... hyperammonaemia (>0.1 mmol-1.49 mmol/l in Reye's syndrome patients) may be one of the causes of fatty acidaemia. 5. The cumulative inhibitory effects of NH + 4 and fatty acyl derivatives on mitochondrial oxidative metabolism and production of ATP, as well as the uncoupling effects of salicylate, may contribute...

...Ellen S. Kang; Mary T. Capaci; David N. Korones; Nilima Tekade 1. The concentrations of the acid soluble and insoluble coenzyme A (CoA) esters were measured in samples of liver obtained at autopsy from Reye's syndrome and control subjects because the long chain fatty CoA compounds which make up...