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Keywords: Toll-like receptor 9
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Articles
Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 429–435.
Published: 07 June 2012
...) that acts via TLR9 (Toll-like receptor 9), a pattern recognition receptor of the immune system which detects bacterial and viral DNA but not vertebrate DNA. The ability of mtDNA to activate TLR9 in a similar fashion to bacterial DNA stems from evolutionarily conserved similarities between bacteria...
