... and contribution to fibrotic vascular remodelling in COPD. Schematic representation showing cigarette smoking and COPD activating TGG-β/SMAD and Wnt/ β-catenin pathways. Both pathways initiate and possibly interacts with each other to activate endothelial-to-mesenchymal transition (EndMT) in vasculature. During...

...Justyna Totoń-Żurańska; Tomasz P. Mikolajczyk; Blessy Saju; Tomasz J. Guzik Optimal vascular structure and function are essential for maintaining the physiological functions of the cardiovascular system. Vascular remodelling involves changes in vessel structure, including its size, shape, cellular...

... of MR in this process needs further studies. Thus, we tested the hypothesis that MR, through redox-sensitive mechanisms, plays a role in diabetes-associated vascular remodelling. Male, 12–14-weeks-old db/db mice, a model of type 2 diabetes and their non-diabetic counterpart controls (db/+) were treated...

... reported in atherosclerosis and hypertension. Different subsets of lymphocytes and their cytokines are involved in vascular remodelling in hypertension, chronic kidney disease and heart disease. Effector T-cells include Th1 (interferon-γ-producing) and Th2 (interleukin-4 producing) lymphocytes, as well...

... induces favourable effects similar to that induced by ACE (angiotensin-converting enzyme) inhibition in improving vascular remodelling through different mechanisms. Correspondence: Professor Carmine Savoia (email [email protected] ). 30 7 2012 22 2 2013 26 2 2013 26 2 2013...

...Lara del Campo; Bilge Guvenc Tuna; Mercedes Ferrer; Ed van Bavel; Erik N.T.P. Bakker Increasing evidence shows that sex hormones exert a protective effect on the vasculature, especially in the regulation of the active vasomotor responses. However, whether sex hormones affect vascular remodelling...

...), such as atherosclerosis or hypertension, in later life. Whether or not IUGR contributes to the development of atherosclerotic lesions, however, is unclear. We tested the hypothesis that IUGR aggravates experimentally induced vascular remodelling. IUGR was induced in rats by maternal protein restriction during pregnancy...

... is properly cited. cardiovascular disease exercise training intima-media thickness physical fitness vascular remodelling Coronary and cerebrovascular diseases are leading causes of morbidity and mortality [ 1 ]. Exercise is associated with decreased cardiovascular risk [ 2 , 3...

...-mail [email protected] ). 31 3 1999 21 6 1999 10 8 1999 The Biochemical Society and the Medical Research Society © 2000 2000 airway remodelling angiotensin II asthma rat renin vascular remodelling 1Clinical Science (2000) 98, 1 7 (Printed in Great Britain) Effects...