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Articles

Evaluating skeletal muscle wasting and weakness in models of critical illness

Amy J. Bongetti, Marissa K. Caldow, Yasmine Ali Abdelhamid, Gordon S. Lynch

Clin Sci (Lond) (2025) 139 (13): 743–767.

https://doi.org/10.1042/CS20255458

Published: 01 July 2025

..., but not limited to, critical illness myopathy and sepsis-induced myopathy. Pre-clinical models of critical illness can provide insights into the mechanisms underlying muscle wasting and weakness. Cell culture systems can provide mechanistic interrogation, by isolating effects to skeletal muscle directly. Small...

View article titled, Evaluating skeletal muscle wasting and weakness in models of critical illness

Articles

Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients

Mark C. Chappell, Christopher L. Schaich, Laurence W. Busse, D. Clark Files, Greg S. Martin, Jonathan E. Sevransky, Jeremiah S. Hinson, Richard E. Rothman, Ashish K. Khanna, Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Investigators

Clin Sci (Lond) (2025) 139 (1): 43–53.

https://doi.org/10.1042/CS20242168

Published: 15 January 2025

...Mark C. Chappell; Christopher L. Schaich; Laurence W. Busse; D. Clark Files; Greg S. Martin; Jonathan E. Sevransky; Jeremiah S. Hinson; Richard E. Rothman; Ashish K. Khanna; Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Investigators Sepsis and septic shock are global healthcare problems...

View article titled, Higher circulating ACE2 and DPP3 but reduced ACE and angiotensinogen in hyperreninemic sepsis patients

Includes: Supplementary data

Articles

Inflammatory liver diseases and susceptibility to sepsis

Hong Lu

Clin Sci (Lond) (2024) 138 (7): 435–487.

https://doi.org/10.1042/CS20230522

Published: 04 April 2024

...Hong Lu Patients with inflammatory liver diseases, particularly alcohol-associated liver disease and metabolic dysfunction-associated fatty liver disease (MAFLD), have higher incidence of infections and mortality rate due to sepsis. The current focus in the development of drugs for MAFLD...

View article titled, Inflammatory liver diseases and susceptibility to sepsis

Articles

Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention

Ying Fu, Yu Xiang, Jie Zha, Guochun Chen, Zheng Dong

Clin Sci (Lond) (2024) 138 (6): 351–369.

https://doi.org/10.1042/CS20240059

Published: 12 March 2024

... contributed equally to this work. 10 01 2024 20 02 2024 26 02 2024 27 02 2024 © 2024 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2024 Acute kidney injury apoptosis inflammation mTOR sepsis STAT3 National Natural...

View article titled, Enhanced STAT3/PIK3R1/mTOR signaling triggers tubular cell inflammation and apoptosis in septic-induced acute kidney injury: implications for therapeutic intervention

Includes: Supplementary data

Articles

Destabilisation of T cell-dependent humoral immunity in sepsis

Kate Davies, James E. McLaren

Clin Sci (Lond) (2024) 138 (1): 65–85.

https://doi.org/10.1042/CS20230517

Published: 10 January 2024

...Kate Davies; James E. McLaren Sepsis is a heterogeneous condition defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. For some, sepsis presents as a predominantly suppressive disorder, whilst others experience a pro-inflammatory condition which can...

View article titled, Destabilisation of T cell-dependent humoral immunity in sepsis

Articles

PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway

Wang Ze Tian, Qi Yue, Wang Fei, Peng Zi Yao, Rui Qin Han, Jianguo Tang

Clin Sci (Lond) (2023) 137 (22): 1753–1769.

https://doi.org/10.1042/CS20230704

Published: 22 November 2023

...Wang Ze Tian; Qi Yue; Wang Fei; Peng Zi Yao; Rui Qin Han; Jianguo Tang Sepsis is known to cause damage to the intestinal mucosa, leading to bacterial translocation, and exacerbation of both local and remote organ impairments. In the present study, fecal samples were collected from both septic...

View article titled, PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway

Articles

Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway

Shuan Dong, Shasha Liu, Qiaoying Gao, Jia Shi, Kai Song, Ya Wu, Huayang Liu, Chenxu Guo, Yan Huang, Shihan Du, Xiangyun Li, Lixiu Ge, Jianbo Yu

Clin Sci (Lond) (2023) 137 (18): 1499–1512.

https://doi.org/10.1042/CS20230354

Published: 26 September 2023

...Shuan Dong; Shasha Liu; Qiaoying Gao; Jia Shi; Kai Song; Ya Wu; Huayang Liu; Chenxu Guo; Yan Huang; Shihan Du; Xiangyun Li; Lixiu Ge; Jianbo Yu Background: Sepsis engenders an imbalance in the body’s inflammatory response, with cytokines assuming a pivotal role in its progression. A relatively...

View article titled, Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway

Includes: Supplementary data

Articles

Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection

Valerie E. Polcz, Evan L. Barrios, Benjamin Chapin, Catherine C. Price, Ravinder Nagpal, Paramita Chakrabarty, Gemma Casadesus, Thomas Foster, Lyle L. Moldawer, Philip A. Efron

Clin Sci (Lond) (2023) 137 (12): 963–978.

https://doi.org/10.1042/CS20220555

Published: 20 June 2023

... system. Male sex has been associated with increased susceptibility to infection, as well as increased risk of adverse outcomes. Sepsis remains a major source of morbidity and mortality globally, and over half of septic patients admitted to intensive care are believed to suffer some degree of sepsis...

View article titled, Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection

Articles

Cancer and sepsis

Jeroson C. Williams, Mandy L. Ford, Craig M. Coopersmith

Clin Sci (Lond) (2023) 137 (11): 881–893.

https://doi.org/10.1042/CS20220713

Published: 14 June 2023

...Jeroson C. Williams; Mandy L. Ford; Craig M. Coopersmith Sepsis is one of the leading causes of death worldwide. While mortality is high regardless of inciting infection or comorbidities, mortality in patients with cancer and sepsis is significantly higher than mortality in patients with sepsis...

View article titled, Cancer and sepsis

Articles

The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Miranda J. Melis, Muska Miller, Vera B.M. Peters, Mervyn Singer

Clin Sci (Lond) (2023) 137 (9): 707–725.

https://doi.org/10.1042/CS20220709

Published: 05 May 2023

...Miranda J. Melis; Muska Miller; Vera B.M. Peters; Mervyn Singer Sepsis is a dysregulated host response to infection that results in life-threatening organ dysfunction. Virtually every body system can be affected by this syndrome to greater or lesser extents. Gene transcription and downstream...

View article titled, The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

Articles

The leaky gut and the gut microbiome in sepsis – targets in research and treatment

Wiwat Chancharoenthana, Supitcha Kamolratanakul, Marcus J. Schultz, Asada Leelahavanichkul

Clin Sci (Lond) (2023) 137 (8): 645–662.

https://doi.org/10.1042/CS20220777

Published: 21 April 2023

...Wiwat Chancharoenthana; Supitcha Kamolratanakul; Marcus J. Schultz; Asada Leelahavanichkul Both a leaky gut (a barrier defect of the intestinal surface) and gut dysbiosis (a change in the intestinal microbial population) are intrinsic to sepsis. While sepsis itself can cause dysbiosis, dysbiosis...

View article titled, The leaky gut and the gut microbiome in sepsis – targets in research and treatment

Articles

Neurochemical effects of sepsis on the brain

Tatiana Barichello, Vijayasree V Giridharan, Carlos Henrique R Catalão, Cristiane Ritter, Felipe Dal-Pizzol

Clin Sci (Lond) (2023) 137 (6): 401–414.

https://doi.org/10.1042/CS20220549

Published: 21 March 2023

...Tatiana Barichello; Vijayasree V Giridharan; Carlos Henrique R Catalão; Cristiane Ritter; Felipe Dal-Pizzol Sepsis is a life-threatening organ dysfunction triggered by a dysregulated host immune response to eliminate an infection. After the host immune response is activated, a complex, dynamic...

View article titled, Neurochemical effects of sepsis on the brain

Articles

The double sides of NLRP3 inflammasome activation in sepsis

Clara Vigneron, Bénédicte F. Py, Guillaume Monneret, Fabienne Venet

Clin Sci (Lond) (2023) 137 (5): 333–351.

https://doi.org/10.1042/CS20220556

Published: 01 March 2023

...Clara Vigneron; Bénédicte F. Py; Guillaume Monneret; Fabienne Venet Sepsis is defined as a life-threatening organ dysfunction induced by a dysregulated host immune response to infection. Immune response induced by sepsis is complex and dynamic. It is schematically described as an early dysregulated...

View article titled, The double sides of NLRP3 inflammasome activation in sepsis

Articles

PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Honglin Li, Zhiwen Liu, Ying Wang, Hui Wang, Juan Cai, Chengyuan Tang, Zheng Dong

Clin Sci (Lond) (2022) 136 (24): 1877–1891.

https://doi.org/10.1042/CS20220493

Published: 22 December 2022

...Honglin Li; Zhiwen Liu; Ying Wang; Hui Wang; Juan Cai; Chengyuan Tang; Zheng Dong Sepsis is a leading cause of acute kidney injury (AKI), and the pathogenesis of septic AKI remains largely unclear. Parkinson disease protein 7 (PARK7) is a protein of multiple functions that was recently implicated...

View article titled, PARK7 is induced to protect against endotoxic acute kidney injury by suppressing NF-κB

Articles

Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Clin Sci (Lond) (2022) 136 (13): 1045.

https://doi.org/10.1042/CS-2021-1003C_COR

Published: 04 July 2022

... © 2022 The Author(s). 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Critical Illness Fasting Hypercortisolemia Ketogenesis Sepsis Tight...

View article titled, Correction: Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Articles

Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Arno Téblick, Jan Gunst, Lies Langouche, Greet Van den Berghe

Clin Sci (Lond) (2022) 136 (11): 861–878.

https://doi.org/10.1042/CS20211003

Published: 01 June 2022

...Arno Téblick; Jan Gunst; Lies Langouche; Greet Van den Berghe Sepsis is defined as any life-threatening organ dysfunction caused by a dysregulated host response to infection. It remains an important cause of critical illness and has considerable short- and long-term morbidity and mortality...

View article titled, Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

Articles

Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Thiele Osvaldt Rosales, Verônica Vargas Horewicz, Marcella Amorim Ferreira, Geisson Marcos Nardi, Jamil Assreuy

Clin Sci (Lond) (2021) 135 (20): 2341–2356.

https://doi.org/10.1042/CS20210462

Published: 18 October 2021

...Thiele Osvaldt Rosales; Verônica Vargas Horewicz; Marcella Amorim Ferreira; Geisson Marcos Nardi; Jamil Assreuy Renal vascular reactivity to vasoconstrictors is preserved in sepsis in opposition to what happens in the systemic circulation. We studied whether this distinct behavior was related to α1...

View article titled, Dynamics of GRK2 in the kidney: a putative mechanism for sepsis-associated kidney injury

Articles

Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs

Manasi Nandi, Simon K. Jackson, Duncan Macrae, Manu Shankar-Hari, Jordi L. Tremoleda, Elliot Lilley

Clin Sci (Lond) (2020) 134 (13): 1715–1734.

https://doi.org/10.1042/CS20200679

Published: 10 July 2020

...Manasi Nandi; Simon K. Jackson; Duncan Macrae; Manu Shankar-Hari; Jordi L. Tremoleda; Elliot Lilley Sepsis is a major worldwide healthcare issue with unmet clinical need. Despite extensive animal research in this area, successful clinical translation has been largely unsuccessful. We propose one...

View article titled, Rethinking animal models of sepsis – working towards improved clinical translation whilst integrating the 3Rs

Articles

Correction: Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis

Clin Sci (Lond) (2020) 134 (13): 1677.

https://doi.org/10.1042/CS-20191322_COR

Published: 07 July 2020

... © 2020 The Author(s). 2020 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microglia M1/M2 sepsis neuroinflammation The authors of the original...

View article titled, Correction: Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis

Articles

Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis

Monique Michels, Mariane Abatti, Andriele Vieira, Pricila Ávila, Amanda Indalécio Goulart, Heloisa Borges, Emily Córneo, Diogo Dominguini, Tatiana Barichello, Felipe Dal-Pizzol

Clin Sci (Lond) (2020) 134 (7): 765–776.

https://doi.org/10.1042/CS20191322

Published: 07 April 2020

... of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of microglial phenotypes in sepsis-induced brain dysfunction. Methods: Wistar rats were submitted to sham or cecal ligation and perforation (CLP) and treated...

View article titled, Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis

Articles

Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model

Andressa Manfredini, Larissa Constantino, Milton Castro Pinto, Monique Michels, Henrique Burger, Luiza W. Kist, Milena Carvalho Silva, Lara Mezzari Gomes, Diogo Dominguini, Amanda Steckert, Carmen Simioni, Mauricio Bogo, Emílio Streck, Tatiana Barichello, João de Quevedo, Mervyn Singer, Cristiane Ritter, Felipe Dal-Pizzol

Clin Sci (Lond) (2019) 133 (18): 1993–2004.

https://doi.org/10.1042/CS20190351

Published: 24 September 2019

... Ritter; Felipe Dal-Pizzol Background: Several different mechanisms have been proposed to explain long-term cognitive impairment in sepsis survivors. The role of persisting mitochondrial dysfunction is not known. We thus sought to determine whether stimulation of mitochondrial dynamics improves...

View article titled, Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model

Includes: Supplementary data

Articles

TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury

Junhui Shen, Zhong-Kai Cui, Fang Yao, Kai Li, Yue Zhang, Zhenguo Chen, Yuxia Zhou, Song Xu, Yuwei Zhang, Wenqing Jiang, Hanbin Zhang, Kaifen Tan, Anling Liu, Xiaochun Bai

Clin Sci (Lond) (2018) 132 (19): 2087–2101.

https://doi.org/10.1042/CS20180348

Published: 02 October 2018

... (BUN) 14 h later confirmed successful establishment of the AKI sepsis model ( Figure 1 A). The number of p-S6 + interstitial renal cells increased, which indicated mTORC1 activity was up-regulated by LPS treatment ( Figure 1 B). Immunofluorescent co-staining with FSP1 and p-S6 antibodies confirmed...

View article titled, TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury

Includes: Supplementary data

Articles

Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis

Amel Komic, Patricia Martinez-Quinones, Cameron G. McCarthy, R. Clinton Webb, Camilla F. Wenceslau

Clin Sci (Lond) (2018) 132 (13): 1433–1438.

https://doi.org/10.1042/CS20180368

Published: 18 July 2018

...Amel Komic; Patricia Martinez-Quinones; Cameron G. McCarthy; R. Clinton Webb; Camilla F. Wenceslau Sepsis is a profoundly morbid and life-threatening condition, and an increasingly alarming burden on modern healthcare economies. Patients with septic shock exhibit persistent hypotension despite...

View article titled, Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis

Articles

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

Jerome Morel, Iain Hargreaves, David Brealey, Viruna Neergheen, Janne T. Backman, Sandro Lindig, Marcus Bläss, Michael Bauer, Daniel F. McAuley, Mervyn Singer

Clin Sci (Lond) (2017) 131 (8): 747–758.

https://doi.org/10.1042/CS20160802

Published: 06 April 2017

...Jerome Morel; Iain Hargreaves; David Brealey; Viruna Neergheen; Janne T. Backman; Sandro Lindig; Marcus Bläss; Michael Bauer; Daniel F. McAuley; Mervyn Singer Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated...

View article titled, Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis

Includes: Supplementary data

Articles

Immature myeloid Gr-1 + CD11b + cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function

Veronica I. Landoni, Daiana Martire-Greco, Nahuel Rodriguez-Rodrigues, Paula Chiarella, Pablo Schierloh, Martin A. Isturiz, Gabriela C. Fernández

Clin Sci (Lond) (2016) 130 (4): 259–271.

https://doi.org/10.1042/CS20150653

Published: 14 January 2016

...Veronica I. Landoni; Daiana Martire-Greco; Nahuel Rodriguez-Rodrigues; Paula Chiarella; Pablo Schierloh; Martin A. Isturiz; Gabriela C. Fernández Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis. Repetitive inoculation of increasing doses...

View article titled, Immature myeloid Gr-1 + CD11b + cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function

Includes: Supplementary data

Articles

Metabolic dysfunction in lymphocytes promotes postoperative morbidity

Mark R. Edwards, Pervez Sultan, Ana Gutierrez del Arroyo, John Whittle, Shamir N. Karmali, S. Ramani Moonesinghe, Fares S. Haddad, Michael G. Mythen, Mervyn Singer, Gareth L. Ackland

Clin Sci (Lond) (2015) 129 (5): 423–437.

https://doi.org/10.1042/CS20150024

Published: 11 June 2015

.... This hypometabolic phenotype triggered by glucocorticoid-induced mitochondrial dysfunction activating the NLRP1 inflammasome prevents normal lymphocyte functionality and increases apoptosis. apoptosis inflammasome lymphocyte metabolism mitochondria sepsis • The mechanism underlying a potential...

View article titled, Metabolic dysfunction in lymphocytes promotes postoperative morbidity

Includes: Supplementary data

Articles

Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis

Ting He, Jiongyu Hu, Guangning Yan, Lingfei Li, Dongxia Zhang, Qiong Zhang, Bing Chen, Yuesheng Huang

Clin Sci (Lond) (2015) 129 (1): 49–61.

https://doi.org/10.1042/CS20140631

Published: 01 April 2015

...Ting He; Jiongyu Hu; Guangning Yan; Lingfei Li; Dongxia Zhang; Qiong Zhang; Bing Chen; Yuesheng Huang The integrity of the vascular barrier, which is essential to blood vessel homoeostasis, can be disrupted by a variety of soluble permeability factors during sepsis. Pigment epithelium-derived...

View article titled, Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis

Includes: Supplementary data

Articles

Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability

Yvette C. Luiking, Martijn Poeze, Nicolaas E. Deutz

Clin Sci (Lond) (2015) 128 (1): 57–67.

https://doi.org/10.1042/CS20140343

Published: 29 August 2014

...Yvette C. Luiking; Martijn Poeze; Nicolaas E. Deutz Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present...

View article titled, Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability

Includes: Supplementary data

Articles

Identification of four novel serum protein biomarkers in sepsis patients encoded by target genes of sepsis-related miRNAs

Hui-juan Wang, Bao-zeng Wang, Peng-jun Zhang, Jie Deng, Zhi-rui Zhao, Xin Zhang, Kun Xiao, Dan Feng, Yan-hong Jia, You-ning Liu, Li-xin Xie

Clin Sci (Lond) (2014) 126 (12): 857–867.

https://doi.org/10.1042/CS20130301

Published: 05 March 2014

... with sepsis. The target genes were predicted by bioinformatics analysis; the levels of the respective proteins in the sera of patients with sepsis were detected by ELISA. ACVR2A (activin A receptor, type IIA), FOXO1 (forkhead box O1), IHH (Indian hedgehog), STK4 (serine/threonine kinase 4) and DUSP3 (dual...

View article titled, Identification of four novel serum protein biomarkers in sepsis patients encoded by target genes of sepsis-related miRNAs

Articles

all- trans -Retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression

Daiana Martire-Greco, Veronica I. Landoni, Paula Chiarella, Nahuel Rodriguez-Rodrigues, Pablo Schierloh, Barbara Rearte, Martin A. Isturiz, Gabriela C. Fernandez

Clin Sci (Lond) (2014) 126 (5): 355–365.

https://doi.org/10.1042/CS20130236

Published: 01 November 2013

...Daiana Martire-Greco; Veronica I. Landoni; Paula Chiarella; Nahuel Rodriguez-Rodrigues; Pablo Schierloh; Barbara Rearte; Martin A. Isturiz; Gabriela C. Fernandez Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis. Strategies aimed...

View article titled, all- trans -Retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression

Articles

P2X 7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction

Chin-Wei Chiao, J. Eduardo da Silva-Santos, Fernanda R. Giachini, Rita C. Tostes, Ming-Jai Su, R. Clinton Webb

Clin Sci (Lond) (2013) 125 (3): 131–141.

https://doi.org/10.1042/CS20120479

Published: 12 April 2013

...: Dr Chin-Wei Chiao (email [email protected] ). 5 9 2012 16 1 2013 7 3 2013 7 3 2013 • There are no efficacious strategies to prevent or treat sepsis/septic shock, since it is very difficult to block multiple downstream pro-inflammatory factor activations...

View article titled, P2X 7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction

Articles

Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

Hadj Ahmed Mostefai, Jean-Michel Bourget, Ferhat Meziani, Maria Carmen Martinez, Daniela Leonetti, Alain Mercat, Pierre Asfar, Lucie Germain, Ramaroson Andriantsitohaina

Clin Sci (Lond) (2013) 125 (2): 77–85.

https://doi.org/10.1042/CS20120441

Published: 26 March 2013

...Hadj Ahmed Mostefai; Jean-Michel Bourget; Ferhat Meziani; Maria Carmen Martinez; Daniela Leonetti; Alain Mercat; Pierre Asfar; Lucie Germain; Ramaroson Andriantsitohaina During sepsis, inflammation can be orchestrated by the interaction between circulating and vascular cells that, under activation...

View article titled, Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media

Articles

The promise and challenge of systems biology in translational medicine

Visith Thongboonkerd

Clin Sci (Lond) (2013) 124 (6): 389–390.

https://doi.org/10.1042/CS20120565

Published: 27 November 2012

... cycling in cardiac tissue of rats with early sepsis could discriminate survivors from non-survivors. These findings underscore the great potential of systems biology in translational medicine. However, further investigations should be done to make the benchside results more feasible for routine clinical...

View article titled, The promise and challenge of systems biology in translational medicine

Articles

Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Alain Rudiger, Alex Dyson, Karen Felsmann, Jane E. Carré, Valerie Taylor, Sian Hughes, Innes Clatworthy, Alessandro Protti, Denis Pellerin, Jana Lemm, Ralf A. Claus, Michael Bauer, Mervyn Singer

Clin Sci (Lond) (2013) 124 (6): 391–401.

https://doi.org/10.1042/CS20120334

Published: 27 November 2012

...Alain Rudiger; Alex Dyson; Karen Felsmann; Jane E. Carré; Valerie Taylor; Sian Hughes; Innes Clatworthy; Alessandro Protti; Denis Pellerin; Jana Lemm; Ralf A. Claus; Michael Bauer; Mervyn Singer Myocardial function is depressed in sepsis and is an important prognosticator in the human condition...

View article titled, Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis

Includes: Supplementary data

Articles

Systems biology of antioxidants

Ramaroson Andriantsitohaina, Lucie Duluc, Julio C. García-Rodríguez, Lizette Gil-del Valle, Mariela Guevara-Garcia, Gilles Simard, Raffaella Soleti, Ding-Feng Su, Luis Velásquez-Pérez, John X. Wilson, Ismail Laher

Clin Sci (Lond) (2012) 123 (3): 173–192.

https://doi.org/10.1042/CS20110643

Published: 12 April 2012

... of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia...

View article titled, Systems biology of antioxidants

Articles

Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis

Maria Klaude, Maiko Mori, Inga Tjäder, Thomas Gustafsson, Jan Wernerman, Olav Rooyackers

Clin Sci (Lond) (2012) 122 (3): 133–142.

https://doi.org/10.1042/CS20110233

Published: 11 October 2011

..., we investigated whether muscle protein degradation is increased in critically ill patients with sepsis and which proteolytic enzyme systems are involved in this degradation. Eight patients and seven healthy volunteers were studied. In vivo muscle protein kinetics was measured using arteriovenous...

View article titled, Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis

Articles

Protein metabolism in leg muscle following an endotoxin injection in healthy volunteers

Rokhsareh F. Vesali, Norbert Cibicek, Towe Jakobsson, Maria Klaude, Jan Wernerman, Olav Rooyackers

Clin Sci (Lond) (2010) 118 (6): 421–427.

https://doi.org/10.1042/CS20090332

Published: 14 December 2009

...Rokhsareh F. Vesali; Norbert Cibicek; Towe Jakobsson; Maria Klaude; Jan Wernerman; Olav Rooyackers The human endotoxin model has been used to study the early phase of sepsis. The aim of the present study was to assess leg muscle protein kinetics after an endotoxin challenge given to healthy human...

View article titled, Protein metabolism in leg muscle following an endotoxin injection in healthy volunteers

Articles

Circulating and muscle glutathione turnover in human endotoxaemia

Urban B. Fläring, Christina Hebert, Jan Wernerman, Folke Hammarqvist, Olav E. Rooyackers

Clin Sci (Lond) (2009) 117 (9): 313–319.

https://doi.org/10.1042/CS20080462

Published: 01 September 2009

... of glutathione status and glutathione kinetics in healthy volunteers during the initial phase of sepsis using a human endotoxin model. The present study was a descriptive pilot study in healthy male volunteers ( n =8) before and after an endotoxin challenge. The glutathione status was determined in plasma...

View article titled, Circulating and muscle glutathione turnover in human endotoxaemia

Articles

Altered plasma proteome during an early phase of peritonitis-induced sepsis

Visith Thongboonkerd, Wararat Chiangjong, Jan Mares, Jiri Moravec, Zdenek Tuma, Thomas Karvunidis, Supachok Sinchaikul, Shui-Tein Chen, Karel Opatrný, Jr, Martin Matejovic

Clin Sci (Lond) (2009) 116 (9): 721–730.

https://doi.org/10.1042/CS20080478

Published: 02 April 2009

...Visith Thongboonkerd; Wararat Chiangjong; Jan Mares; Jiri Moravec; Zdenek Tuma; Thomas Karvunidis; Supachok Sinchaikul; Shui-Tein Chen; Karel Opatrný, Jr; Martin Matejovic Sepsis is a systemic response to infection commonly found in critically ill patients and is associated with multi-organ failure...

View article titled, Altered plasma proteome during an early phase of peritonitis-induced sepsis

Includes: Supplementary data

Articles

Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis

Pisake Boontham, Adrian Robins, Palanichamy Chandran, David Pritchard, Miguel Cámara, Paul Williams, Suebwong Chuthapisith, Alasdair McKechnie, Brian J. Rowlands, Oleg Eremin

Clin Sci (Lond) (2008) 115 (11): 343–351.

https://doi.org/10.1042/CS20080018

Published: 03 November 2008

... studies have demonstrated the immunomodulatory effects of quorum-sensing signal molecules. In the present study, we have examined the impact of these molecules on normal human immune function in vitro and compared this with immune changes in patients with sepsis where quorum-sensing signal molecules were...

View article titled, Significant immunomodulatory effects of Pseudomonas aeruginosa quorum-sensing signal molecules: possible link in human sepsis

Articles

Use of multiple fluorophores for evaluating microvascular permeability in control rats and rats with sepsis

Ragheb A. Assaly, Robert H. Habib, Mustafa Azizi, Joseph I. Shapiro, J. David Dignam

Clin Sci (Lond) (2008) 114 (2): 123–130.

https://doi.org/10.1042/CS20070219

Published: 11 December 2007

... is reported at the P <0.05 level. albumin capillary leak fluorophore poly(ethylene glycol) redistribution phase sepsis vascular permeability Attaching PEG [poly(ethylene glycol)] to proteins (PEGylation) increases their intravascular retention time [ t ½ (half-life)] by decreasing...

View article titled, Use of multiple fluorophores for evaluating microvascular permeability in control rats and rats with sepsis

Articles

Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis

Maria Klaude, Katarina Fredriksson, Inga Tjäder, Folke Hammarqvist, Bo Ahlman, Olav Rooyackers, Jan Wernerman

Clin Sci (Lond) (2007) 112 (9): 499–506.

https://doi.org/10.1042/CS20060265

Published: 02 April 2007

...Maria Klaude; Katarina Fredriksson; Inga Tjäder; Folke Hammarqvist; Bo Ahlman; Olav Rooyackers; Jan Wernerman Patients with sepsis in the ICU (intensive care unit) are characterized by skeletal muscle wasting. This leads to muscle dysfunction that also influences the respiratory capacity, resulting...

View article titled, Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis

Articles

Increased cationic amino acid flux through a newly expressed transporter in cells overproducing nitric oxide from patients with septic shock

Michael C. READE, Megan F. CLARK, J. Duncan YOUNG, C.A.R. BOYD

Clin Sci (Lond) (2002) 102 (6): 645–650.

https://doi.org/10.1042/cs1020645

Published: 14 May 2002

...Michael C. READE; Megan F. CLARK; J. Duncan YOUNG; C.A.R. BOYD Increased production of nitric oxide (NO) is thought to be a factor in the pathogenesis of many human diseases - among them the hypotension that often accompanies sepsis. The supply of the cationic amino acid arginine is known...

View article titled, Increased cationic amino acid flux through a newly expressed transporter in cells overproducing nitric oxide from patients with septic shock

Articles

Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat

Michael J. O'LEARY, Colin N. FERGUSON, Michael J. RENNIE, Charles J. HINDS, John H. COAKLEY, Victor R. PREEDY

Clin Sci (Lond) (2001) 101 (3): 295–304.

https://doi.org/10.1042/cs1010295

Published: 15 August 2001

...Michael J. O'LEARY; Colin N. FERGUSON; Michael J. RENNIE; Charles J. HINDS; John H. COAKLEY; Victor R. PREEDY We have investigated sequential changes in skeletal muscle and hepatic protein synthesis following sepsis, and their relationship to changes in circulating and tissue glutamine...

View article titled, Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat

Articles

Iron signalling regulated directly and through oxygen: implications for sepsis and the acute respiratory distress syndrome

G. J. QUINLAN, Y. CHEN, T. W. EVANS, J. M. C. GUTTERIDGE

Clin Sci (Lond) (2001) 100 (2): 169–182.

https://doi.org/10.1042/cs1000169

Published: 02 January 2001

... the concept that iron (often viewed as the ‘villain’ in free radical biology) can also be considered as a signalling species. Iron is intimately involved in the regulation of its own storage, compartmentalization and turnover. During adult respiratory distress syndrome (ARDS) and sepsis, such regulation may...

View article titled, Iron signalling regulated directly and through oxygen: implications for sepsis and the acute respiratory distress syndrome

Articles

Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation and inhibition of nitric oxide synthase

Suveer SINGH, Peter B. ANNING, C. Peter WINLOVE, Timothy W. EVANS

Clin Sci (Lond) (2001) 100 (1): 81–89.

https://doi.org/10.1042/cs1000081

Published: 08 December 2000

...Suveer SINGH; Peter B. ANNING; C. Peter WINLOVE; Timothy W. EVANS Sepsis is characterized by increased microvascular permeability and regional variations in capillary perfusion, which may be modulated by nitric oxide (NO) and reversed by fluid resuscitation (FR). The effects of saline FR...

View article titled, Regional transcapillary albumin exchange in rodent endotoxaemia: effects of fluid resuscitation and inhibition of nitric oxide synthase

Articles

Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice

Quan WANG, Xiaoyan SUN, Timothy A. PRITTS, Hector R. WONG, Per-Olof HASSELGREN

Clin Sci (Lond) (2000) 99 (6): 489–496.

https://doi.org/10.1042/cs0990489

Published: 07 November 2000

...Quan WANG; Xiaoyan SUN; Timothy A. PRITTS; Hector R. WONG; Per-Olof HASSELGREN Previous studies suggest that production of interleukin-6 (IL-6) is increased in the intestinal mucosa during sepsis and endotoxaemia. We tested the hypothesis that mucosal IL-6 production during endotoxaemia...

View article titled, Induction of the stress response increases interleukin-6 production in the intestinal mucosa of endotoxaemic mice

Articles

Insulin sensitivity of glucose and fat metabolism in severe sepsis

Cécile CHAMBRIER, Martine LAVILLE, Khalid RHZIOUAL BERRADA, Michelle ODEON, Paul BOULÉTREAU, Michel BEYLOT

Clin Sci (Lond) (2000) 99 (4): 321–328.

https://doi.org/10.1042/cs0990321

Published: 05 September 2000

...Cécile CHAMBRIER; Martine LAVILLE; Khalid RHZIOUAL BERRADA; Michelle ODEON; Paul BOULÉTREAU; Michel BEYLOT In order to quantify the changes in insulin sensitivity, particularly of endogenous glucose production and fat metabolism, in patients with severe sepsis, a prospective study was conducted...

View article titled, Insulin sensitivity of glucose and fat metabolism in severe sepsis

Articles

Noradrenaline and Nω-monomethyl-L-arginine (L-NMMA): effects on haemodynamics and regional blood flow in healthy and septic sheep

M. BOOKE, F. HINDER, R. MCGUIRE, L. D. TRABER, D. L. TRABER

Clin Sci (Lond) (2000) 98 (2): 193–200.

https://doi.org/10.1042/cs0980193

Published: 11 January 2000

... increase in blood pressure as observed in matched sheep of the l -NMMA group (non-septic phase). Treatment was discontinued after 3 h. Sepsis was initiated and maintained by a continuous infusion of live Pseudomonas aeruginosa . After 24 h of sepsis, the sheep were again challenged over a treatment period...

View article titled, Noradrenaline and Nω-monomethyl-L-arginine (L-NMMA): effects on haemodynamics and regional blood flow in healthy and septic sheep

Articles

Markers of systemic inflammation predicting organ failure in community-acquired septic shock

Annika TAKALA, Irma JOUSELA, Sten-Erik JANSSON, Klaus T. OLKKOLA, Olli TAKKUNEN, Arto ORPANA, Sirkka-Liisa KARONEN, Heikki REPO

Clin Sci (Lond) (1999) 97 (5): 529–538.

https://doi.org/10.1042/cs0970529

Published: 15 September 1999

... and monocytes, and higher concentrations of IL-6, IL-8 and sIL-2R. C-reactive protein and soluble E-selectin concentrations did not differ between groups. No parameter alone identified all patients that subsequently developed OF. However, a sepsis-related inflammation severity score (SISS), developed...

View article titled, Markers of systemic inflammation predicting organ failure in community-acquired septic shock

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