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Keywords: Therapeutic Drug Monitoring
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Articles
MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S -adenosylmethionine and de novo purine synthesis
Available to PurchaseYi-Cheng Wang, Ming-Tsung Wu, Feng-Yao Tang, Der-Yuan Chen, Hsin-An Ko, Barry Shane, Wen-Nan Huang, En-Pei Isabel Chiang
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 253–267.
Published: 25 January 2019
... Therapeutic Drug Monitoring Folate-mediated 1-carbon metabolism has been the target of many therapies in diseases involving cell proliferation. Low-dose methotrexate (MTX) is one of the most commonly used immunosuppressants in treating rheumatoid arthritis (RA) in humans. Methylenetetrahydrofolate...
