... the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . circulating DNA COVID19 Neutrophil pathogenesis Traps While neutrophils are the main starting point for extracellular and circulating DNA release, an effective strategy may be to target NETs rather than neutrophils themselves...

.... The pathogenesis of DKD is twofold, so is the principle of treatments. As the underlying disease, diabetes per se is the root cause of DKD and thus a primary focus of therapy. Meanwhile, aberrant molecular signaling in kidney parenchymal cells and inflammatory cells may directly contribute to DKD. Evidence...

... (an autosomal dominant trait causing TAA appearance in some families), untreated infection (e.g. syphilis, Salmonella ), generic cardiovascular risk factors (e.g. atherosclerosis, smoking, hypertension, increased age, concomitant diseases), are also known to contribute to TAA pathogenesis. autophagy...

... by which genetic variants contribute to COPD and have led to novel insights in COPD pathogenesis. Through functional investigations of causal variants in COPD, from the proteinase–antiproteinase theory to emerging roles of developmental pathways (such as Hedgehog and Wnt pathways) in COPD, we have greatly...

...Richard J. Russell; Christopher Brightling The pathogenesis of asthma is complex and multi-faceted. Asthma patients have a diverse range of underlying dominant disease processes and pathways despite apparent similarities in clinical expression. Here, we present the current understanding of asthma...

.... Personal excess fat is overlooked in less heavy individuals when population metrics are applied to individuals. 8 9 2014 7 10 2014 24 10 2014 © The Authors Journal Compilation © 2015 Biochemical Society 2015 aetiology obesity pathogenesis Type 2 diabetes weight loss...

... Since Alexander Fleming discovered the antibacterial property of penicillin in 1929, large numbers of antibiotics have been developed, making an important contribution to human health in the fight against infectious diseases. Accumulating knowledge on bacterial pathogenesis and antibiotic resistance has...

... ‘membranous webs’ or ‘membrane-associated foci’, whereas viral assembly probably occurs on lipid droplets and endoplasmic reticulum. Liver inflammation plays a central role in the liver damage seen in hepatitis C, but many HCV proteins also directly contribute to HCV pathogenesis. In the present review...

... risk factors for the development and progression of atherosclerosis, which can be identified and modified, may be important therapeutic targets. Infectious agents, such as Chlamydia pneumoniae , have been proposed as contributory factors in the pathogenesis of atherosclerosis. In the present review, we...

... they contribute to specific human diseases. The Biochemical Society 2006 cellular homoeostasis host defence NADPH oxidase pathogenesis phagocyte reactive oxygen species (ROS) superoxide anion As per Human Gene Nomenclature Committee guidelines, all letters of human NOX genes and proteins...

.... The discovery of animal models of T1DM in the late 1970s and early 1980s, particularly the NOD (non-obese diabetic) mouse and the BB (BioBreeding) diabetes-prone rat, had a fundamental impact on our ability to understand the genetics, aetiology and pathogenesis of this disease. NOD and BB diabetes-prone rats...

... neurological syndromes. Correspondence: Dr I. Sutton, Department of Neurology, Room 475, Blackburn Building (D06), University of Sydney, NSW 2006, Australia (e-mail [email protected] ). The Biochemical Society and the Medical Research Society © 2002 2002 paraneoplastic pathogenesis...

... pathogenesis stress vascular reactivity Clinical Science (1982) 63,371s-374s 371s Different haemodynamic reaction patterns during noise exposure in normotensive subjects with and without heredity for essential hypertension L. A N D R B N , S. P I R O S , L. H A N S S O N , H . H E R L I T Z A N D 0. J O N...

...K. Abe; M. Yasujima; N. Irokawa; M. Seino; S. Chiba; Y. Sakurai; M. Sato; Y. Imai; K. Saito; T. Ito; T. Haruyama; Y. Otsuka; K. Yoshinaga To investigate the role of renal vasoactive substances in the pathogenesis of essential hypertension, urinary prostaglandin E excretion, urinary kallikrein...