... negatively regulated VSMC proliferation in culture. The possible mechanism may involve serpina3c inhibition of ERK1/2 and JNK signaling in thrombin/PAR-1 system-mediated VSMC proliferation. Our results highlight a protective role for serpina3c as a novel thrombin inhibitor in the development...

...Sarah W.Y. Lok; Wai Han Yiu; Hongyu Li; Rui Xue; Yixin Zou; Bin Li; Kam Wa Chan; Loretta Y.Y. Chan; Joseph C.K. Leung; Kar Neng Lai; Sydney C.W. Tang Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in various organs including kidney. PAR-1 activation leads to deposition...