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Keywords: Placenta
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Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
... BCAA concentration, placental 14 C-leucine transport activity and associated impacts on fetal growth and development. Poly(I:C) treatment increased acutely maternal IL-6 and TNFα concentration, contrasting with IL-1β. Transcriptional responses for these pro-inflammatory cytokines were found in placenta...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (4): 257–272.
Published: 14 February 2022
... 2022 01 02 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 chemerin chemokine-like receptor 1 placenta preeclampsia soluble Fms-like tyrosine kinase-1 Preeclampsia is a major cause of maternal mortality, yet its...
Includes: Supplementary data
Clin Sci (Lond) (2021) 135 (19): 2307–2327.
Published: 13 October 2021
... are at increased risk for cardiovascular (CV) disease later in life. However, the exact etiology of PE is unknown. Moreover, there are no effective interventions to treat PE or alleviate IUGR and the developmental origins of chronic disease in the offspring. The placenta is critical to fetal growth and development...
Clin Sci (Lond) (2021) 135 (11): 1445–1466.
Published: 11 June 2021
... transporter substrate, was significantly reduced in both fetal sexes in the IF group. Sodium-dependent 14 C-MeAIB uptake into isolated placental plasma membrane vesicles was unchanged. The gene expression of system A transporter Slc38a1, Slc38a2 and Slc38a4 was up-regulated in IF male placentas only...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
.... Placentae were collected at embryonic day 18.5 for histological analysis. Basal heart rate was ∼40 bpm lower in IRAP knockout females compared with wild-type females. The increase in heart rate across gestation was greater in IRAP knockout females than wild-type females. Neither basal nor gestational mean...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (18): 2435–2445.
Published: 25 September 2020
... health issues worldwide. GDM increases the risks of macrosomia, premature infants, and preeclampsia. Although placental dysfunction, including fibrosis is associated with the development of GDM, factors that link these observations remain unknown. Prothymosin α (ProTα) is expressed in the placenta...
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
..., and preeclamptic patients to provide comprehensive insight into genetic components and pathological processes in the placenta contributing to PE. The majority of studies demonstrate miR-210 is upregulated in PE in part driven by HIF-1α and NF-κBp50, stimulated by hypoxia and/or immune-mediated processes. Elevated...
Clin Sci (Lond) (2020) 134 (6): 593–607.
Published: 24 March 2020
... remodeling during early pregnancy. The bioactivity and release of these sEVs differ under differing oxygen tensions and in aberrant pregnancy conditions. Whether the placental cell-derived sEVs released from the hypoxic placenta contribute to the pathophysiology of preeclampsia is not known. We hypothesize...
Includes: Supplementary data
Clin Sci (Lond) (2020) 134 (5): 459–472.
Published: 04 March 2020
... Press and the Biochemical Society under a transformative agreement with CAUL. antiphospholipid antibodies endoplasmic reticulum stress extracellular vesicle placenta preeclampsia Antiphospholipid antibodies are autoantibodies that have been reported to increase a woman’s risk...
Clin Sci (Lond) (2020) 134 (1): 53–70.
Published: 10 January 2020
... epithelium of the human placenta, and decreased expression of amino acid transporter isoforms in the ST plasma membranes is believed to contribute to IUGR. Placental mechanistic target of rapamycin Complex 2 (mTORC2) signaling is inhibited in IUGR and regulates the trafficking of key amino acid transporter...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (12): 1353–1365.
Published: 20 June 2019
... was to determine the effect of VEGFA administration or ARNT overexpression on angiogenic potential of FGRadv ECs. ECs were isolated and cultured from FGRadv or gestational age-matched control placentas and subjected to either vehicle vs VEGFA treatment or transduction with adenoviral-CMV (ad-CMV) vs adenoviral...
Clin Sci (Lond) (2019) 133 (2): 315–319.
Published: 25 January 2019
... cell gestational diabetes miRNA placenta Despite data supportive of a biological plausible link between previously described altered fpEC function in GDM (reviewed in [ 5 ]), the functional significance of variable miRNAs will need to be further investigated more comprehensively. Due...
Clin Sci (Lond) (2018) 132 (2): 295–312.
Published: 25 January 2018
... dams studied on gestational day (G) 19 had reduced circulating T-cell (CD3 + and CD8 + ) populations compared with lean or obese controls. Further, local interleukin (IL) 1β and IL 1 receptor antagonist ( il1rn ) cmRNA were increased in placenta of VSG dams. Placental barrier function was also affected...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (23): 2763–2775.
Published: 23 November 2017
...Vincent Pang; David O. Bates; Lopa Leach The human placenta nourishes and protects the developing foetus whilst influencing maternal physiology for fetal advantage. It expresses several members of the vascular endothelial growth factor (VEGF) family including the pro-angiogenic/pro-permeability...
Clin Sci (Lond) (2016) 130 (11): 931–941.
Published: 29 April 2016
... in the placenta of women with GDM. Placental tissue was collected at term from women with A1GDM (controlled by diet), A2GDM (controlled by medication) and body mass index (BMI)-matched controls (CTRL). miR-143 expression was measured by RT-PCR. Expression of mitochondrial complexes, transcription factors...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (7): 499–512.
Published: 17 February 2016
... and cardiovascular disease later in life. Placental amino acid transfer is critically dependent on the expression of specific transporters in the plasma membrane of the trophoblast, the transporting epithelium of the human placenta. However, the molecular mechanisms regulating this process are largely unknown. Nedd4...
Includes: Supplementary data
Clin Sci (Lond) (2012) 123 (7): 429–435.
Published: 07 June 2012
... and mitochondria. mtDNA may be the trigger of systemic inflammation in pathologies associated with abnormal cell death. PE (pre-eclampsia) is a hypertensive disorder of pregnancy with devastating maternal and fetal consequences. The aetiology of PE is unknown and removal of the placenta is the only effective cure...
Clin Sci (Lond) (2012) 122 (7): 349–359.
Published: 07 December 2011
... tested the hypothesis that maternal stress can affect mTOR signalling at term, and, as a result, influence placental growth. We first investigated the expression of DEPTOR, mTOR, rictor (rapamycin-insensitive companion of mTOR) and raptor (regulatory associated protein of mTOR) from human placentas ( n...
Clin Sci (Lond) (2006) 110 (3): 337–342.
Published: 10 February 2006
... in fetal membranes [Al-Ghafra, Gude, Brennecke and King (2003) Clin. Sci. 105 , 419–423]. Placentas and fetal membranes were collected either at term or pre-term from women either in-labour or not-in-labour, and AdM mRNA abundance was measured in tissue extracts by Northern blot analysis. Increases were...
Clin Sci (Lond) (2005) 108 (1): 81–84.
Published: 15 December 2004
...Danqing CHEN; Minyue DONG; Qin FANG; Jing HE; Zhengping WANG; Xiaofu YANG Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia...
Clin Sci (Lond) (2003) 105 (4): 419–423.
Published: 01 October 2003
...A. AL-GHAFRA; N. M. GUDE; S. P. BRENNECKE; R. G. KING The aim of the present study was to determine the effects of labour and mode of delivery on human placental and fetal membrane content of adrenomedullin (AdM). Placentas and fetal membranes were collected either at term or pre-term gestation...
Clin Sci (Lond) (2003) 104 (4): 437–446.
Published: 21 March 2003
... to the biological reasons underlying the considerable polymorphism in the numbers of repeats in DC-SIGNR, but not DC-SIGN. The expression patterns of both DC-SIGN and DC-SIGNR are discussed in detail, with particular attention to the expression of both molecules in the placenta, which may have implications...
Clin Sci (Lond) (2000) 98 (4): 375–380.
Published: 24 February 2000
...N. M. GUDE; J. L. STEVENSON; E. K. MOSES; R. G. KING Apoptosis (programmed cell death) in the human placenta is likely to play a major role in determining the structure and function of that organ. Fetal growth restriction (FGR) has been shown to be associated with increased levels of placental...
Clin Sci (Lond) (1999) 97 (1): 123–128.
Published: 15 June 1999
...J. L. DI IULIO; N. M. GUDE; R. G. KING; C. G. LI; M.J. RAND; S. P. BRENNECKE Endothelial nitric oxide synthase (NOS) protein and mRNA have been identified and calcium-dependent NOS activity has been measured in human placentae during normal pregnancy. Recently, mRNA and protein for the inducible...
Clin Sci (Lond) (1997) 93 (1): 51–55.
Published: 01 July 1997
...-eclampsia. 2. Placentae were obtained after vaginal delivery or Caesarean section from women who had been assigned to the following groups according to standard obstetric criteria: term non-pre-eclamptic control, term pre-eclamptic, preterm non-pre-eclamptic control and preterm pre-eclamptic. Nitric oxide...
Clin Sci (Lond) (1996) 91 (6): 719–723.
Published: 01 December 1996
.... The aim of the present work was to investigate the molecular mechanism of the reduced enzymic activity in gestational hypertension using as a model Na + ,K + -ATPase purified from human placenta. Na + ,K + -ATPase obtained from term placentas of eight healthy pregnant women and eight age-matched women...
Clin Sci (Lond) (1993) 85 (4): 417–424.
Published: 01 October 1993
... Research Society 1993 endothelin gene expression myometrium placenta pre-eclampsia uterine vein Clinical Science (1993) 85, 417-424 (Printed in Great Britain) Expression of the three endothelin genes and plasma levels of endothelin in preeclamptic and normal gestations L. P. McMAHON, C. W. G...
Clin Sci Mol Med (1978) 55 (4): 329–333.
Published: 01 October 1978
...Jane Horn 1. The placental transfer of urea was studied by perfusing the guinea-pig foetal placenta in situ with dextran solutions containing various amounts of urea, and radioactively labelled urea. 2. Transfer of urea was linearly related to the difference in concentration between the maternal...
Clin Sci Mol Med (1977) 52 (5): 449–456.
Published: 01 May 1977
... of angiotensin II were significantly greater than those in cord arterial blood in babies delivered vaginally but not in those delivered by lower-segment Caesarean section. This suggests the possibility that, during labour, the placenta may contribute to foetal concentrations of angiotensin II. 4. Maternal...
Clin Sci Mol Med (1977) 52 (4): 383–394.
Published: 01 April 1977
...A. H. Balfour; E. A. Jones 1. To investigate the relative degree to which human IgG and other plasma proteins bind to cell membranes of the full-term human placenta, suspensions of membranes mixed with radio-iodinated proteins were incubated at pH 6·5 and subjected to Sepharose 2B column...
Clin Sci Mol Med (1975) 48 (5): 335–440.
Published: 01 May 1975
... transferrin and adult blood transferrin were found to be immunochemically identical. 5. No differences could be detected between the transferrins in their capacities to deliver iron to immature erythrocytes derived from rat bone marrow, which indicates that the rapid transport of iron across the placenta...