...Adam C. Jones; Oleg Palygin; Daria V. Ilatovskaya The commentary discusses the regenerative capacity of the kidneys; recent studies reveal that renal cells can regenerate when exposed to certain conditions. A major focus is on scattered tubular-like cells (STCs), which can dedifferentiate...

... fostering effective cardiac regeneration are the holy grail of cardiovascular research to stop the heart failure epidemic. The main goal of most myocardial regeneration protocols is the generation of new functional CMs through the differentiation of endogenous or exogenous cardiomyogenic cells...

... [ 4 ]. Intriguingly, myocardial repair based in CM proliferation has been observed in neonatal mice subjected to apical resection [ 5 ]. Therefore, the proliferative capacity of CM observed in vertebrate model organisms suggests that the adult mammalian heart could potentially regenerate itself when...

... cardiac regeneration to replenish lost or damaged myocardial tissue. Long-term high-resolution intravital imaging of the behaviors and interactions of different cardiac cell types in their native environment could yield unprecedented insights into heart regeneration and repair. However, this task remains...

...Dezhong Yang; Wenbin Fu; Liangpeng Li; Xuewei Xia; Qiao Liao; Rongchuan Yue; Hongmei Chen; Xiongwen Chen; Songzhu An; Chunyu Zeng; Wei Eric Wang After myocardial infarction (MI), the heart is difficult to repair because of great loss of cardiomyoctyes and lack of cardiac regeneration. Novel drug...

..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...

... and autoimmune diseases. The HGF/Met axis also plays an important role in regulating self-renewal and myocardial regeneration through the enhancement of cardiac progenitor cells. HGF/Met has beneficial effects against myocardial infarction and endothelial dysfunction: the cellular and molecular mechanisms...

..., and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support...

... transplantation. The mammalian adult heart undergoes some endogenous regeneration, as evidenced by the appearance of a large number of new cardiomyocytes after injury and cardiomyocyte turnover during a normal life span [ 36 ]. The self-renewal of adult myocardium may result from proliferation...

... hepatocellular carcinoma ischaemia/reperfusion injury non-alcoholic fatty liver disease (NAFLD) nuclear factor κB (NF-κB) regeneration NF-κB (nuclear factor κB) was first described in 1986 as a nuclear transcription factor required for immunoglobulin kappa light chain transcription in B-cells [ 1...

... of transdifferentiation, describe the theoretical and practical issues involved in transdifferentiation research and comment on the long-term therapeutic possibilities. Figure 1 Transdifferentiation of PECs to lens fibres during lens regeneration PECs of the dorsal iris undergo depigmentation and re-entry...

... contraction mdx myofibre type necrosis regeneration Clinical Science (1995) 89, 447-452 (printed in Great Britain) Effects of treadmill exercise and high-fat feeding on muscle degeneration in mdx mice at the time of weaning Asghar MOKHTARIANI, Jean Pascal LEFAUCHEUR2, Patrick C. EVEN' and Alain SEBILLP...

..., at least in part, to accelerated tubular cell proliferation. 5 12 1989 20 12 1989 © 1990 The Biochemical Society and the Medical Research Society 1990 creatinine epidermal growth factor epidermal growth factor receptor necrosis regeneration Clinical Science (1990) 78,445-450...