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1-19 of 19
Keywords: SARS-CoV-2
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Articles
Madhuri Salker, Anna Liu, Natalia Ruetalo, Janet Pushpa Raja Xavier, Aditya Kumar Lankapalli, Jakob Admard, Miguel Camarena-Sainz, Sara Brucker, Yogesh Singh, Michael Schindler
Journal:
Clinical Science
Clin Sci (Lond) (2024) CS20241215.
Published: 12 December 2024
...Madhuri Salker; Anna Liu; Natalia Ruetalo; Janet Pushpa Raja Xavier; Aditya Kumar Lankapalli; Jakob Admard; Miguel Camarena-Sainz; Sara Brucker; Yogesh Singh; Michael Schindler Vertical transmission of SARS-CoV-2 during human pregnancy remains highly controversial as most studies have focused...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (8): 633–643.
Published: 21 April 2023
... , in vitro , and in vivo for cannabidiol (CBD), Δ 9 -tetrahydrocannabinol (Δ 9 -THC), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), and several other cannabinoids against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus (HIV), and γ-herpes viruses...
Articles
Ildernandes Vieira-Alves, Antonielle Rodrigues Pereira Alves, Natália Muradas Valério Souza, Tales Leonardo de Melo, Leda Maria de Castro Coimbra Campos, Larisse de Souza Barbosa Lacerda, Celso Martins Queiroz-Junior, Ana Cláudia dos Santos Pereira Andrade, Luciola Silva Barcelos, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Steyner F. Cortes, Virginia S. Lemos
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (7): 543–559.
Published: 13 April 2023
...-CoV-2. Wild-type C57BL/6 (WT) and knockout mice for inducible nitric oxide synthase (iNOS −/− ) or TNF receptor 1 (TNFR1 −/− ) were infected with MHV-3, and K18-hACE2 transgenic mice expressing human ACE2 were infected with SARS-CoV-2. Isometric tension was used to evaluate vascular function. Protein...
Includes: Supplementary data
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (21): 1571–1590.
Published: 11 November 2022
... are caused by SARS-CoV-2 infection of ECs through the angiotensin-converting enzyme 2 (ACE2) receptor and the cellular transmembrane protease serine 2 (TMPRSS2) and the consequent dysfunction of the infected vascular cells. Meanwhile, other factors associated with SARS-CoV-2 entry into the host cells have...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (13): 1047–1052.
Published: 06 July 2022
...Erin B. Taylor Dysregulation of neutrophil extracellular trap (NET) formation has been shown to mediate disease pathology in multiple viral infections, including SARS-CoV-2. At the beginning of COVID-19 pandemic, Thierry and Roch wrote a perspective on the mechanisms by which severe SARS-CoV-2...
Articles
In Collection
Coronavirus
Martin Sebastian Winkler, Ralf Alexander Claus, Mareike Schilder, Stefan Pöhlmann, Sina M. Coldewey, Julian Grundmann, Torben Fricke, Onnen Moerer, Konrad Meissner, Michael Bauer, Heike Hofmann-Winkler, Markus H. Gräler
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (24): 2781–2791.
Published: 22 December 2021
... oxygenation. We hypothesize that sphingosine 1-phosphate (S1P), a lipid signaling molecule stored and released by RBCs, may play a crucial role in the adaptation to SARS-CoV-2-induced hypoxemia, lung failure and inadequate host response for three reasons: (i) increased S1P level in RBC supports...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (19): 2217–2242.
Published: 08 October 2021
... interplay between DC subsets and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Despite being initiated by a vast array of immune receptors, DC-mediated antiviral responses often converge towards the same endpoint, that is the production of proinflammatory cytokines and the activation...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1805–1824.
Published: 02 August 2021
... (ACE) 2 (ACE2), the main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable for viral infection during pregnancy. However, for this to happen, additional molecular processes are critical to allow viral entry in cells, its replication and disease manifestation...
Articles
In Collection
ACE2, a multifunctional protein – from cardiovascular regulation to COVID-19
,
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (3): 535–554.
Published: 03 February 2021
... is the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is threating public health worldwide. The main complications of SARS-CoV-2 infected death patients include many energy metabolism-related chronic diseases, such as diabetes. The specific mechanism leading to this phenomenon...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (1): 1–17.
Published: 05 January 2021
...Ravindra K. Sharma; Jing Li; Suraj Krishnan; Elaine M. Richards; Mohan K. Raizada; Rajesh Mohandas The rapid spread of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought into focus the key role of angiotensin-converting enzyme 2 (ACE2), which serves...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (23): 3137–3158.
Published: 07 December 2020
... is hijacked by SARS-CoV-2 as a cellular receptor to gain entry to alveolar epithelial cells, causing COVID-19, a severe respiratory disease in humans. COVID-19 is frequently life-threatening especially in elderly or people with other medical conditions. As an unprecedented number of COVID-19 patients have...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2791–2805.
Published: 02 November 2020
... localization of ACE2 within the kidney and the importance of this enzyme in the metabolism of Angiotensin II and the formation of Angiotensin 1–7. With the recognition early in 2020 of ACE2 being the main receptor of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2), the interest in this protein has...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2315–2317.
Published: 09 September 2020
... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) . Coronavirus COVID-19 signaling pathway SARS-CoV-2 The authors...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2235–2241.
Published: 01 September 2020
...Mohamad Aman Jairajpuri; Shoyab Ansari Human serine protease inhibitors (serpins) are the main inhibitors of serine proteases, but some of them also have the capability to effectively inhibit cysteine proteases. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease (Mpro...
Articles
In Collection
Coronavirus
Daniella S. Battagello, Guilherme Dragunas, Marianne O. Klein, Ana L.P. Ayub, Fernando J. Velloso, Ricardo G. Correa
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (16): 2137–2160.
Published: 21 August 2020
...Daniella S. Battagello; Guilherme Dragunas; Marianne O. Klein; Ana L.P. Ayub; Fernando J. Velloso; Ricardo G. Correa The highly infective coronavirus disease 19 (COVID-19) is caused by a novel strain of coronaviruses – the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – discovered...
Articles
In Collection
Coronavirus
Thiago Gomes Heck, Mirna Stela Ludwig, Matias Nunes Frizzo, Alberto Antonio Rasia-Filho, Paulo Ivo Homem de Bittencourt, Jr
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (15): 1991–2017.
Published: 04 August 2020
...”. Interestingly, some species of bats that are natural reservoirs of zoonotic viruses, including SARS-CoV-2, possess an IFN-based antiviral inflammatory response perpetually activated but do not show any sign of disease or cytokine storm. This is possible because bats present a constitutive HSR that is by far...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1301–1304.
Published: 16 June 2020
...Jameel M. Inal The novel strain of coronavirus that appeared in 2019, SARS-CoV-2, is the causative agent of severe respiratory disease, COVID-19, and the ongoing pandemic. As for SARS-CoV that caused the SARS 2003 epidemic, the receptor on host cells that promotes uptake, through attachment...
Articles
In Collection
Coronavirus
Katharina Lanza, Lucas G. Perez, Larissa B. Costa, Thiago M. Cordeiro, Vitria A. Palmeira, Victor T. Ribeiro, Ana Cristina Simões e Silva
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (11): 1259–1264.
Published: 08 June 2020
...Katharina Lanza; Lucas G. Perez; Larissa B. Costa; Thiago M. Cordeiro; Vitria A. Palmeira; Victor T. Ribeiro; Ana Cristina Simões e Silva The emergency of SARS-CoV-2 in China started a novel challenge to the scientific community. As the virus turns pandemic, scientists try to map the cellular...
Articles
In Collection
Coronavirus
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (10): 1143–1150.
Published: 22 May 2020
...Sayeed ur Rehman; Mohammad Tabish Angiotensin-converting enzyme 2 (ACE2) plays an essential role in maintaining the balance of the renin–angiotensin system and also serves as a receptor for the SARS-CoV-2, SARS-CoV, and HCoV-NL63. Following the recent outbreak of SARS-CoV-2 infection, there has...
Includes: Supplementary data