... that physiological atrial enlargement resulted from increased atrial myocyte size and was associated with preserved atrial function, as determined by maintained LA ejection fraction (EF). The proteomic profile of IGF1R transgenic (Tg) mice was enriched for metabolic remodeling and showed a protein expression pattern...

... cancer patients. α-Adrenergic-antagonists were identified as drugs that most oppose the VEGFRi proteomic signature. Doxazosin, one such α-antagonist, prevented EC dysfunction in murine, canine, and human aortic ECs. In mice with sorafenib-induced-hypertension, doxazosin mitigated EC dysfunction...

... failure gene expression pattern. Atrial proteomics identified protein networks related to cardiac contractility, sarcomere assembly, metabolism, mitochondria, and extracellular matrix which were differentially regulated in the models; many co-identified in atrial proteomics data sets from human AF...

...-converting enzyme inhibitor (ramipril), or a combination of both drugs for 8 weeks to diabetic (db/db) mice. Vehicle-treated db/db and db/m mice were used as controls. At the end of the experiment, mice were killed, and the kidneys were saved to perform a differential high-throughput proteomic analysis...

... was explored. Indeed, the activation of EGFR was seen upon incubation with β2M and the profibrotic response of β2M was abolished upon silencing or inhibition of EGFR. epidermal growth factor receptor fibrosis paracrine signalling proteomics Hypertension is a well-known contributor...

... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...

... diet (by addition of nonessential amino acid) ( Ctrl ) and trained (running on treadmill 5 days·week −1 ) ( ex ) or not. Maximal endurance activity and body composition were assessed, and muscle protein metabolism (protein synthesis, proteomic approach) and energy metabolism [energy expenditure...

... from four AAA patients and four controls were analysed by a label-free proteomic approach. Among identified proteins, paraoxonase-1 (PON1) was decreased in plasma of AAA patients compared with controls, which was further validated in a bigger cohort of samples by ELISA. The phenylesterase enzymatic...

... mechanism and causal risk factors for plaque rupture remain unclear. To identify a potential molecule that can influence atherosclerotic plaque rupture, we investigated protein expression in serum from patients with acute myocardial infarction (AMI) and stable angina (SA), using proteomic analysis...

...). However, the precise pathophysiological mechanisms underlying acute coronary occlusion are not fully understood. We have analysed proteomic profiles of systemic plasma and plasma derived from the site of coronary plaque rupture of non-diabetic patients with STEMI (ST-segment elevation myocardial...

... and high mortality rate. Its pathophysiology and molecular mechanisms are complicated and remain poorly understood. In the present study, we performed a proteomics investigation to characterize early host responses to sepsis as determined by an altered plasma proteome in a porcine model of peritonitis...

... significantly higher in the two T2DM groups. M/I and adiponectin levels were significantly lower in subjects with T2DM compared with controls with NGT. Cystatin-based GFR was significantly higher in subjects with T2DM+low EIR ( Table 1 ). early insulin response plasma protein proteomics surface-enhanced...

...Laura Molero; Antonio García-Méndez; Sergio Alonso-Orgaz; Carolina Carrasco; Carlos Macaya; Antonio J. López Farré The aim of the present study was to use proteomics to analyse modifications in the level of expression of different proteins in BVSMCs (bovine vascular smooth muscle cells) incubated...

...Bernardo C. Vidal, Jr; Joseph V. Bonventre; Stephen I-Hong Hsu Proteomics is widely envisioned as playing a significant role in the translation of genomics to clinically useful applications, especially in the areas of diagnostics and prognostics. In the diagnosis and treatment of kidney disease...

...Walter KOLCH; Harald MISCHAK; Andrew R. PITT The enormous progress in proteomics, enabled by recent advances in MS (mass spectrometry), has brought protein analysis back into the limelight of cancer research, reviving old areas as well as opening new fields of study. In this review, we discuss...

... or isotopic (with in vivo radioactive labelling of proteins) two-dimensional electrophoresis/MS proteomic analyses, to study differential expression of proteins. Many of the differentially expressed proteins identified in blood were specifically synthesized by the liver to participate in the stress response...

... indicative of ‘diabetic renal damage’. We also found this pattern in 35% of those patients who had low-grade albuminuria and in 4% of patients with normal albumin excretion. Moreover, we could identify several of the indicative polypeptides using MS/MS sequencing. We conclude that proteomic analysis with CE...

...Pedro R. CUTILLAS; Anthony G.W. NORDEN; Rainer CRAMER; Alma L. BURLINGAME; Robert J. UNWIN Urinary proteomics has become a topical and potentially valuable field of study in relation to normal and abnormal renal function. Filtered bioactive peptides present in high concentration in the nephron...