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Keywords: Renin-Angiotensin System
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Clin Sci (Lond) (2023) 137 (15): 1145–1150.
Published: 09 August 2023
... Notch signaling, the reninangiotensin system, and renal cystic disease [ 2 ]. We thank Dr. Alan Yu for providing his expert comments on this commentary. This work is supported by a grant from the Polycystic Kidney Disease Foundation, pkdcure.org to M.S. The Foundation had no role in study design...
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Clin Sci (Lond) (2023) 137 (1): 35–45.
Published: 05 January 2023
.... Correspondence: Brian C. Belyea ( [email protected] ) 27 07 2022 06 12 2022 08 12 2022 12 12 2022 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 notch signalling pathway renal physiology renin-angiotensin system...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (10): 799–802.
Published: 27 May 2022
... the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge. In 2011, Robert Widdop’s group from Monash University, Australia, with Sanja...
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Clin Sci (Lond) (2021) 135 (23): 2619–2623.
Published: 08 December 2021
... Limited on behalf of the Biochemical Society 2021 Angiotensin-(1-7) Cardiovascular System Renin-Angiotensin System Sympathetic Nervous System Transgenic Rat Vasopressin The reninangiotensin system (RAS) regulates hydromineral balance, cardiovascular, renal, neuronal, and other organ...
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Clin Sci (Lond) (2021) 135 (17): 2035–2048.
Published: 31 August 2021
... renal injury, hydralazine (Sigma–Aldrich) was administrated at the dose 250 mg/l/day in the drinking water for 14 days as described in previous report [ 13 ]. chronic kidney disease inflammation interleukin-1 renin-angiotensin system Hypertension (HT) is one of the most important cause...
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Clin Sci (Lond) (2021) 135 (7): 911–924.
Published: 12 April 2021
...-angiotensin system Cardiovascular diseases represent a worldwide cause of death. Uncontrolled hypertension or high blood pressure (BP) increases the risk of cardiac dysfunction, stroke and renal diseases [ 1 , 2 ]. The development and progression of hypertension is very complex and involves...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
...Xi Cao; Li-Ni Song; Jin-Kui Yang The reninangiotensin system (RAS) has currently attracted increasing attention due to its potential function in regulating energy homeostasis, other than the actions on cellular growth, blood pressure, fluid, and electrolyte balance. The existence of RAS is well...
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Clin Sci (Lond) (2020) 134 (23): 3213–3228.
Published: 11 December 2020
... physiology renin-angiotensin system Pregnancy initiates a cascade of profound cardiovascular and renal adaptations, ultimately leading to a rise in cardiac output to ensure adequate oxygen and nutrient supply to the developing fetus [ 1 , 2 ]. Many of these adaptations are mediated by the renin...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
...Fiona J. Warner; Harinda Rajapaksha; Nicholas Shackel; Chandana B. Herath Twenty years ago, the discovery of angiotensin-converting enzyme 2 (ACE2) was an important breakthrough dramatically enhancing our understanding of the reninangiotensin system (RAS). The classical RAS is driven by its key...
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Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... and characterization, studies on ACE2 have revealed a previously hidden face of the reninangiotensin system (RAS), the so called ACE2–Ang-(1–7) axis, with many physiologic, pathologic and therapeutic implications [ 11–25 ]. Indeed, the best known enzymatic function of ACE2 is the cleavage of Angiotensin II (1–8...
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Clin Sci (Lond) (2020) 134 (19): 2581–2595.
Published: 14 October 2020
...Qiuhong Li; Maria B. Grant; Elaine M. Richards; Mohan K. Raizada The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the reninangiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance...
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Clin Sci (Lond) (2020) 134 (19): 2535–2547.
Published: 05 October 2020
...Mazher Mohammed; Clara Berdasco; Eric Lazartigues The brain reninangiotensin system (RAS) plays an important role in the regulation of autonomic and neuroendocrine functions, and maintains cardiovascular homeostasis. Ang-II is the major effector molecule of RAS and exerts most of its physiological...
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Clin Sci (Lond) (2020) 134 (18): 2489–2501.
Published: 29 September 2020
...-7) thereby counterbalancing the action of ACE on the reninangiotensin system (RAS) and providing a cardioprotective role. Unlike ACE, ACE2 does not metabolise bradykinin nor is it inhibited by classical ACE inhibitors. However, it does convert a number of other regulatory peptides in vitro...
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Clin Sci (Lond) (2020) 134 (17): 2319–2336.
Published: 09 September 2020
... (CV) system. The apelin pathway’s dominant physiological role has delineated therapeutic implications for coronary artery disease, heart failure (HF), aortic aneurysm, pulmonary arterial hypertension (PAH), and transplant vasculopathy. Apelin peptides interact with the reninangiotensin system (RAS...
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Clin Sci (Lond) (2020) 134 (13): 1763–1774.
Published: 10 July 2020
.... Correspondence: R. Ariel Gomez ( [email protected] ) 03 03 2020 23 06 2020 03 07 2020 03 07 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 Ctcf homeostasis hypertension nephrology renin-angiotensin system vasculature...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (4): 379–388.
Published: 17 February 2020
... on behalf of the Biochemical Society 2020 chronic kidney disease renal glomerulus renin-angiotensin system Figure 1 Physiology of glomerular filtration and glucose handling in the proximal tubule In the kidney, filtered glucose via the glomerular basement membrane enters the lumen...
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Clin Sci (Lond) (2019) 133 (17): 1883–1899.
Published: 10 September 2019
... transporter 4 (Glut4) trafficking. Dietary salt in HF fed rats also increased the activity of the adipose-cerebral-muscle reninangiotensin system (RAS) axes, SNS, and reactive oxygen species (ROS). Insulin sensitivity was reduced by 32% in HF rats during high-salt intake, but was improved by over 62...
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Clin Sci (Lond) (2019) 133 (1): 75–82.
Published: 08 January 2019
... a key role in blood pressure control by tightly regulating the net balance of salt in the body [ 1 ]. aldosterone intercalated cells renin-angiotensin system renal physiology Figure 1 Mechanism of ENaC regulation by aldosterone Abbreviation: Aldo, aldosterone. In cortical...
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Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
... disease endothelial dysfunction microparticles renin-angiotensin system sodium intake type 2 diabetes Cardiovascular-related disease is the leading cause of morbidity and mortality in people with diabetes [ 1 ]. Reduction in blood pressure lowers cardiovascular risk [ 2 ]. As high dietary...
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Clin Sci (Lond) (2018) 132 (2): 285–294.
Published: 25 January 2018
... studied relationships between salt intake, BP and reninangiotensin system regulation in order to establish if it is disordered in CKD. Methods: Mechanistic crossover study of CKD patients versus non-CKD controls. Participants underwent modified saline suppression test prior to randomization to either low...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (11): 1093–1105.
Published: 17 May 2017
... of trophic factors and of reninangiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease. In this review, we discuss experimental and clinical evidence for the role of these mechanisms in kidney–brain cross-talk. In addition, we hypothesize...
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Clin Sci (Lond) (2016) 130 (13): 1075–1088.
Published: 23 May 2016
... (reninangiotensin system) may contribute to this. This study relied on an established angiotensin, AngII (angiotensin II)-elevated dTGR (double-transgenic rat) model and same-background SD (Sprague–Dawley) rat controls. In dTGRs, plasma levels of AngII were increased. We determined the general retinal...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (7): 525–538.
Published: 17 February 2016
... of the reninangiotensin system, is a clinical problem present in a small number of patients with chronic kidney disease (CKD). The mechanism underlying this resistant albuminuria remains unknown. Matrix metalloproteinases (MMPs) are involved in the pathophysiology of cardiovascular and renal diseases...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (6): 461–476.
Published: 22 June 2015
.... angiotensin-(1–7) lipopolysaccharide Mas receptor reninangiotensin system sepsis syndrome skeletal muscle atrophy • During sepsis syndrome induced by endotoxaemia, loss of strength and muscle mass occur, resulting in a pathological condition called skeletal muscle atrophy. The RAS (renin...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (11): 749–750.
Published: 17 March 2015
...Anton J.M. Roks Optimization of stem cell therapy after cardiovascular and renal injury depends on many factors, among which is stem cell donor health. The reninangiotensin system (RAS) plays an important role in cardiovascular and renal homoeostasis and pathophysiology. It is becoming...
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Clin Sci (Lond) (2014) 127 (9): 549–557.
Published: 03 July 2014
...Maria Paz Ocaranza; Luis Michea; Mario Chiong; Carlos F. Lagos; Sergio Lavandero; Jorge E. Jalil Chronic RAS (reninangiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic...
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Clin Sci (Lond) (2014) 126 (7): 507–516.
Published: 11 December 2013
...) AMP-activated protein kinase (AMPK) angiotensin-(1–7) reninangiotensin system SIRT1 • Recent work has provided evidence that enhancing ACE2 levels is able to reverse cardiac and renal pathologies in vivo and, in particular, may be a viable therapeutic option for ARDS...
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Clin Sci (Lond) (2014) 126 (1): 31–39.
Published: 30 August 2013
... in relation to our understanding of the underlying mechanisms involved in septic shock, and highlight the attempts made to improve animal experimental models. We also review recent studies reporting promising results with two vastly different therapeutic approaches influencing the reninangiotensin system...
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Clin Sci (Lond) (2013) 125 (7): 311–318.
Published: 07 June 2013
.... In addition, the fact that renal denervation failed to reduce the blood pressure to normotensive levels suggests that there are other mechanisms responsible for the hypertension in male and female SHRs. Other mechanisms include the RAS (reninangiotensin system). We found that blockade of the RAS...
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Clin Sci (Lond) (2013) 124 (2): 87–96.
Published: 26 September 2012
... (AT 2 receptor) B 1 kinin receptor B 2 kinin receptor heart failure inflammation myocardial infarction reninangiotensin system • CVD is the leading cause of death in the U.S.A. and worldwide. Activation of the RAS plays a crucial role in the pathophysiology of CVD and up until now...
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Clin Sci (Lond) (2012) 123 (10): 567–590.
Published: 23 July 2012
... 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiotensin II type 1 receptor blocker (ARB) brain inflammation neuronal injury reninangiotensin system ARBs {AT 1 [AngII (angiotensin II) type 1] receptor blockers} have significant potential...