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Keywords: Stroke
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Articles
Clin Sci (Lond) (2021) 135 (6): 753–773.
Published: 17 March 2021
...Karla B. Neves; Hannah E. Morris; Rhéure Alves-Lopes; Keith W. Muir; Fiona Moreton; Christian Delles; Augusto C. Montezano; Rhian M. Touyz Notch3 mutations cause Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), which predisposes to stroke and...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
...Sneha Raju; Jason E. Fish; Kathryn L. Howe Stroke is the leading cause of serious disability in the world and a large number of ischemic strokes are due to thromboembolism from unstable carotid artery atherosclerotic plaque. As it is difficult to predict plaque rupture and surgical treatment of...
Articles
Clin Sci (Lond) (2019) 133 (14): 1603–1607.
Published: 22 July 2019
...Sonu Bhaskar Diabetes is associated with poor recovery profiles following stroke. The pathophysiological mechanisms by which diabetes mediates neurological recovery after stroke are debatable. A recent paper published in the Clinical Science by Pintana et al. (Clinical Science (2019) 133 , 1367...
Articles
Clin Sci (Lond) (2019) 133 (13): 1367–1386.
Published: 01 July 2019
...Hiranya Pintana; Grazyna Lietzau; Ingrid Lovise Augestad; Fausto Chiazza; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes on...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1315–1328.
Published: 26 June 2018
...Emma L. Bailey; Martin W. McBride; John D. McClure; Wendy Beattie; Delyth Graham; Anna F. Dominiczak; Colin Smith; Joanna M. Wardlaw Background: The effect of salt on cerebral small vessel disease (SVD) is poorly understood. We assessed the effect of dietary salt on cerebral tissue of the stroke...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (10): 1055–1067.
Published: 25 May 2018
...Douglas M. Bennion; U. Muscha Steckelings; Colin Sumners Stroke is a devastating disease that afflicts millions of people each year worldwide. Ischemic stroke, which accounts for ~88% of cases, occurs when blood supply to the brain is decreased, often because of thromboembolism or atherosclerotic...
Articles
Clin Sci (Lond) (2018) 132 (10): 1021–1038.
Published: 25 May 2018
..., including cognition, memory, anxiety and depression, and several neurological disorders. Overactivity of the pressor axis of the RAS has been implicated in stroke and several brain disorders, such as cognitive impairment, dementia, and Alzheimer or Parkinson’s disease. The present review is focused on the...
Articles
Clin Sci (Lond) (2017) 131 (11): 1059–1068.
Published: 17 May 2017
... frequently present along with other age-related pathologies such as Alzheimer's disease (AD). Multiple etiology dementia with both VCI and AD is the single most common cause of later life dementia. There are two main clinical syndromes of VCI: post-stroke VCI in which cognitive impairment is the immediate...
Articles
Clin Sci (Lond) (2016) 130 (13): 1039–1050.
Published: 23 May 2016
... that cardiovascular-related comorbidities such as stroke contribute to morbidity and mortality in COPD. The mechanisms linking COPD and stroke remain to be fully defined but are likely to be interconnected. The association between COPD and stroke may be largely dependent on shared risk factors such as...
Articles
Clin Sci (Lond) (2016) 130 (4): 221–238.
Published: 14 January 2016
... neurovascular unit disorders including stroke and retinopathy. Moreover, the beneficial actions of RAS modulation in brain and retina have been documented in experimental research, but not yet exploited clinically. The RAS is a complex system with distinct yet interconnected components. Understanding the...
Articles
Clin Sci (Lond) (2014) 127 (2): 77–89.
Published: 17 March 2014
... miRNA expression following ischaemic stroke in an animal model. Adult (6 month) and middle-aged (11–12 months) female and male rats were subject to MCAo (middle cerebral artery occlusion) using ET-1 (endothelin-1). Circulating miRNAs were analysed in blood samples at 2 and 5 days post-stroke, and brain...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (5): 339–346.
Published: 25 October 2013
...Wen-Jun Tu; Sheng-Jie Zhao; Dong-Jiang Xu; Hui Chen Low vitamin D levels have been reported to contribute to the risk of cardiovascular events and mortality, especially stroke. In the present study we therefore evaluated the short-term prognostic value of serum 25(OH)D (25-hydroxyvitamin D) in...
Articles
Clin Sci (Lond) (2014) 126 (3): 195–205.
Published: 01 October 2013
...Robert W. Regenhardt; Douglas M. Bennion; Colin Sumners The goal of the present review is to examine the evidence for beneficial actions of manipulation of the RAS (renin–angiotensin system) in stroke, with particular focus on Ang-(1–7) [angiotensin-(1–7)] and its receptor Mas. The RAS appears to...
Articles
Clin Sci (Lond) (2012) 123 (3): 173–192.
Published: 12 April 2012
... stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases. Correspondence: Dr Ismail Laher (email ilaher@interchange.ubc.ca ). 9 12 2011 23 1 2012 31 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012...
Articles
Clin Sci (Lond) (2012) 122 (3): 105–111.
Published: 27 September 2011
... cell [ADMA and SDMA (symmetric dimethylarginine)]. In a recent study, elevation of SDMA was related to long-term mortality in patients recruited 30 days after a stroke event. In the present study, we aimed at investigating the association of SDMA and adverse clinical outcome in the early phase (first...
Articles
Clin Sci (Lond) (2010) 118 (6): 375–389.
Published: 15 December 2009
...Hilary V.O. Carswell; I. Mhairi Macrae; Tracy D. Farr Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models. However, a recent clinical trial indicated that HRT (hormone-replacement therapy...
Articles
Clin Sci (Lond) (2010) 118 (3): 183–185.
Published: 26 October 2009
...Simona Sacco; Antonio Carolei After a long debate, due to conflicting data from clinical studies, homocysteine is now largely accepted as a risk factor for cardiovascular diseases including stroke. To date, the role of elevated homocysteine levels in stroke recurrences has not been evaluated. In...
Articles
Clin Sci (Lond) (2010) 118 (3): 187–194.
Published: 26 October 2009
...Weili Zhang; Kai Sun; Jinxing Chen; Yuhua Liao; Qin Qin; Aiqun Ma; Daowen Wang; Zhiming Zhu; Yibo Wang; Rutai Hui Plasma homocysteine concentrations have been associated with the risk of stroke, but its relevance to secondary vascular events and mortality after stroke remains unclear because of...
Articles
Clin Sci (Lond) (2010) 118 (2): 147–157.
Published: 19 October 2009
... investigated in stroke. Therefore, in the present study, circulating mDCPs (myeloid DC precursors), pDCPs (plasmacytoid DCPs) and tDCPs (total DCPs) were analysed by flow cytometry in (i) healthy controls ( n =29), (ii) patients with ACI-S (asymptomatic cerebral infarction stenosis; n =46), (iii) patients with...
Articles
Clin Sci (Lond) (2009) 117 (11): 387–395.
Published: 14 September 2009
... stroke susceptibility. To test our hypothesis, we investigated the association of variants in the promoter of ANGPT2 with stroke in a multi-centre case-control study. We found that the C allele of rs3739390 conferred a 1.42-fold risk of lacunar infarction {adjusted OR (odds ratio), 1.42 [95% CI...
Articles
Clin Sci (Lond) (2009) 117 (7): 273–279.
Published: 17 August 2009
...-tagging SNP (single nucleotide polymorphism) approach to identify tag SNPs in DDAH2 . The SNPs were genotyped in 1603 stroke patients and 1525 control subjects. The study was replicated in another independent case-control study including 322 stroke patients and 891 control subjects. A promoter variant...
Articles
Clin Sci (Lond) (2009) 116 (10): 781–789.
Published: 15 April 2009
...Antonio Pinto; Antonino Tuttolomondo; Alessandra Casuccio; Domenico Di Raimondo; Riccardo Di Sciacca; Valentina Arnao; Giuseppe Licata The aim of the present study was to determine the rates of stroke in patients with chronic NVAF (non-valvular atrial fibrillation), evaluating the relationship...
Articles
Clin Sci (Lond) (2008) 115 (1): 25–33.
Published: 02 June 2008
... lupus erythematosous, two diseases with an increased risk of thrombotic events, as well as in ACS (acute coronary syndrome). OxLDL levels are also elevated in these diseases. Whether anti-(apoA-1) IgGs exist in other prothrombotic conditions, such as APE (acute pulmonary embolism) and stroke, has not...
Articles
Clin Sci (Lond) (2008) 114 (10): 651–659.
Published: 14 April 2008
... development of stroke in SHRs. The present study also demonstrates some unusual findings regarding the current understanding of the NO/O 2 − balance in hypertension with important differences between vascular beds and draws attention to the complexity of this balance in cardiovascular health and disease...
Articles
Clin Sci (Lond) (2008) 114 (1): 37–47.
Published: 30 November 2007
...Jessica M. Osmond; Christine' S. Rigsby; Anne M. Dorrance In recent years, it has become increasingly clear that the extra-renal effects of aldosterone play an important role in the pathogenesis of cardiovascular disease. Stroke is one of the leading causes of death in the Western world, and MR...
Articles
Clin Sci (Lond) (2004) 107 (5): 477–484.
Published: 26 October 2004
...Rajesh ULLEGADDI; Hilary J. POWERS; Salah E. GARIBALLA Evidence shows that there is a rapid increase in the production of markers of oxidative damage immediately following acute stroke and that endogenous antioxidant defences are rapidly depleted, thus permitting further tissue damage. Several...
Articles
Clin Sci (Lond) (2004) 107 (1): 27–28.
Published: 23 June 2004
...Justin C. T. PEPPERELL Sleep apnoea is associated with increased cardiovascular risk. Sleep apnoea is common after stroke and associated with increased blood pressure variability as described by Turkington and co-workers in this issue of Clinical Science . Both sleep apnoea and blood pressure...
Articles
Clin Sci (Lond) (2004) 107 (1): 75–79.
Published: 23 June 2004
...Peter M. TURKINGTON; John BAMFORD; Peter WANKLYN; Mark W. ELLIOTT Approx. 60% of acute stroke patients have periods of significant UAO (upper airway obstruction) and this is associated with a worse outcome. UAO is associated with repeated fluctuation in BP (blood pressure) and increased BP...
Articles
Clin Sci (Lond) (2002) 103 (5): 467–473.
Published: 03 October 2002
...Barbara LANINI; Francesco GIGLIOTTI; Claudia COLI; Roberto BIANCHI; Assunta PIZZI; Isabella ROMAGNOLI; Michela GRAZZINI; Loredana STENDARDI; Giorgio SCANO Dyspnoea is not a prominent complaint of resting patients with recent hemispheric stroke (RHS). We hypothesized that, in patients with RHS...
Articles
Clin Sci (Lond) (1997) 93 (5): 401–411.
Published: 01 November 1997
...Giuseppe Biagini; Michele Zoli; Carla Torn; Sabina Boschi; Giuseppe Vantaggiato; Marco Ballestri; Alberto Baraldi; Luigi F. Agnati 1. Stroke-prone spontaneously hypertensive rats (SHRsp) have been used widely to test agents putatively capable of vascular protection. These animals present an...
Articles
Clin Sci (Lond) (1996) 91 (4): 399–413.
Published: 01 October 1996
...-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor treatment, comprising 2.4% (2.0 to 2.7) with a history of myocardial infarction, 1.9% (1.6 to 2.2) with angina and 0.5% (0.3–0.7) with a history of stroke-all with total cholesterol >5.5 mmol/l. The prevalence of these diagnoses with total...
Articles
Clin Sci (Lond) (1995) 89 (3): 247–253.
Published: 01 September 1995
... aortic compliance is abnormal in patients with stroke. 2. Pulse wave velocity measurements of thoracoabdominal aortic compliance were made in 20 stroke patients and 25 age- and sex-matched hospitalized, non-stroke control subjects putatively free of cardiovascular disease. Since compliance varies with...
Articles
Clin Sci (Lond) (1991) 81 (3): 335–340.
Published: 01 September 1991
...John S. Smeda; Olexa Tkachenko 1. Previous studies have indicated that increases in dietary K + promote diuresis and retard stroke development in stroke-prone spontaneously hypertensive rats (spSHR) fed a Japanese-style diet containing 4% NaCl. 2. It is possible that elevations in dietary K...
Articles
Clin Sci (Lond) (1981) 61 (s7): 369s–371s.
Published: 01 December 1981
...Paul K. Whelton; Peter Goldblatt 1. Analysis of age-adjusted death rates from 21 countries over a 20-year period identified the presence of a strong positive association between recorded mortality from stroke, hypertension and stomach cancer. However, the slopes of regression lines for secular...
Articles
Clin Sci Mol Med (1976) 51 (s3): 673s–675s.
Published: 01 December 1976
... mortality was far higher in men than in women. 4. Causes of death were stroke in 17%, heart failure in 24%, coronary occlusion in 16%, uraemia in 4% and other diseases in 39%. At the first examination thirteen cases of malignant hypertension were registered, none at later sessions. © 1976 The Biochemical...
Articles
Clin Sci Mol Med (1976) 51 (s3): 45s–48s.
Published: 01 December 1976
... malignant nephrosclerosis stroke Clinical Science and Molecular Medicine (1976) 51, 45-8s. Vasopressin and malignant deoxycorticosterone hypertension in rats J . M O H R I N G , B. M O H R I N G , M. P E T R I AND D. H A A C K Department of Pharmacology, University of Heidelberg, Heidelberg, Germany...
Articles
Clin Sci Mol Med (1975) 48 (s2): 161s–163s.
Published: 01 January 1975
...K. Okamoto; F. Hazama; Y. Yamori; H. Haebara; A. Nagaoka 1. A colony of stroke-prone spontaneously hypertensive rats has been developed by selective breeding. 2. These animals developed severe hypertension early in life, the magnitude of the hypertension being closely related to the incidence of...
Articles
Clin Sci Mol Med (1975) 48 (s2): 127s–129s.
Published: 01 January 1975
... Biochemical Society and the Medical Research Society 1975 renin sodium stroke Clinical Science and Molecular Medicine (1975) 48, 127s-129s. Plasma renin, urinary sodium excretion and vascular disease A. E. DOYLE, K. G. C H U A , S. D U F F Y A N D W. J. L O U I S Dcpartmeiit of Medicine, Austin...
Articles
Clin Sci Mol Med (1973) 45 (s1): 205s–208s.
Published: 01 August 1973
... arteriosclerosis does not seem to be influenced to the same degree. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension hypotensive drugs stroke myocardial infarction Clinical Science and Molecular Medicine (1973) 45, 205s-208s. C O M P L I C A T I O N S I N T R E A T E...
Articles
Clin Sci Mol Med (1973) 45 (s1): 191s–193s.
Published: 01 August 1973
.... Since 1960 myocardial infarction, rather than cerebrovascular accident, has been the commonest cause of death. © 1994 The Biochemical Society and the Medical Research Society 1994 hypertension renal failure proteinuria stroke Clinical Science and Molecular Medicine (1973) 45, 191s-193s. T...