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Keywords: Preeclampsia
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Articles
Clin Sci (Lond) (2021) 135 (19): 2307–2327.
Published: 13 October 2021
...Usman M. Ashraf; Dalton L. Hall; Adam Z. Rawls; Barbara T. Alexander Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, is associated with poor fetal growth, intrauterine growth restriction (IUGR) and low birth weight (LBW). Offspring of women who had PE...
Articles
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... 2021 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 heart failure hypertension leptin Obesity preeclampsia Women's Health Both adolescent and adult obesity prevalence has reached proportions of >30% in the United States...
Articles
Clin Sci (Lond) (2021) 135 (9): 1083–1101.
Published: 07 May 2021
...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...
Articles
Clin Sci (Lond) (2020) 134 (17): 2295–2313.
Published: 04 September 2020
...Tamara Sáez; Floor Spaans; Raven Kirschenman; Tatsuya Sawamura; Sandra T. Davidge The lectin-like oxidized low-density-lipoprotein (oxLDL) receptor-1 (LOX-1) has been shown to induce angiotensin II (AngII) type 1 receptor (AT 1 ) activation, contributing to vascular dysfunction. Preeclampsia...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
Articles
Clin Sci (Lond) (2020) 134 (6): 593–607.
Published: 24 March 2020
... remodeling during early pregnancy. The bioactivity and release of these sEVs differ under differing oxygen tensions and in aberrant pregnancy conditions. Whether the placental cell-derived sEVs released from the hypoxic placenta contribute to the pathophysiology of preeclampsia is not known. We hypothesize...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (5): 459–472.
Published: 04 March 2020
...Yunhui Tang; Yan Chen; Yohanes Nursalim; Katie Groom; Anthony Hickey; Larry Chamley; Qi Chen Antiphospholipid autoantibodies (aPLs), a major maternal risk factor for preeclampsia, are taken into the syncytiotrophoblast where they bind intracellular vesicles and mitochondria. Subsequently, large...
Articles
Clin Sci (Lond) (2020) 134 (2): 289–302.
Published: 30 January 2020
...Yanling Chang; Yunyan Chen; Qiong Zhou; Chuan Wang; Lei Chen; Wen Di; Yu Zhang Preeclampsia (PE) is regarded as a pregnancy-associated hypertension disorder that is related to excessive inflammatory responses. Although the gut microbiota (GM) and short-chain fatty acids (SCFAs) have been related...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 87–101.
Published: 21 January 2020
...Kenny Schlosser; Amanpreet Kaur; Natalie Dayan; Duncan J. Stewart; Louise Pilote; Christian Delles Women with a history of preeclampsia (PE) have increased risk of cardiovascular disease (CVD) later in life. However, the molecular determinants underlying this risk remain unclear. We sought...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (12): 1341–1352.
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1215–1242.
Published: 21 June 2018
..., most prominent being marinobufagenin (MBG). A synthetic pathway for MBG has been identified in mammalian placental tissue. Elevated maternal and fetal EDLF, O and MBG have been demonstrated in preeclampsia (PE), and inhibition of red cell membrane sodium, potassium ATPase (Na, K ATPase (NKA)) by EDLF...
Articles
Clin Sci (Lond) (2018) 132 (3): 419–436.
Published: 14 February 2018
...Sabrina M. Scroggins; Donna A. Santillan; Jenna M. Lund; Jeremy A. Sandgren; Lindsay K. Krotz; Wendy S. Hamilton; Eric J. Devor; Heather A. Davis; Gary L. Pierce; Katherine N. Gibson-Corley; Curt D. Sigmund; Justin L. Grobe; Mark K. Santillan The pathogenesis of preeclampsia (PreE), a hypertensive...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (1): 33–36.
Published: 02 January 2018
... preeclampsia Pre-eclampsia, defined as de novo hypertension after 20 weeks’ gestation and albuminuria, maternal organ dysfunction (renal insufficiency, hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome, or neurological complications) and/or fetal growth restriction, is associated...
Articles
Clin Sci (Lond) (2017) 131 (24): 2911–2917.
Published: 08 December 2017
... preeclampsia pregnancy T lymphocytes Pre-eclampsia (PE) is a highly variable and heterogeneous syndrome that is defined by new-onset hypertension after 20 weeks of gestation and one or more of the following diagnostic criteria: new-onset proteinuria, thrombocytopenia, impaired liver function, renal...
Articles
Clin Sci (Lond) (2017) 131 (23): 2753–2762.
Published: 23 November 2017
...Jamil Elfarra; Lorena M. Amaral; Maggie McCalmon; Jeremy D. Scott; Mark W. Cunningham, Jr; Ashley Gnam; Tarek Ibrahim; Babbette LaMarca; Denise C. Cornelius Preeclampsia is associated with hypertension, small-for-gestational-age babies, and increased cytolytic natural killer (NK) cells...
Articles
Clin Sci (Lond) (2017) 131 (23): 2777–2789.
Published: 23 November 2017
... of postpartum women who had preeclampsia (PrEC, n =12) and control women who had a healthy pregnancy (HC, n =12). We hypothesized that (1) PrEC would have a greater vasoconstrictor response to ET-1, and (2) reduced ET B R-mediated dilation. We further hypothesized that ET B R-blockade would attenuate...
Articles
Clin Sci (Lond) (2017) 131 (15): 2047–2058.
Published: 17 July 2017
... pregnancy can lead to organ injury and dysfunction and preeclampsia (PE); however, the molecular mechanisms involved are unknown. We tested the hypothesis that Toll-like receptor (TLR) activation induces major histocompatibility complex (MHC) class II invariant chain peptide (CLIP) expression on immune...
Articles
Clin Sci (Lond) (2017) 131 (13): 1529–1540.
Published: 28 June 2017
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . adipocytes adipokines pregnancy preeclampsia Pre-eclampsia (PE) occurs in 2–4% of all pregnancies and is a leading cause of maternal...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (16): 1417–1434.
Published: 07 July 2016
...Omar C. Logue; Eric M. George; Gene L. Bidwell, III Preeclampsia (PE) is a form of gestational hypertension that complicates ∼5% of pregnancies worldwide. Over 70% of the fatal cases of PE are attributed to cerebral oedema, intracranial haemorrhage and eclampsia. The aetiology of PE originates from...
Articles
Clin Sci (Lond) (2016) 130 (4): 239–246.
Published: 14 January 2016
...Nina D. Paauw; Kim Luijken; Arie Franx; Marianne C. Verhaar; A. Titia Lely Preeclampsia (PE) is a hypertensive pregnancy disorder complicating up to 1–5% of pregnancies, and a major cause of maternal and fetal morbidity and mortality. In recent years, observational studies have consistently shown...
Articles
Clin Sci (Lond) (1985) 69 (4): 477–482.
Published: 01 October 1985
...-eclampsia, 10 normotensive pregnant women and eight normotensive nonpregnant women were determined. 2. In vessels from the women with preeclampsia, the ratio of media thickness to lumen diameter was increased, compared with that in vessels from the other two groups. 3. The vessels from the women...