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Keywords: Toll-like receptor
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Clin Sci (Lond) (2014) 127 (6): 375–390.
Published: 29 May 2014
... -induced TLR2 (Toll-like receptor 2), MyD88 (myeloid differentiation factor 88) and PI3K (phosphoinositide 3-kinase) complex formation. S. aureus stimulated Akt, JNK1/2 (c-Jun N-terminal kinase 1/2) and p42/p44 MAPK (mitogen-activated protein kinase) phosphorylation, which were inhibited by resveratrol. In...
Clin Sci (Lond) (2014) 126 (5): 329–337.
Published: 25 October 2013
... immune dysregulation in SSc and that this aberrant immune response leads to activation of the key effector cell; the fibroblast. TLRs (Toll-like receptors) are germ-line-encoded PRRs (pattern recognition receptors) that have evolved to recognize components of pathogens and also endogenous danger signals...
Clin Sci (Lond) (2013) 125 (1): 19–25.
Published: 13 March 2013
... © 2013 Biochemical Society 2013 developmental programming metabolic syndrome oxidative stress pro-inflammation Toll-like receptor Improving maternal health was recently recognized at the United Nations High-level Meeting on Non-communicable Diseases as an important strategy in...
Clin Sci (Lond) (2012) 122 (11): 527–533.
Published: 10 February 2012
...Ellen H. A. M. Elsenberg; Dik Versteeg; Jan-Willem Sels; Pieter-Jan J. Vlaar; Monique G. G. Hobbelink; Maarten-Jan M. Cramer; Dominique P. V. de Kleijn; René A. Tio; Bart J. G. L. de Smet; Pieter A. Doevendans; Imo E. Hoefer; Gerard Pasterkamp TLR (Toll-like receptor) activation-induced...
Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
.... Evidence from experimental animal models as well as humans has indicated that systemic inflammation plays a role in the pathophysiological processes of diabetes and is facilitated by innate immune responses. TLRs (Toll-like receptors) are key innate immune receptors that recognize conserved PAMPs (pathogen...
Clin Sci (Lond) (2011) 121 (10): 415–426.
Published: 25 July 2011
...Ruth Broering; Mengji Lu; Joerg F. Schlaak TLRs (Toll-like receptors), as evolutionarily conserved germline-encoded pattern recognition receptors, have a crucial role in early host defence by recognizing so-called PAMPs (pathogen-associated molecular patterns) and may serve as an important link...
Clin Sci (Lond) (2011) 121 (9): 367–387.
Published: 12 July 2011
...Mark L. Hanke; Tammy Kielian The discovery of mammalian TLRs (Toll-like receptors), first identified in 1997 based on their homology with Drosophila Toll, greatly altered our understanding of how the innate immune system recognizes and responds to diverse microbial pathogens. TLRs are...
Clin Sci (Lond) (2011) 120 (9): 415–426.
Published: 18 January 2011
... cells) and pDCs (plasmacytoid dendritic cells) were analysed by multicolour flow cytometry in fresh blood, and after overnight incubation with TLR (Toll-like receptor)-4 or -7 ligands LPS (lipopolysaccharide) or IQ (imiquimod). DC function was measured by IL (interleukin)-12 and IFN (interferon)-α...
Clin Sci (Lond) (2005) 109 (2): 125–133.
Published: 25 July 2005
...Nazia Chaudhuri; Steven K. Dower; Moira K. B. Whyte; Ian Sabroe TLRs (Toll-like receptors) comprise a family of proteins whose function is principally to facilitate the detection of, and response to, pathogens. Protozoa, helminths, viruses, bacteria and fungi can all activate TLR signalling, and...