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Keywords: PCSK9 inhibitors
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Articles

PCSK9 inhibition 2018: riding a new wave of coronary prevention

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Natalie C. Ward, Michael M. Page, Gerald F. Watts
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (2): 205–224.
https://doi.org/10.1042/CS20171300
Published: 22 January 2019
... to lower the risk of cardiovascular disease, PCSK9 inhibitors represent an important therapeutic target, particularly in high-risk populations. Here, we summarise and update the science of PCSK9, including its discovery and the development of various inhibitors, including the now approved monoclonal...
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Articles

Statins, PCSK9 inhibitors and cholesterol homeostasis: a view from within the hepatocyte

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Allan D. Sniderman, Robert Scott Kiss, Thomas Reid, George Thanassoulis, Gerald F. Watts
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (9): 791–797.
https://doi.org/10.1042/CS20160872
Published: 19 April 2017
...Allan D. Sniderman; Robert Scott Kiss; Thomas Reid; George Thanassoulis; Gerald F. Watts Statins and PCSK9 inhibitors dramatically lower plasma LDL levels and dramatically increase LDL receptor number within hepatocyte cell membranes. It seems self-evident that total clearance of LDL particles from...
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