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Keywords: Skeletal muscle
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Clin Sci (Lond) (2024) 138 (14): 863–882.
Published: 12 July 2024
...’ (the length of time spent in a healthy, disease-free state) has also increased, with skeletal muscle being a substantial contributor to this. Biological ageing is accompanied by declines in both skeletal muscle mass and function, termed sarcopenia. The mechanisms underpinning sarcopenia are multifactorial...
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Clin Sci (Lond) (2024) 138 (12): 741–756.
Published: 19 June 2024
...Colleen S. Deane; Matthew Piasecki; Philip J. Atherton Periods of skeletal muscle disuse lead to rapid declines in muscle mass (atrophy), which is fundamentally underpinned by an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown (MPB). The complex interplay of molecular...
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Clin Sci (Lond) (2023) 137 (17): 1391–1407.
Published: 07 September 2023
... -like receptor agonist, fenoldopam. Furthermore, the expression of D 1 R was decreased in skeletal muscles from streptozotocin (STZ)- and high-fat intake-induced T2DM mice, accompanied by increased D 1 R phosphorylation, which was reversed by exercise. A screening study showed that G protein-coupled...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (16): 1311–1332.
Published: 31 August 2023
.... Extracellular Vesicles insulin resistance microRNA Pregnancy skeletal muscle EVs were first described by Peter Wolf in blood coagulation studies using transmission electron microscopy and were described as cell waste [ 89 ]. However, substantial research in this area revealed that these membrane...
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Clin Sci (Lond) (2022) 136 (14): 1081–1110.
Published: 27 July 2022
...Chantal A. Pileggi; Breana G. Hooks; Ruth McPherson; Robert R.M. Dent; Mary-Ellen Harper Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content...
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Clin Sci (Lond) (2021) 135 (7): 979–990.
Published: 16 April 2021
... regulators of myogenic factors to regulate muscle development. The present study aimed to investigate the physical exercise impact on insulin-like growth factor 2 (IGF2) and analyzed its functions on skeletal muscle cells in vitro . Using online databases, we stated that IGF2 was relatively highly expressed...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (22): 3047–3062.
Published: 24 November 2020
...-7 (Ang 1-7), which is considered to exert cellular responses to counteract the activation of the RAS primarily through a receptor, Mas, in multiple organs including skeletal muscle. Previous studies have provided abundant evidence suggesting that Ang 1-7 modulates multiple signalling pathways...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (21): 2835–2850.
Published: 04 November 2020
...Maarten M. Steinz; Estela Santos-Alves; Johanna T. Lanner Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and the presence of serum autoantibodies. In addition, skeletal muscle weakness is a common comorbidity that contributes to inability to work and reduced...
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Clin Sci (Lond) (2020) 134 (16): 2177–2187.
Published: 26 August 2020
...Edmund Battey; Matthew J. Stroud; Julien Ochala Skeletal muscle weakness is an important determinant of age-related declines in independence and quality of life but its causes remain unclear. Accelerated ageing syndromes such as Hutchinson–Gilford Progerin Syndrome, caused by mutations in genes...
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Clin Sci (Lond) (2017) 131 (13): 1437–1447.
Published: 23 June 2017
... on skeletal muscle protein maintenance and carbohydrate metabolism during lipopolysaccharide (LPS)-induced endotoxaemia. Sprague-Dawley rats were fed either standard chow (control) or standard chow containing Rosi (8.5 ± 0.1 mg·kg −1 ·day −1 ) for 2 weeks before and during 24 h continuous intravenous infusion...
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Clin Sci (Lond) (2016) 130 (24): 2245–2256.
Published: 04 November 2016
...). published by Portland Press Limited on behalf of the Biochemical Society 2016 large intervening non-coding RNA myocardium non-coding RNA skeletal muscle therapeutics Perhaps one of the least understood aspects of lncRNAs is how these molecules influence cellular processes. Adding...
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Clin Sci (Lond) (2016) 130 (1): 35–44.
Published: 30 November 2015
... involves activation of ATP-sensitive K + channels and phosphodiesterase inhibition. As both mechanisms are potentially involved in malignant hyperthermia (MH), in the present study we addressed the involvement of the L -cysteine/hydrogen sulfide pathway in MH. Skeletal muscle biopsies obtained from 25 MH...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 128 (6): 357–365.
Published: 28 November 2014
...Marlou L. Dirks; Dominique Hansen; Aimé Van Assche; Paul Dendale; Luc J. C. Van Loon Fully sedated patients, being treated in the intensive care unit (ICU), experience substantial skeletal muscle loss. Consequently, survival rate is reduced and full recovery after awakening is compromised...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (11): 611–625.
Published: 01 August 2012
... miRNAs are also essential for muscle function. In the present review, we outline the miRNAs involved in embryonic muscle development and those that have been found to be dysregulated in diseases associated with skeletal muscle or are changed during muscle adaptation. miRNAs are promising biomarkers...
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Clin Sci (Lond) (2010) 118 (8): 507–518.
Published: 26 January 2010
...Sean L. McGee; Mark Hargreaves Skeletal muscle phenotype plays a critical role in human performance and health, and skeletal muscle oxidative capacity is a key determinant of exercise tolerance. More recently, defective muscle oxidative metabolism has been implicated in a number of conditions...
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Clin Sci (Lond) (2010) 118 (6): 421–427.
Published: 14 December 2009
... phenylalanine from skeletal muscle, whereas protein balance was unaffected. Both protein synthesis and breakdown were decreased to a similar extent. The subjects reported to the research unit in the morning of the study day after an overnight fast (from 20:00 hours the day before). Catheters were placed...
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Clin Sci (Lond) (2009) 117 (9): 313–319.
Published: 01 September 2009
... and whole blood at baseline and hourly for 4 h after intravenous endotoxin injection and in skeletal muscle at baseline and at 2 and 4 h after endotoxin injection. In plasma, the concentration of total glutathione decreased 24% ( P <0.05) at 3 h after endotoxin injection and 32% ( P <0.001) at 4 h...
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Clin Sci (Lond) (2009) 117 (8): 281–291.
Published: 24 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey Skeletal muscle dysfunction in COPD (chronic obstructive pulmonary disease) patients, particularly of the quadriceps, is of clinical interest because it not only influences the symptoms that limit exercise, but may also contribute...
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Clin Sci (Lond) (2009) 117 (7): 251–264.
Published: 17 August 2009
...William D.-C. Man; Paul Kemp; John Moxham; Michael I. Polkey COPD (chronic obstructive pulmonary disease), although primarily a disease of the lungs, exhibits secondary systemic manifestations. The skeletal muscles are of particular interest because their function (or dysfunction) not only...
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Clin Sci (Lond) (2007) 112 (8): 457–466.
Published: 13 March 2007
... uptake insulin muscle oxygen uptake restricted nutritive capacity skeletal muscle Muscle at rest is only partly perfused and, to accommodate the increase in metabolic demand for oxygen delivery in exercise, tissue perfusion is increased by capillary recruitment and total flow [ 1...
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Clin Sci (Lond) (2005) 108 (2): 159–165.
Published: 21 January 2005
..., skeletal muscle oxygenation was measured using a new Clark-type TC P O 2 [transcutaneous P O 2 (partial pressure of O 2 )]/ P CO 2 (partial pressure of CO 2 ) monitoring system and optical NIRS (near-infrared spectroscopy) at graded levels of hypoxaemia using a rabbit model ( n =6). The TC P O 2 / P CO 2...
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Clin Sci (Lond) (2004) 107 (6): 601–607.
Published: 24 November 2004
...). The other 20 patients were subjected to major abdominal surgery and were therefore scheduled to stay overnight in the recovery room during the first postoperative night (defined as major surgery). Protein FSRs (fractional synthesis rates) in skeletal muscle were determined during a measurement period of 90...
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Clin Sci (Lond) (2004) 106 (3): 241–249.
Published: 01 March 2004
... dehydrogenase complex (PDCa) in skeletal muscle. Ten patients with IC and peripheral arterial disease [ankle/brachial index (ABI)=0.73±0.13] and eight healthy controls (ABI=1.17±0.13) completed three maximal walking tests. From these tests, averaged estimates of walking time, peak V O 2 and the time constant...
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Clin Sci (Lond) (2003) 104 (3): 275–282.
Published: 14 February 2003
...U.B. FLÄRING; O.E. ROOYACKERS; J. WERNERMAN; F. HAMMARQVIST Glutathione is quantitatively the most important endogenous scavenger system. Glutathione depletion in skeletal muscle is pronounced following major trauma and sepsis in intensive care unit patients. Also, following elective surgery...
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Clin Sci (Lond) (2001) 100 (3): 283–290.
Published: 30 January 2001
...Andrew D. H. CLARK; Eugene J. BARRETT; Stephen RATTIGAN; Michelle G. WALLIS; Michael G. CLARK Insulin-mediated increases in limb blood flow are thought to enhance glucose uptake by skeletal muscle. Using the perfused rat hindlimb, we report that macro laser Doppler flowmetry (LDF) probes positioned...
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Clin Sci (Lond) (2000) 98 (5): 579–585.
Published: 05 April 2000
...C. J. DE RUITER; B. G. M. VAN ENGELEN; R. A. WEVERS; A. DE HAAN Myoadenylate deaminase (MAD) is an enzyme active in skeletal muscle, probably during exercise of moderate intensity but certainly during vigorous exercise, when the deamination of AMP leads to increased levels of IMP and ammonia...
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