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Keywords: Type 2 diabetes
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Articles
Clin Sci (Lond) (2021) 135 (4): 593–595.
Published: 18 February 2021
... fluid and neurological recovery after subarachnoid hemorrhage . Stroke 48 , 2231 – 2237 10.1161/STROKEAHA.117.017758 28663512 © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 cognition hippocampus mitochondria Platelets type 2...
Articles
Clin Sci (Lond) (2021) 135 (3): 589–591.
Published: 10 February 2021
... 2021 cardiovascular disease Metabolites type 2 diabetes Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and defect in metabolism of energy substrate—carbohydrate, fat and protein [ 1 ]. Most organs and systems are affected including brain, heart, kidney, eyes...
Articles
Clin Sci (Lond) (2020) 134 (17): 2369–2379.
Published: 16 September 2020
...Joshua A. Beckman; Jiun-Ruey Hu; Shi Huang; Eric Farber-Eger; Quinn S. Wells; Thomas J. Wang; Robert E. Gerszten; Jane F. Ferguson Objective: Type 2 diabetes mellitus (T2DM) reduces exercise capacity, but the mechanisms are incompletely understood. We probed the impact of ischemic stress...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (17): 2337–2352.
Published: 10 September 2020
... studies have shown that TRAIL delivery ameliorated glucose control in type 1 and type 2 diabetes. It is currently unknown whether TRAIL positive effects are maintained in more severe forms of type 2 diabetes, and whether they include renoprotection. Our study aimed at evaluating TRAIL effects in a severe...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (16): 2161–2175.
Published: 24 August 2020
... 2020 cognitive impairment hippocampus mitochondrial transplantation oxidative stress platelet type 2 diabetes The global convergence of lifestyle variation and population aging has resulted in the increased incidence of diabetes [ 1 ]. According to epidemiological analysis, the number...
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Clin Sci (Lond) (2020) 134 (5): 529–542.
Published: 13 March 2020
...Jizheng Chen; Fang Wang; Yue Zhou; Jing Jiang; Sulaiman Ksimu; Xu Zhang; John Zhong Li; Junqi Niu; Qian Wang Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (5): 547–570.
Published: 13 March 2020
... play a role in inflammation. In this review, we try to elucidate the connections between peripheral inflammation at obesity and Type 2 diabetes and the central inflammatory process. Multiple lines of evidence highlight the importance of peripheral inflammation and its link to neuroinflammation, which...
Articles
Clin Sci (Lond) (2019) 133 (22): 2317–2327.
Published: 26 November 2019
...Nicolás Gómez-Banoy; James C. Lo The growing prevalence of obesity and its related metabolic diseases, mainly Type 2 diabetes (T2D), has increased the interest in adipose tissue (AT) and its role as a principal metabolic orchestrator. Two decades of research have now shown that ATs act...
Articles
Clin Sci (Lond) (2019) 133 (21): 2121–2141.
Published: 06 November 2019
... ( phillip.kantharidis@monash.edu ) 12 07 2019 07 10 2019 08 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease diabetic nephropathy inflammation therapeutics type 2 diabetes Historically, diabetes...
Articles
Clin Sci (Lond) (2019) 133 (19): 2029–2044.
Published: 14 October 2019
... Correspondence: Po Sing Leung ( psleung@cuhk.edu.hk ) Apoptosis CVX343 Insulin Islets Obesity Type 2 diabetes Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and hyperlipidemia. Most patients with T2DM are overweight or obese, and thus the global...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (15): 1705–1720.
Published: 02 August 2019
...Mei Xue; Ting Li; Yue Wang; Yunpeng Chang; Ying Cheng; Yunhong Lu; Xiangyang Liu; Linxin Xu; Xiaoyu Li; Xiaochen Yu; Bei Sun; Liming Chen Cardiovascular complications contribute to the major mortality and morbidity in type 2 diabetes. Diabetic cardiomyopathy (DCM) is increasingly recognized...
Includes: Supplementary data
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Clin Sci (Lond) (2019) 133 (13): 1367–1386.
Published: 01 July 2019
...Hiranya Pintana; Grazyna Lietzau; Ingrid Lovise Augestad; Fausto Chiazza; Thomas Nyström; Cesare Patrone; Vladimer Darsalia Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes...
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Clin Sci (Lond) (2018) 132 (22): 2451–2467.
Published: 30 November 2018
... Limited on behalf of the Biochemical Society 2018 exosomes Insulin sensitivity microRNA pregnancy type 2 diabetes Maternal metabolism undergoes dynamic changes in pregnancy to ensure an adequate supply of metabolites for the growth and development of the fetus. This involves an increase...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (20): 2207–2220.
Published: 23 October 2018
...Sara Baqar; Dorothy Liu; Lisa F. Lincz; Yee Wen Kong; George Jerums; Elif I. Ekinci Objective: Low sodium intake is paradoxically associated with adverse cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2D), possibly from renin–angiotensin–aldosterone system (RAAS) activation...
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Clin Sci (Lond) (2018) 132 (15): 1699–1709.
Published: 16 August 2018
...James G. Boyle; Rachel Livingstone; John R. Petrie Type 2 diabetes (T2D) carries risks of both cardiovascular (CV) (myocardial infarction, stroke, and peripheral vascular disease) and microvascular (retinopathy/nephropathy/neuropathy) complications. Glucose-lowering is an effective strategy...
Articles
Clin Sci (Lond) (2018) 132 (15): 1629–1643.
Published: 14 August 2018
... pluripotent stem cells type 2 diabetes Wound healing Diabetes mellitus is a major global health concern, affecting approximately 425 million adults worldwide, a figure predicted to rise to 629 million people with diabetes by 2045 (International Diabetes Federation). Type 1 diabetes mellitus (T1DM...
Articles
Clin Sci (Lond) (2018) 132 (10): 1039–1054.
Published: 25 May 2018
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 brown adipose tissue beige adipose tissue insulin resistance obesity type 2 diabetes Since the re-discovery and definitive identification of functional brown adipose tissue (BAT) in adult humans...
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Clin Sci (Lond) (2018) 132 (4): 489–507.
Published: 28 February 2018
...Keizo Kanasaki Emerging evidence suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors used to treat type 2 diabetes may have nephroprotective effects beyond the reduced renal risk conferred by glycemic control. DPP-4 is a ubiquitous protein with exopeptidase activity that exists in cell membrane...
Articles
Clin Sci (Lond) (2018) 132 (2): 213–229.
Published: 19 January 2018
... protein 1 (Ninj1) is an adhesion molecule that not only contributes to inflammation but also regulates the apoptosis of endothelial cells. In the present study, Ninj1 was found highly expressed in endothelial cells in Type 2 diabetic mice and increased in high-glucose (HG) cultured HUVECs. Furthermore, we...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (1): 69–83.
Published: 05 January 2018
... diabetes. It has been shown that TRAIL deficiency worsens diabetes and that TRAIL delivery, when it is given before disease onset, slows down its development. The present study aimed at evaluating whether TRAIL had the potential not only to prevent, but also to treat type 2 diabetes. Thirty male C57BL/6J...
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Clin Sci (Lond) (2017) 131 (15): 1905–1917.
Published: 07 July 2017
...Bram Brouwers; Vera B. Schrauwen-Hinderling; Tomas Jelenik; Anne Gemmink; Bas Havekes; Yvonne Bruls; Dennis Dahlmans; Michael Roden; Matthijs K.C. Hesselink; Patrick Schrauwen Non-alcoholic fatty liver (NAFL) is an independent risk factor for the development of type 2 diabetes (T2DM). We examined...
Articles
Clin Sci (Lond) (2017) 131 (10): 991–1000.
Published: 09 May 2017
...Ashish Patidar; Dhruv K. Singh; Shori Thakur; Peter Winocour; Ken Farrington; Anwar R. Baydoun Although vascular calcification (VC) is prevalent in Type 2 diabetes mellitus (T2DM), underlying mechanisms remain unclear. Neither is it known whether T2DM confers calcific potential (CP) on serum...
Articles
Clin Sci (Lond) (2017) 131 (5): 343–353.
Published: 15 February 2017
... AT that expresses the GLP-1 receptor (GLP-1R). The present study aimed to assess the impact of GLP-1 analogue treatment on subcutaneous AT (SCAT) inflammatory and fibrotic responses, compared with weight loss by calorie reduction (control). Among the 39 participants with Type 2 diabetes recruited, 30 age-matched...
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Clin Sci (Lond) (2017) 131 (1): 37–47.
Published: 09 December 2016
...Rikke Kruse; Andreas J.T. Pedersen; Jonas M. Kristensen; Stine J. Petersson; Jørgen F.P. Wojtaszewski; Kurt Højlund Type 2 diabetes (T2D) is characterized by insulin resistance, mitochondrial dysregulation and, in some studies, exercise resistance in skeletal muscle. Regulation of autophagy...
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Clin Sci (Lond) (2016) 130 (1): 45–56.
Published: 30 November 2015
... models of diabetes. bradykinin receptors kallikrein–kinin system skin wound healing Type 1 diabetes Type 2 diabetes Correspondence: Dr Nadine Bouby (email nadine.bouby@crc.jussieu.fr ). 20 4 2015 14 9 2015 6 10 2015 6 10 2015 • Impairment of skin...
Articles
Clin Sci (Lond) (2015) 129 (5): 415–422.
Published: 11 June 2015
... aldosterone level and estimated glomerular filtration rate (eGFR) in hypertensive patients with type 2 diabetes. In a randomized, double-blind, placebo-controlled study (RCT), 28 patients with type 2 diabetes, treated with telmisartan (40 mg daily), received 2 weeks of placebo or NaCl capsules (100 mmol/24 h...
Articles
Clin Sci (Lond) (2015) 128 (10): 707–713.
Published: 27 February 2015
...Mavin Macauley; Fiona E Smith; Peter E Thelwall; Kieren G Hollingsworth; Roy Taylor Storage of food-derived glucose as muscle and liver glycogen is vital to avoid damaging swings plasma osmolarity. We report that in Type 2 diabetes, muscle glycogen storage was completely inactive although liver...
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Clin Sci (Lond) (2015) 128 (7): 405–410.
Published: 09 December 2014
...Roy Taylor; Rury R. Holman Type 2 diabetes (T2DM) is frequently regarded as a disease of obesity and its occurrence in individuals of normal body mass index (BMI) is often regarded as indicating a non-obesity-related subtype. However, the evidence for such a distinct, common subtype is lacking...
Articles
Clin Sci (Lond) (2015) 128 (7): 411–423.
Published: 09 December 2014
... (db/db) mice, a model of Type 2 diabetes and control Lepr db /Lepr + (db/+) mice were administered atorvastatin (10 mg/kg per day, 2 weeks). Atorvastatin improved glucose tolerance in db/db mice. Systemic and vascular oxidative stress in db/db mice, characterized by increased plasma TBARS...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (12): 665–677.
Published: 08 August 2014
... Boscá; María Fernández-Velasco Type 2 diabetes has a complex pathology that involves a chronic inflammatory state. Emerging evidence suggests a link between the innate immune system receptor NOD1 (nucleotide-binding and oligomerization domain 1) and the pathogenesis of diabetes, in monocytes and hepatic...
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Clin Sci (Lond) (2014) 127 (2): 91–100.
Published: 17 March 2014
... of the present study was to investigate the role of GdCl 3 in hepatic gluconeogenesis and explore the precise molecular mechanism. Animals from a classical Type 2 diabetic mouse model, created by exposing C57BL/6J mice to a high-fat diet for 4 months, were treated with GdCl 3 or saline. Body weight, blood...
Articles
Clin Sci (Lond) (2014) 126 (10): 739–752.
Published: 03 February 2014
... of β-cell failure. aging extracellular heat-shock protein 72 (eHSP72) insulin resistance pancreatic β-cell Type 1 diabetes Type 2 diabetes • eHSP72 is increased in the plasma of both types of diabetes and is positively correlated with inflammatory markers; however, no studies have...
Articles
Clin Sci (Lond) (2013) 125 (8): 383–389.
Published: 14 June 2013
...Pam R. Taub; Israel Ramirez-Sanchez; Theodore P. Ciaraldi; Silvia Gonzalez-Basurto; Ramon Coral-Vazquez; Guy Perkins; Michael Hogan; Alan S. Maisel; Robert R. Henry; Guillermo Ceballos; Francisco Villarreal HF (heart failure) and T2D (Type 2 diabetes) associate with detrimental alterations in SkM...
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Clin Sci (Lond) (2013) 125 (6): 301–310.
Published: 22 May 2013
... countries and share multiple risk factors. The relationship between NAFLD and AF in Type 2 diabetes is currently unknown. We studied a hospital-based sample of 702 patients with Type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. The diagnosis of AF was confirmed in affected...
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Clin Sci (Lond) (2013) 125 (4): 167–182.
Published: 26 April 2013
...Karen E. Porter; Kirsten Riches The rising epidemic of T2DM (Type 2 diabetes mellitus) worldwide is of significant concern. The inherently silent nature of the disease in its early stages precludes early detection; hence cardiovascular disease is often established by the time diabetes is diagnosed...
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Clin Sci (Lond) (2012) 123 (6): 375–386.
Published: 29 May 2012
... in their controls, but the total PP1α protein level was not different. These results suggest that the aortic relaxation responses, NO production, and eNOS activity mediated by CaMKII phosphorylation are decreased in this Type 2 diabetic model, and that these impairments of CaMKII signalling may be, at least in part...
Articles
Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
...-line oral therapy for T2D (Type 2 diabetes). The main effect of this drug from the biguanide family is to acutely decrease hepatic glucose production, mostly through a mild and transient inhibition of the mitochondrial respiratory chain complex I. In addition, the resulting decrease in hepatic energy...
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Clin Sci (Lond) (2012) 122 (5): 203–214.
Published: 28 October 2011
... 2012 Biochemical Society 2012 hyperglycaemia inflammation insulin resistance oxidative stress Toll-like receptor Type 2 diabetes Diabetes affects more than 348 million people worldwide and around 36 million in the U.S.A. [ 1 , 2 ]. The prevalence of diabetes is increasing...
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Clin Sci (Lond) (2011) 121 (4): 169–177.
Published: 04 May 2011
..., but no direct measurement has tested this concept or its possible relationship to the reported impairment in insulin-stimulated muscle ATP production. Isoglycaemic–hyperinsulinaemic clamps with [ 13 C]glucose infusion were performed on Type 2 diabetic subjects and matched controls with measurement of glycogen...
Articles
Clin Sci (Lond) (2011) 120 (10): 463–472.
Published: 28 January 2011
...Adriana Georgescu; Doina Popov; Anamaria Constantin; Miruna Nemecz; Nicoleta Alexandru; Daniel Cochior; Aura Tudor The aim of the present study was to examine the effects of obesity alone and obesity associated with Type 2 diabetes on the structure, vascular reactivity and response to insulin...
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Clin Sci (Lond) (2010) 119 (7): 293–301.
Published: 25 June 2010
... function statin Type 2 diabetes Hyperlipidaemia and hyperglycaemia are frequently reported in obese subjects and are highly associated with the development of cardiovascular disorders, the primary cause of death in obesity. Whereas treatment with HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase...
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Clin Sci (Lond) (2010) 118 (10): 607–615.
Published: 23 February 2010
...Sandra J. Hamilton; Gerard T. Chew; Timothy M.E. Davis; Gerald F. Watts Dyslipidaemia contributes to endothelial dysfunction and CVD (cardiovascular disease) in Type 2 diabetes mellitus. While statin therapy reduces CVD in these patients, residual risk remains high. Fenofibrate corrects atherogenic...
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Clin Sci (Lond) (2009) 117 (5): 173–190.
Published: 03 August 2009
...Richard M. Cubbon; Matthew B. Kahn; Stephen B. Wheatcroft Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction...
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Clin Sci (Lond) (2009) 116 (10): 741–760.
Published: 15 April 2009
... ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. diabetic cardiomyopathy heart failure hyperglycaemia Type 2 diabetes The link between HF (heart...
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Clin Sci (Lond) (2009) 116 (7): 565–574.
Published: 02 March 2009
... in diabetes. C-peptide G-protein-coupled receptor proinsulin Type 1 diabetes Type 2 diabetes To exert hormone-like activity, C-peptide must have a receptor. Specific displaceable binding of C-peptide to pancreatic islet β-cells was initially described by Flatt et al. [ 6 ]. Ido and co...
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Clin Sci (Lond) (2009) 116 (2): 113–123.
Published: 15 December 2008
... understood. This short review highlights the effect of increasing fat mass on ectopic fat accumulation, the role of triacylglycerols (triglycerides) in Type 2 diabetes mellitus and cardiovascular disease pathogenesis, and selected current therapeutic strategies used to ameliorate these risk factors...
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Clin Sci (Lond) (2009) 116 (2): 99–111.
Published: 15 December 2008
...Wanzhu Jin; Mary-Elizabeth Patti T2DM (Type 2 diabetes mellitus) has reached epidemic proportions worldwide, exerting major health consequences at an individual and public health level alike. Unfortunately, the molecular pathophysiology of diabetes remains incompletely understood, impairing...
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Clin Sci (Lond) (2009) 116 (1): 81–86.
Published: 28 November 2008
..., we investigated whether the HSP70 gene polymorphisms affect susceptibility to DN (diabetic nephropathy) in patients with T2DM (Type 2 diabetes mellitus). The study group consisted of 452 patients with nephropathy. Two control subgroups involved 340 healthy individuals and 132 patients with T2DM...
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Clin Sci (Lond) (2009) 116 (1): 17–26.
Published: 28 November 2008
... homoeostasis, cell proliferation, inflammation, reproduction and renoprotection. A large body of research over the past decade has revealed that, in addition to their insulin-sensitizing effects, TZDs play an important role in delaying and preventing the progression of chronic kidney disease in Type 2 diabetes...
Articles
Clin Sci (Lond) (2008) 115 (11): 327–334.
Published: 03 November 2008
...-II ( UTS2 ) is associated with the onset of Type 2 diabetes and insulin resistance in the Japanese population. In the present study, we have demonstrated a relationship between plasma U-II levels and the progression of diabetic retinopathy and vascular complications in patients with Type 2 diabetes...