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Keywords: Type 1 diabetesClose
Mariana Rodrigues Davanso, Amanda Rabello Crisma, Tárcio Teodoro Braga, Laureane Nunes Masi, Cátia Lira do Amaral, Vinícius Nunes Cordeiro Leal, Dhêmerson Souza de Lima, Thiago Andrade Patente, José Alexandre Barbuto, Maria L. Corrêa-Giannella, Mario Lauterbach, Carl Christian Kolbe, Eicke Latz, Niels Olsen Saraiva Camara, Alessandra Pontillo, Rui Curi
Clin Sci (Lond) (2021) 135 (1): 19–34.
Published: 05 January 2021
...; Niels Olsen Saraiva Camara; Alessandra Pontillo; Rui Curi Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by insulin-producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like receptor family-pyrin domain containing 3 (NLRP3) are associated...
Includes: Supplementary data
Ahmed A. Arzouni, Andreia Vargas-Seymour, Chloe L. Rackham, Paramjeet Dhadda, Guo-Cai Huang, Pratik Choudhary, Nance Nardi, Aileen J.F. King, Peter M. Jones
Clin Sci (Lond) (2017) 131 (23): 2835–2845.
Published: 28 November 2017
.... Furthermore, we demonstrate that these beneficial effects on islet function can be partly attributed to the MSC-derived products ECM and ANXA1. Conclusions: Our results suggest that hASCs have the potential to improve the quality of human islets isolated for transplantation therapy of Type 1 diabetes...
Includes: Supplementary data
Dorinne Desposito, Catherine Chollet, Christopher Taveau, Vincent Descamps, François Alhenc-Gelas, Ronan Roussel, Nadine Bouby, Ludovic Waeckel
Clin Sci (Lond) (2016) 130 (1): 45–56.
Published: 30 November 2015
... receptors kallikrein–kinin system skin wound healing Type 1 diabetes Type 2 diabetes • Impairment of skin wound repair is a major complication of diabetes, favouring development of foot ulcers and contributing to their poor prognosis. Improving skin healing is a therapeutic issue in diabetic...
Mauricio Krause, Kevin Keane, Josianne Rodrigues-Krause, Domenico Crognale, Brendan Egan, Giuseppe De Vito, Colin Murphy, Philip Newsholme
Clin Sci (Lond) (2014) 126 (10): 739–752.
Published: 03 February 2014
... provoke β-cell dysfunction and thus is potentially an important mediator of β-cell failure. aging extracellular heat-shock protein 72 (eHSP72) insulin resistance pancreatic β-cell Type 1 diabetes Type 2 diabetes The clonal insulin-secreting β-cell lines BRIN-BD11 and 1.1B4 were chosen...
Chris Tikellis, Raelene J. Pickering, Despina Tsorotes, Valma Harjutsalo, Lena Thorn, Aila Ahola, Johan Wadén, Nina Tolonen, Markku Saraheimo, Daniel Gordin, Carol Forsblom, Per-Henrik Groop, Mark E. Cooper, John Moran, Merlin C. Thomas
Clin Sci (Lond) (2013) 124 (10): 617–626.
Published: 04 February 2013
... of atherogenesis were assessed using RT–PCR (reverse transcription–PCR) and ELISA. The association of sodium intake and adverse cardiovascular and mortality outcomes were explored in 2648 adults with Type 1 diabetes without prior CVD (cardiovascular disease) from the FinnDiane study. A 0.05% sodium diet...
Clin Sci (Lond) (2010) 118 (2): 87–97.
Published: 12 October 2009
...Michael D. McCall; Christian Toso; Emmanuel E. Baetge; A. M. James Shapiro With the already heightened demand placed on organ donation, stem cell therapy has become a tantalizing idea to provide glucose-responsive insulin-producing cells to Type 1 diabetic patients as an alternative to islet...
Clin Sci (Lond) (2009) 116 (7): 565–574.
Published: 02 March 2009
... transcription and altered cell phenotype. In diabetic animals and Type 1 diabetic patients, short-term studies indicate that C-peptide also enhances glucose disposal and metabolic control. Furthermore, results derived from animal models and clinical studies in Type 1 diabetic patients suggest a salutary effect...
Clin Sci (Lond) (2008) 115 (12): 361–369.
Published: 12 November 2008
... the effect of acute variations in plasma glucose and insulin on plasma ADMA levels in young people with T1D (Type 1 diabetes). Fifteen young patients (ten males) with T1D, median age 18.3 (13.2–24.4) years, HbA 1c (glycated haemoglobin) 9% (6.4–13.6%), underwent an overnight (18:00–08:00 hours) variable...
Thomas Forst, Andreas Pfützner, Thomas Kunt, Thomas Pohlmann, Ulrike Schenk, Rupert Bauersachs, Ernst Küstner, Jürgen Beyer
Clin Sci (Lond) (1998) 94 (3): 255–261.
Published: 01 March 1998
... in Type 1 diabetes patients with neuropathy. 4. The ratio between capillary blood flow and total skin perfusion decreased significantly in the control group (from 0.82 ± 0.15 to 0.47 ± 0.11; P < 0.005) and in the Type I diabetes patients without neuropathy (from 0.79 ± 0.12 to 0.43 ± 0.12; P < 0.05...
J. Komulainen, M. Knip, E. Sabbah, P. Vähäsalo, R. Lounamaa, H. K. Åkerblom, H. Reijonen, J. Ilonen, Childhood Diabetes in Finland Study Group
Clin Sci (Lond) (1998) 94 (3): 263–269.
Published: 01 March 1998
... of the beta-cell destructive process leading to clinical Type I diabetes. 20 11 1997 26 11 1997 © 1998 The Biochemical Society and the Medical Research Society 1998 autoantibodies clinical characteristics genetic susceptibility Type 1 diabetes Clinical Science (1998) 94,263-269...
Clin Sci (Lond) (1989) 76 (6): 603–607.
Published: 01 June 1989
... resulting in increased platelet aggregation. 2 9 1988 12 10 1988 © 1989 The Biochemical Society and the Medical Research Society 1989 noradrenaline efflux platelet type 1 diabetes Clinical Science (1989) 76, 603-607 603 Platelet efflux of noradrenaline in patients with type 1...
Clin Sci (Lond) (1987) 72 (1): 123–130.
Published: 01 January 1987
...J. Kastrup; T. Nørgaard; H.-H. Parving; N. A. Lassen 1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without...