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Keywords: Regeneration
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Clin Sci (Lond) (2022) 136 (12): 911–934.
Published: 20 June 2022
... therapeutically targets that could guide future clinical studies toward cardiac repair. Our review gives a summary of the current understanding of the regulation of CM proliferation during development and regeneration. Very little is about known how human CM mature and proliferate. The available evidence...
Clin Sci (Lond) (2022) 136 (10): 787–798.
Published: 27 May 2022
... cardiac regeneration to replenish lost or damaged myocardial tissue. Long-term high-resolution intravital imaging of the behaviors and interactions of different cardiac cell types in their native environment could yield unprecedented insights into heart regeneration and repair. However, this task remains...
Clin Sci (Lond) (2017) 131 (24): 2919–2932.
Published: 08 December 2017
...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...
Includes: Supplementary data
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...
Clin Sci (Lond) (2015) 129 (12): 1173–1193.
Published: 11 November 2015
... and autoimmune diseases. The HGF/Met axis also plays an important role in regulating self-renewal and myocardial regeneration through the enhancement of cardiac progenitor cells. HGF/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellular and molecular mechanisms...
Clin Sci (Lond) (2015) 128 (2): 81–93.
Published: 05 September 2014
..., and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support...
Clin Sci (Lond) (2013) 125 (7): 319–327.
Published: 07 June 2013
... very little ability to make new cardiomyocytes, stem-cell-based cardiac regeneration has attracted a great deal of interest to repair failing hearts resulting from acute MI (myocardial infarction), chronic ischaemia or idiopathic cardiomyopathy [ 3 ]. These stem cells have been delivered in diseased...
Clin Sci (Lond) (2010) 118 (12): 691–705.
Published: 30 March 2010
... κB (NF-κB) regeneration NF-κB (nuclear factor κB) was first described in 1986 as a nuclear transcription factor required for immunoglobulin kappa light chain transcription in B-cells [ 1 ]. Since then it has been demonstrated that NF-κB is constitutively expressed in all cell types and holds...
Clin Sci (Lond) (2005) 108 (4): 309–321.
Published: 22 March 2005
... of transdifferentiation, describe the theoretical and practical issues involved in transdifferentiation research and comment on the long-term therapeutic possibilities. The ability to regenerate cells and tissues is possessed by all organisms. However, regenerative capacity varies considerably between species...
Clin Sci (Lond) (1995) 89 (4): 447–452.
Published: 01 October 1995
... contraction mdx myofibre type necrosis regeneration Clinical Science (1995) 89, 447-452 (printed in Great Britain) Effects of treadmill exercise and high-fat feeding on muscle degeneration in mdx mice at the time of weaning Asghar MOKHTARIANI, Jean Pascal LEFAUCHEUR2, Patrick C. EVEN' and Alain SEBILLP...