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Keywords: Toll-like receptor
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Clin Sci (Lond) (2014) 127 (6): 375–390.
Published: 29 May 2014
... TLR2 (Toll-like receptor 2), MyD88 (myeloid differentiation factor 88) and PI3K (phosphoinositide 3-kinase) complex formation. S. aureus stimulated Akt, JNK1/2 (c-Jun N-terminal kinase 1/2) and p42/p44 MAPK (mitogen-activated protein kinase) phosphorylation, which were inhibited by resveratrol...
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Clin Sci (Lond) (2014) 126 (5): 329–337.
Published: 25 October 2013
... system interleukin-6 myeloid differentiation factor 88 (MyD88) systemic sclerosis Toll-like receptor tumour-necrosis-factor-receptor-associated factor (TRAF) The innate immune system has evolved to protect us from invading organisms and from ‘danger’ elicited by ‘danger signals’ mediated via...
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Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
.... Evidence from experimental animal models as well as humans has indicated that systemic inflammation plays a role in the pathophysiological processes of diabetes and is facilitated by innate immune responses. TLRs (Toll-like receptors) are key innate immune receptors that recognize conserved PAMPs (pathogen...
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Clin Sci (Lond) (2011) 121 (10): 415–426.
Published: 25 July 2011
...Ruth Broering; Mengji Lu; Joerg F. Schlaak TLRs (Toll-like receptors), as evolutionarily conserved germline-encoded pattern recognition receptors, have a crucial role in early host defence by recognizing so-called PAMPs (pathogen-associated molecular patterns) and may serve as an important link...
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Clin Sci (Lond) (2005) 109 (2): 125–133.
Published: 25 July 2005
...Nazia Chaudhuri; Steven K. Dower; Moira K. B. Whyte; Ian Sabroe TLRs (Toll-like receptors) comprise a family of proteins whose function is principally to facilitate the detection of, and response to, pathogens. Protozoa, helminths, viruses, bacteria and fungi can all activate TLR signalling...