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Keywords: Senescence
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Articles
Clin Sci (Lond) (2021) 135 (10): 1209–1212.
Published: 20 May 2021
.... In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described. Correspondence: Anton J.M...
Articles
Clin Sci (Lond) (2020) 134 (20): 2681–2706.
Published: 21 October 2020
... show signs of growth arrest and resistance to apoptosis, which are indicative of cellular senescence. It was recently postulated that cellular senescence contributes to the pathogenesis of chronic fibrotic diseases in the heart, kidney, liver and lung. Senescent cells negatively impact tissue...
Articles
Clin Sci (Lond) (2020) 134 (7): 889–905.
Published: 17 April 2020
...Michael Schuliga; Jane Read; Kaj E.C. Blokland; David W. Waters; Janette Burgess; Cecilia Prêle; Steven E. Mutsaers; Jade Jaffar; Glen Westall; Andrew Reid; Allen James; Christopher Grainge; Darryl A. Knight Senescence and mitochondrial stress are mutually reinforcing age-related processes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 315–330.
Published: 30 January 2020
... senescence is one of the common features in obesity and ageing. Although cellular senescence is a defensive mechanism preventing tumorigenesis, its occurrence in adipose tissue causatively induces defective adipogenesis, inflammation, aberrant adipocytokines production and insulin resistance, leading...
Articles
Clin Sci (Lond) (2018) 132 (3): 313–325.
Published: 02 February 2018
... and CHD is well documented; the accumulation of senescent cells in cardiac and vascular tissues may represent one factor underpinning this observation. We aimed to identify senescence-related expression changes in primary human senescent cardiomyocytes and endothelial cells and to relate transcript...
Articles
Clin Sci (Lond) (2012) 122 (5): 239–251.
Published: 08 November 2011
.... In the present study, we have determined the consequences of HO-1 (haem oxygenase-1) induction on markers of inflammation and senescence in the functional unit cartilage–subchondral bone stimulated with IL-1β. Cartilage–subchondral bone specimens were obtained from the knees of osteoarthritic patients. Treatment...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 121 (8): 343–353.
Published: 24 June 2011
... medium)/F12 medium (Sigma), supplemented with 10% (v/v) FBS (fetal bovine serum; Gibco) and 100 units/ml penicillin/streptomycin (Sigma) in an atmosphere of 5% CO 2 at 37°C [ 7 , 13 ]. antitumour cytotoxicity exercise hypoxia natural killer cell senescence Natural cytotoxicity...
Articles
Clin Sci (Lond) (2010) 119 (9): 373–387.
Published: 23 July 2010
... on whether protein restriction was imposed during pregnancy or lactation. The differentially expressed genes were involved in diverse biological functions such as cytoprotective functions, vitamin D synthesis, protein homoeostasis, regulation of antioxidant enzymes and cellular senescence. Significantly, up...
Includes: Supplementary data