... were attenuated in Redd1 −/− mice. Mechanistically, REDD1 in GECs regulated CXCL1 production, which attracted MHCII + monocytes migration by CXCL1-CXCR2 axis. Then H. pylori induced MHCII + monocytes to secrete IL-23, which favored IL-17A-producing CD4 + cell (Th17 cell) polarization, thereby...

...Bo Pang; Yu Zhen; Cong Hu; Zhanchuan Ma; Shan Lin; Huanfa Yi Immune cells play important roles in systemic lupus erythematosus (SLE). We previously found that myeloid-derived suppressor cell (MDSC)-derived arginase-1 (Arg-1) promoted Th17 cell differentiation in SLE. In the present study, we...

... and in vitro mixed culture system. Microglia overexpressing CD200R produced less inflammatory chemokines and reduced the loss of TH + neurons. In addition, HMGB1 A box decreased the level of CCL5 and significantly inhibited the infiltration of almost all T cells including Th17 and the proportion of Th17 in CD4...

... lead to IL-1β (interleukin 1β) expression in diseased MRL/ lpr mice and high-disease-activity SLE patients. Previous study has revealed that MDSCs could alter the plasticity of Th17 (T helper 17) cells and Tregs (regulatory T-cells) via ROS and IL-1β. Co-culture experiments showed that G-MDSCs impaired...

... effect reported in patients with recurrent miscarriage. However, studies on maternal peripheral blood are conflicting. In the present study, we characterized the maternal CD4 T-cell effector subsets, including the recently described Th17 subset, during normal pregnancy (cross-sectional cohort, n =71...