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Keywords: Pregnancy
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Clin Sci (Lond) (2023) 137 (16): 1311–1332.
Published: 31 August 2023
... sensitivity in both healthy and gestational diabetes mellitus (GDM) pregnancies. The ability of EVs to transfer molecular cargo between cells imbues them with potential as therapeutic agents. During pregnancy, the placenta assumes a vital role in metabolic regulation, with multiple mechanisms of placenta...
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Clin Sci (Lond) (2023) 137 (5): 385–399.
Published: 15 March 2023
...Matthew Kang; Cherie Blenkiron; Lawrence W. Chamley Human pregnancy is a highly orchestrated process requiring extensive cross-talk between the mother and the fetus. Extracellular vesicles released by the fetal tissue, particularly the placenta, are recognized as important mediators of this process...
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Clin Sci (Lond) (2023) 137 (1): 31–34.
Published: 03 January 2023
... Placenta pregnancy The importance of studying placental lipid metabolism cannot be overemphasized because it not only influences pregnancy outcomes but also fetal growth, development, and life-long health [ 1 ]. A growing body of evidence demonstrates that the assumption of free diffusion of maternal...
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Clin Sci (Lond) (2022) 136 (22): 1591–1614.
Published: 14 November 2022
... degradation detrimental to tissue homeostasis. Correspondence: Ramkumar Menon ( ra2menon@utmb.edu ) 25 07 2022 14 10 2022 17 10 2022 17 10 2022 EMT pregnancy Senescence Reactive oxygen species (ROS) generated in response to both endogenous and exogenous stimuli...
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Clin Sci (Lond) (2022) 1117–1137.
Published: 05 August 2022
...Hager M. Kowash; Harry G. Potter; Rebecca M. Woods; Nick Ashton; Reinmar Hager; Joanna C. Neill; Jocelyn D. Glazier Maternal infection during pregnancy increases the offspring risk of developing a variety of neurodevelopmental disorders (NDDs), including schizophrenia. While the mechanisms remain...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
...Nayara Azinheira Nobrega Cruz; Danielle Stoll; Dulce Elena Casarini; Mariane Bertagnolli In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme...
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Clin Sci (Lond) (2021) 135 (9): 1083–1101.
Published: 07 May 2021
...Anna E. Stanhewicz; Virginia R. Nuckols; Gary L. Pierce Preeclampsia is a hypertensive disorder of pregnancy effecting ∼5–8% of pregnancies in the United States, and ∼8 million pregnancies worldwide. Preeclampsia is clinically diagnosed after the 20 th week of gestation and is characterized by new...
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Clin Sci (Lond) (2020) 134 (23): 3123–3136.
Published: 07 December 2020
... of trophoblast serotonin synthesis and OGT protein expression. Sex of placental samples collected from first and second trimester pregnancies was determined by PCR detection of sex-determining region Y (SRY) transcripts from extracted genomic DNA. Briefly, DNA was extracted from frozen placental homogenate...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
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Clin Sci (Lond) (2019) 133 (23): 2379–2400.
Published: 04 December 2019
...-containing protein (Brd) 2 (Brd2), Brd3 and Brd4 regulate inflammation in non-gestational tissues. The roles of Brd2–4 in human pregnancy are unknown. Using human and mouse models, the present study has identified the Brd proteins part of the process by which inflammation induces parturition. Using human...
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Clin Sci (Lond) (2019) 133 (12): 1341–1352.
Published: 20 June 2019
...Emilie Hitzerd; Rugina I. Neuman; Katrina M. Mirabito Colafella; Irwin K.M. Reiss; Anton H. van den Meiracker; A.H. Jan Danser; Willy Visser; Jorie Versmissen; Langeza Saleh Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate...
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Clin Sci (Lond) (2018) 132 (2): 295–312.
Published: 25 January 2018
...-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal...
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Clin Sci (Lond) (2017) 131 (24): 2911–2917.
Published: 08 December 2017
...Erin B. Taylor; Jennifer M. Sasser Although pre-eclampsia (PE), a hypertensive disorder of pregnancy, has significant maternal and fetal morbidity and mortality worldwide, the mechanisms contributing to this disease have not been fully elucidated. Studies in patients and experimental models have...
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Clin Sci (Lond) (2017) 131 (23): 2795–2805.
Published: 28 November 2017
...Katrina M. Mirabito Colafella; Chrishan S. Samuel; Kate M. Denton Relaxin is increasingly being recognized as a potent vasodilatory and antifibrotic hormone. Given that relaxin is present in the circulation during the luteal phase of the menstrual cycle and during pregnancy, when arterial pressure...
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Clin Sci (Lond) (2017) 131 (23): 2753–2762.
Published: 23 November 2017
... 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Hypertension Intrauterine growth restriction Inflammation Natural Killer Cells Pregnancy Preeclampsia Preeclampsia (PE) is a pregnancy specific multisystem hypertensive disorder...
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Clin Sci (Lond) (2017) 131 (17): 2223–2240.
Published: 10 August 2017
...Rachel J. Skow; Emily C. King; Craig D. Steinback; Margie H. Davenport During healthy pregnancy, the cardiovascular system undergoes diverse adaptations to support adequate transfer of oxygen and nutrients from mother to fetus. In order to accommodate the large expansion of blood volume...
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Clin Sci (Lond) (2016) 130 (9): 651–665.
Published: 18 March 2016
...Michèle Bisson; Isabelle Marc; Patrice Brassard Cerebral blood flow (CBF) regulation is an indicator of cerebrovascular health increasingly recognized as being influenced by physical activity. Although regular exercise is recommended during healthy pregnancy, the effects of exercise on CBF...
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Clin Sci (Lond) (2016) 130 (7): 491–497.
Published: 17 February 2016
...Wan N. Wan Sulaiman; Muriel J. Caslake; Christian Delles; Helen Karlsson; Monique T. Mulder; Delyth Graham; Dilys J. Freeman The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated...
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Clin Sci (Lond) (2016) 130 (6): 409–419.
Published: 04 February 2016
...Ashlyn C. Harmon; Denise C. Cornelius; Lorena M. Amaral; Jessica L. Faulkner; Mark W. Cunningham, Jr; Kedra Wallace; Babbette LaMarca Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated...
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Clin Sci (Lond) (2015) 129 (12): 1131–1141.
Published: 22 October 2015
... from women with pregnancies complicated by IUGR ( n =25) and gestational age-matched women with appropriately grown control infants ( n =19, birth weights between the twenty-fifth to seventy-fifth percentiles). The activity of mTORC1 and mTORC2 was decreased whereas the protein expression...
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Clin Sci (Lond) (2013) 124 (1): 27–40.
Published: 07 September 2012
...Pengfei Li; Wei Guo; Leilei Du; Junli Zhao; Yaping Wang; Liu Liu; Yali Hu; Yayi Hou PE (pre-eclampsia), a pregnancy-specific disorder, is characterized by increased trophoblast cell death and deficient trophoblast invasion and reduced trophoblast-mediated remodelling of spiral arteries. The present...
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Clin Sci (Lond) (2012) 123 (7): 429–435.
Published: 07 June 2012
... and mitochondria. mtDNA may be the trigger of systemic inflammation in pathologies associated with abnormal cell death. PE (pre-eclampsia) is a hypertensive disorder of pregnancy with devastating maternal and fetal consequences. The aetiology of PE is unknown and removal of the placenta is the only effective cure...
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Clin Sci (Lond) (2012) 123 (2): 53–72.
Published: 23 March 2012
...Esther F. Davis; Laura Newton; Adam J. Lewandowski; Merzaka Lazdam; Brenda A. Kelly; Theodosios Kyriakou; Paul Leeson Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk...
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Clin Sci (Lond) (2011) 121 (8): 355–365.
Published: 24 June 2011
...Tracey L. Weissgerber; Gregory A. L. Davies; Michael E. Tschakovsky Whether brachial artery FMD (flow-mediated dilation) is altered in pregnancy by 28–35 weeks compared with non-pregnant women remains controversial. The controversy may be due to limitations of previous studies that include failing...
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Clin Sci (Lond) (2009) 116 (7): 599–606.
Published: 02 March 2009
...Dominica Zentner; Moira du Plessis; Shaun Brennecke; James Wong; Leeanne Grigg; Stephen B. Harrap The aim of the present study was to undertake a longitudinal study of systolic and diastolic cardiac function during normal pregnancy. At a median of 16 weeks of gestation, 100 primiparous women...
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Clin Sci (Lond) (2007) 113 (1): 1–13.
Published: 01 June 2007
... the placenta in order to affect the fetus. Here, we review recent insights into how the placenta responds to changes in the maternal environment and discuss possible mechanisms by which the placenta mediates fetal programming. In IUGR (intrauterine growth restriction) pregnancies, the increased placental...
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Clin Sci (Lond) (2006) 110 (5): 605–609.
Published: 11 April 2006
... are limited. To evaluate the role of visfatin in GDM (gestational diabetes mellitus), we determined visfatin levels in women with GDM and in healthy pregnant controls. Furthermore, visfatin concentrations were investigated longitudinally during pregnancy and after delivery in a subgroup of women with GDM...
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Clin Sci (Lond) (2006) 110 (4): 443–458.
Published: 15 March 2006
... 2006 16 1 2006 The Biochemical Society 2006 Figure 1 Suggested pathophysiological mechanisms in pre-eclampsia fetal genotype genome-wide screen hypertension maternal genotype pre-eclampsia pregnancy susceptibility gene Pre-eclampsia is a potentially life...
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Clin Sci (Lond) (2006) 110 (3): 337–342.
Published: 10 February 2006
... that the intensity of AdM expression in the amniotic membranes in the first trimester of pregnancy is similar to that in term pregnancy, suggesting that amniotic membranes may be a site of production or binding of AdM during pregnancy [ 6 ]. Also, the importance of AdM in placental and fetal growth and development...
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Clin Sci (Lond) (2005) 109 (1): 103–107.
Published: 23 June 2005
...Beatrix MERSICH; János RIGÓ, Jr; Csilla BESENYEI; Zsuzsanna LÉNÁRD; Péter STUDINGER; Márk KOLLAI Systemic arterial compliance has been known to increase during healthy pregnancy, whereas, recently, the carotid artery has been reported to stiffen. To clarify this controversy, we simultaneously...
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Clin Sci (Lond) (2005) 108 (1): 81–84.
Published: 15 December 2004
...Danqing CHEN; Minyue DONG; Qin FANG; Jing HE; Zhengping WANG; Xiaofu YANG Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia...