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Keywords: Wound healingClose
Clin Sci (Lond) (2019) 133 (4): 565–582.
Published: 18 February 2019
... protein (NLRP) 3 inflammasome in macrophages (MΦ) contributes to the sustained inflammatory response and impaired wound healing associated with diabetes. However, the main trigger of NLRP3 inflammasome in the wounds is not known. Neutrophils, as sentinels of the innate immune system and key stimulators of...
Clin Sci (Lond) (2018) 132 (15): 1629–1643.
Published: 14 August 2018
...Patricia E. Martin; Erin M. O’Shaughnessy; Catherine S. Wright; Annette Graham Impaired wound healing and ulceration caused by diabetes mellitus, is a significant healthcare burden, markedly impairs quality of life for patients, and is the major cause of amputation worldwide. Current experimental...
Clin Sci (Lond) (2014) 127 (3): 149–161.
Published: 03 April 2014
... factor (MIF) myocardial ischaemia myocardial infarction wound healing MIF (macrophage migration inhibitory factor) is a highly conserved molecule with pleiotropic actions, partly reflected by its present and previously assigned names as glycosylation-inhibiting factor, L -dopachrome isomerase...
Alessandra Bitto, Natasha Irrera, Letteria Minutoli, Margherita Calò, Patrizia Lo Cascio, Paolo Caccia, Gabriele Pizzino, Giovanni Pallio, Antonio Micali, Mario Vaccaro, Antonino Saitta, Francesco Squadrito, Domenica Altavilla
Clin Sci (Lond) (2013) 125 (12): 575–585.
Published: 02 August 2013
... VEGF (vascular endothelial growth factor), and impaired vasculogenesis during healing. Experimental evidence suggests that RLX (relaxin) can improve several parameters associated with wound healing. Therefore we investigated the effects of porcine-derived RLX in diabetes-related wound-healing defects...
Clin Sci (Lond) (2013) 124 (3): 123–137.
Published: 02 October 2012
... thrombosis and wound healing with a particular focus on: (i) the influence of plasma FXIIIa on the formation of stable fibrin clots able to withstand mechanical and enzymatic breakdown through fibrin–fibrin cross-linking and cross-linking of fibrinolysis inhibitors, in particular α 2 -antiplasmin; (ii) the...
Alessandra Bitto, Letteria Minutoli, Maria Rosaria Galeano, Domenica Altavilla, Francesca Polito, Tiziana Fiumara, Margherita Calò, Patrizia Lo Cascio, Lorena Zentilin, Mauro Giacca, Francesco Squadrito
Clin Sci (Lond) (2008) 114 (12): 707–718.
Published: 14 May 2008
...Alessandra Bitto; Letteria Minutoli; Maria Rosaria Galeano; Domenica Altavilla; Francesca Polito; Tiziana Fiumara; Margherita Calò; Patrizia Lo Cascio; Lorena Zentilin; Mauro Giacca; Francesco Squadrito Ang-1 (angiopoietin-1) improves the ineffective angiogenesis and impaired wound healing in...
Jorge BERLANGA, Danay CIBRIAN, Isabel GUILLÉN, Freya FREYRE, José S. ALBA, Pedro LOPEZ-SAURA, Nelson MERINO, Alfredo ALDAMA, Ana M. QUINTELA, Maria E. TRIANA, Jose F. MONTEQUIN, Hussam AJAMIEH, Dioslaida URQUIZA, Naila AHMED, Paul J. THORNALLEY
Clin Sci (Lond) (2005) 109 (1): 83–95.
Published: 23 June 2005
... protein glycation in diabetes has been linked to the development of diabetic vascular complications. Diabetes is also associated with impaired wound healing. In the present study, we investigated if prolonged exposure of rats to MG (50–75 mg/kg of body weight) induced impairment of wound healing and...
Clin Sci (Lond) (1996) 90 (5): 417–425.
Published: 01 May 1996
... burns dermatan sulphate proteoglycans wound healing Clinical Science (1996) Qo, 417425 (Printed in Great Britain) 417 Chemical characterization and quantification of proteoglycans in human post-burn hypertrophic and mature scars P. G. SCOTT*, C. M. DODD*, E. E. TREDGETt, A. GHAHARYt and F...
Clin Sci (Lond) (1995) 89 (4): 383–388.
Published: 01 October 1995
... delay in wound healing. 2. A group of rats was fed 58% of the voluntary food intake of a matched control group. After 7 days half the rats in each group underwent abdominal surgery. Forty-eight hours later all the rats were killed and muscle protein synthesis rate was measured by the flooding dose...