...Gian Luca Bagnato; Natasha Irrera; Gabriele Pizzino; Domenico Santoro; William Neal Roberts; Gianfilippo Bagnato; Giovanni Pallio; Mario Vaccaro; Francesco Squadrito; Antonino Saitta; Domenica Altavilla; Alessandra Bitto Systemic sclerosis (SSc) is a connective tissue disorder characterized...

...) and systemic sclerosis (SSc) produce low levels of prostaglandin (PG) E 2 , due to a limited capacity to up-regulate cyclooxygenase-2 (COX-2). This deficiency contributes functionally to the fibroproliferative state, however the mechanisms responsible are incompletely understood. In the present study, we...

... (systemic sclerosis). SSc is an autoimmune disorder in which vascular injury occurs and there is a chronic low-grade inflammation followed by excessive ECM (extracellular matrix) deposition and ultimately fibrosis. The fibrosis ultimately leads to organ dysfunction and death. The preceding vascular damage...

...Nicholas K. Harrison; Alison D. Cambrey; Allen R. Myers; Anne M. Southcott; Carol M. Black; Roland M. du Bois; Geoffrey J. Laurent; Robin J. McAnulty 1. Interstitial lung disease is a common complication of systemic sclerosis. The mechanism by which excess collagen is deposited in the lung...

...C. I. Westacott; J. T. Whicher; C. W. Hutton; P. A. Dieppe 1. Increased spontaneous production of interleukin-1, measured as lymphocyte-activating factor activity, was seen in unstimulated monocytes from systemic sclerosis patients. 2. Inhibitory activity to interleukin-1 was seen in both normal...

...Iren B. Kovacs; R. H. Meyrick Thomas; A. R. Mackay; M. H. A. Rustin; J. D. T. Kirby 1. Chemiluminescence (CL) of whole blood and isolated polymorphonuclear leucocytes (PMN) from patients with systemic sclerosis (SS) and from age and sex matched controls was measured. CL was induced by the addition...

...Y. M. Traub; A. P. Shapiro; T. A. Osial, Jr; G. P. Rodnan; T. A. Medsger; D. E. Leb; W. C. Christy 1. Renal involvement in progressive systemic sclerosis is characterized by hypertension, grade III or IV hypertensive retinopathy, rapidly progressive renal failure and enhanced plasma renin activity...