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Takehiro OGATA, Takashi MIYAUCHI, Satoshi SAKAI, Yoko IRUKAYAMA-TOMOBE, Katsutoshi GOTO, Iwao YAMAGUCHI
Journal: Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 284S–288S.
Published: 01 September 2002
... proliferation of fibroblasts and cardiac fibrosis. Peroxisome-proliferator-activated receptor α (PPARα), one of the nuclear hormone receptors, suppresses activator protein-1 (AP-1), one of the nuclear transcription factors. Activation of PPARα is reported to inhibit thrombin-induced ET-1 production by...