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Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage

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Clinical and translational research highlights
Simon T. Christensen, Kristian A. Haanes, Stine Spray, Anne-Sofie Grell, Karin Warfvinge, Lars Edvinsson, Sara E. Johansson
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1797–1811.
https://doi.org/10.1042/CS20190636
Published: 20 August 2019
... delayed brain injury may occur days after the initial ischemic insult and is associated with vasospasms leading to delayed cerebral ischemia. We have previously shown that the MEK1/2 inhibitor U0126 improves neurological assessment after SAH in rats. Aim: The purpose of the present study was to analyse...
View articletitled, Pre-clinical effects of highly potent MEK1/2 inhibitors on rat cerebral vasculature after organ culture and subarachnoid haemorrhage
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Includes: Supplementary data