ( natalia.lopez.andres@navarra.es ) 15 11 2019 23 12 2019 03 01 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 galectins oxidative stress peroxiredoxins Molecular and cellular...
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Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
... function involving the inhibition of oxidative stress-induced injury via sGC-cGMP-PKG pathway and may be a promising therapeutic option for DCM. Table 1 Effects of empagliflozin treatment on cardiac function in db/db mice db/m db/db db/db +Empa Heart rate (beats/min) 585 ± 35 568 ± 49...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (7): 885–904.
Published: 12 April 2019
... and poor diet but the underlying mechanisms have not been fully established. However, there is emerging and compelling experimental and clinical evidence to show that increased oxidative stress causes pulmonary inflammation and that the spill over of pro-inflammatory mediators from the lungs...
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Clin Sci (Lond) (2018) 132 (12): 1257–1280.
Published: 29 June 2018
... that a single measurement provides global assessment of plasma oxidative stress. Rather, assessment of individual thiol pools and thiol-proteins specific to any given condition has more solid and logical perspective to yield novel relevant information on disease risk and prognosis. Correspondence...
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Clin Sci (Lond) (2018) 132 (12): 1297–1314.
Published: 26 June 2018
... oxidative stress are both critical for ensuing diabetic tubular cell injury and apoptosis; whether these two processes are interlinked remains unclear. In the present study, we observed changes in mitochondrial morphology and expression of associated proteins in tubules of patients with DN. We demonstrated...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (8): 869–881.
Published: 30 April 2018
..., intracellular insulin and leptin mediators, and oxidative stress (OS) markers were also measured in islets isolated from each experimental group. HS rats had increased plasma triglyceride, insulin, leptin, and lipid peroxidation (OS marker) levels associated with an insulin-resistant state. Their islets...
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Clin Sci (Lond) (2018) 132 (6): 615–626.
Published: 20 March 2018
... syndromes oxidative stress Kidney stones and CVDs are complex multifactorial results from interactions between environmental and genetic factors [ 1–3 ]. According to National Health and Nutrition Examination Survey (NHANES), the prevalence of history of kidney stones is 10.6% in men and 7.1...
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Clin Sci (Lond) (2017) 131 (23): 2807–2812.
Published: 28 November 2017
... Meal Hyperlipidaemia oxidative stress Oxidative-Nitrosative Stress The consumption of a high-fat meal is characterized by a state of post-prandial hyperlipidaemia (PPH) that can last for as long as 8 h [ 1 ]. During this time course, PPH has been shown to acutely impair systemic vascular...
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Clin Sci (Lond) (2017) 131 (21): 2573–2599.
Published: 25 October 2017
... homeostasis may make older people more susceptible to many diseases. Chronic oxidative stress and defective protein homeostasis (proteostasis) are two major factors associated with the etiology of age-related disorders. In the present paper, we review the contribution of impaired responses to oxidative stress...
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Clin Sci (Lond) (2017) 131 (14): 1689–1700.
Published: 30 June 2017
... provide an effective therapeutic approach to prevent the cardiovascular sequelae associated with excessive adiposity. In this review, we discuss the recent evidence supporting the role of oxidative stress and cytokines and inflammatory signals within the vasculature as well as the impact...
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Clin Sci (Lond) (2017) 131 (14): 1701–1712.
Published: 30 June 2017
... of the disease and may support novel approaches for the management of BPD. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 bronchopulmonary dysplasia hyperoxic stress HO-1 hyperoxic lung injuries Nrf2 Oxidative stress In premature infants...
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