...Mia Edgerton-Fulton; Yasir Abdul; Sarah Jamil; Adviye Ergul Diabetes mediates endothelial dysfunction and increases the risk of Alzheimer’s disease and related dementias. Diabetes also dysregulates the ET system. ET-1-mediated constriction of brain microvascular pericytes (BMVPCs) has been shown...

... bind to receptors resulting in inflammation and cell, tissue, and organ damage. Avolio et al. previously determined that the S protein acting through the cluster of differentiation 147 (CD147) receptor, and another unknown mechanism had detrimental effects on human cardiac pericytes ( Clin Sci (Lond...

... by pericytes and astrocyte end feet, anatomically assembled to guarantee barrier functions. We, here, focus on the pericyte modifications occurring in disease conditions, reviewing evidence supporting the interplay amongst pericytes, the endothelium, and glial cells in health and pathology. Deconstruction...

... cells PEDF pericytes retinal pigment epithelial cells thrombospondins Age-related macular degeneration (AMD) is a major cause of visual impairment in the elderly population worldwide. In 2010, macular degeneration (mainly age-related) was the third most common cause of blindness (8.69...