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Keywords: abdominal aortic aneurysm
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Articles
Clin Sci (Lond) (2025) CS20255689.
Published: 12 March 2025
...Mark Ensor; Sean Thatcher; Kristen McQuerry; Kory Heier; Heba Ali; Vicki English; Lisa Cassis; Yasir Alsiraj Cigarette smoking is a risk factor for abdominal aortic aneurysms (AAAs), with studies suggesting a higher smoking-related AAA risk in women than men. We examined nicotine’s effects...
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Clin Sci (Lond) (2023) 137 (19): 1533–1545.
Published: 03 October 2023
...Yi Zhao; Qi-Rui Shen; Yu-Xin Chen; Yu Shi; Wen-Bing Wu; Qiao Li; Dong-Jie Li; Fu-Ming Shen; Hui Fu Abdominal aortic aneurysm (AAA) is characterized by at least 1.5-fold enlargement of the infrarenal aorta, a ruptured AAA is life-threatening. Colchicine is a medicine used to treat gout and familial...
Includes: Supplementary data
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Clin Sci (Lond) (2023) 137 (15): 1167–1194.
Published: 10 August 2023
...Lídia Puertas-Umbert; Rafael Almendra-Pegueros; Francesc Jiménez-Altayó; Marc Sirvent; María Galán; José Martínez-González; Cristina Rodríguez Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease...
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Clin Sci (Lond) (2023) 137 (12): 979–993.
Published: 28 June 2023
... proliferation and migration. Clinical studies have indicated that circulating ANGPTL8 levels are increased in patients with thoracic aortic dissection (TAD). TAD shares several risk factors with abdominal aortic aneurysm (AAA). However, the role of ANGPTL8 in AAA pathogenesis has never been investigated. Here...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (17): 2085–2097.
Published: 01 September 2021
... the hypothesis that PP2A regulates abdominal aortic aneurysm (AAA) progression in a murine model. In an angiotensin II-induced AAA murine model, the PP2A inhibitor, LB-100, markedly accelerated AAA progression as demonstrated by increased abdominal aortic dilation and mortality. AAA progression was associated...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (10): 1295–1309.
Published: 28 May 2021
...Antigona Ulndreaj; Angela Li; Yonghong Chen; Rickvinder Besla; Shaun Pacheco; Marwan G. Althagafi; Myron I. Cybulsky; Thomas Lindsay; Clinton S. Robbins; John S. Byrne Objective: Aortic macrophage accumulation is characteristic of the pathogenesis of abdominal aortic aneurysm (AAA...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (22): 2959–2976.
Published: 16 November 2020
...Chongyang Zhang; Chia George Hsu; Amy Mohan; Hangchuan Shi; Dongmei Li; Chen Yan Abdominal aortic aneurysm (AAA), commonly occurring in the aged population, is a degenerative disease that dilate and weaken infrarenal aorta due to progressive degeneration of aortic wall integrity. Vinpocetine...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (12): 1555–1572.
Published: 25 June 2020
...Chetan P. Hans; Neekun Sharma; Rishabh Dev; Jones M. Blain; Jeff Tonniges; Gunjan Agarwal Abdominal aortic aneurysm (AAA) is a localized pathological dilation of the aorta exceeding the normal diameter (∼20 mm) by more than 50% of its original size (≥30 mm), accounting for approximately 150000...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (9): 1049–1061.
Published: 04 May 2020
...Corey S. Moran; Sai-Wang Seto; Erik Biros; Smriti M. Krishna; Susan K. Morton; Christoph Kleinschnitz; Con Panousis; Jonathan Golledge Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important...
Includes: Supplementary data
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Clin Sci (Lond) (2020) 134 (1): 33–37.
Published: 03 January 2020
...Keisuke Okuno; Stephanie Cicalese; Satoru Eguchi Chronic inflammation of the arterial wall has been implicated in the development of abdominal aortic aneurysm (AAA). However, the detailed molecular mechanism(s) by which inflammatory cells contributes to AAA pathogenesis remains largely unclear...
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Clin Sci (Lond) (2019) 133 (19): 2023–2028.
Published: 11 October 2019
...Masashi Miyao; Stephanie Cicalese; Hannah A. Cooper; Satoru Eguchi Endoplasmic reticulum (ER) and mitochondria are crucial organelles for cell homeostasis and alterations of these organelles have been implicated in cardiovascular disease. However, their roles in abdominal aortic aneurysm (AAA...
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Clin Sci (Lond) (2019) 133 (13): 1421–1438.
Published: 05 July 2019
...Miquel Navas-Madroñal; Cristina Rodriguez; Modar Kassan; Joan Fité; José R. Escudero; Laia Cañes; José Martínez-González; Mercedes Camacho; María Galán Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical...
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Clin Sci (Lond) (2017) 131 (7): 609–620.
Published: 17 March 2017
... on hypertensive cardiovascular remodelling in mice. However the role of myeloid lineage HIF-1α in the development of abdominal aortic aneurysm (AAA) has not been determined. Myeloid-specific HIF-1α knockout (HIF-1KO) mice were created using a Cre-lox recombination system in the background of apolipoprotein E...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (12): 1027–1038.
Published: 06 May 2016
...-Ventura Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. For that purpose, plasma...
Includes: Supplementary data
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Clin Sci (Lond) (2016) 130 (5): 301–315.
Published: 26 January 2016
...Theophilus I. Emeto; Joseph V. Moxon; Minnie Au; Jonathan Golledge Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress...
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Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... from abdominal aortic aneurysm (AAA), which is probably due to suppression of vascular endoplasmic reticulum (ER) stress. Since the signal was confirmed in humans, EGFR may provide a novel therapeutic target for aortic aneurysm. 1 These authors contributed equally. Correspondence : Dr...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 127 (7): 475–484.
Published: 17 June 2014
...Erik Biros; Corey S. Moran; Philip J. Walker; John Cardinal; Jonathan Golledge Current efforts to identify the genetic contribution to abdominal aortic aneurysm (AAA) have mainly focused on the assessment of germ-line variants such as single-nucleotide polymorphisms. The aim of the present study...
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Clin Sci (Lond) (2014) 127 (2): 123–134.
Published: 28 March 2014
.... In the present study, we examined whether aliskiren limits the progression of AAA (abdominal aortic aneurysm), VH (ventricular hypertrophy) and atherosclerosis in an AngII (angiotensin II)-infused mouse model. ApoE −/− (apolipoprotein-E-deficient) mice were infused subcutaneously with AngII (1000 ng/kg of body...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (11): 795–803.
Published: 21 February 2014
...Erik Biros; Corey S. Moran; Yutang Wang; Philip J. Walker; John Cardinal; Jonathan Golledge AAA (abdominal aortic aneurysm) is a potentially life-threatening late-onset degenerative condition. miRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown...
Includes: Supplementary data
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Clin Sci (Lond) (2014) 126 (11): 785–800.
Published: 13 February 2014
...Takehiko Takayanagi; Kevin J. Crawford; Tomonori Kobayashi; Takashi Obama; Toshiyuki Tsuji; Katherine J. Elliott; Tomoki Hashimoto; Victor Rizzo; Satoru Eguchi Although AngII (angiotensin II) and its receptor AT 1 R (AngII type 1 receptor) have been implicated in AAA (abdominal aortic aneurysm...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
...Hong Lu; Debra L. Rateri; Dennis Bruemmer; Lisa A. Cassis; Alan Daugherty Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs (thoracic aortic aneurysms) are two common forms of aneurysmal...
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