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Keywords: abdominal aortic aneurysm
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Articles

Colchicine protects against the development of experimental abdominal aortic aneurysm

Yi Zhao, Qi-Rui Shen, Yu-Xin Chen, Yu Shi, Wen-Bing Wu, Qiao Li, Dong-Jie Li, Fu-Ming Shen, Hui Fu
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1533–1545.
https://doi.org/10.1042/CS20230499
Published: 03 October 2023
...Yi Zhao; Qi-Rui Shen; Yu-Xin Chen; Yu Shi; Wen-Bing Wu; Qiao Li; Dong-Jie Li; Fu-Ming Shen; Hui Fu Abdominal aortic aneurysm (AAA) is characterized by at least 1.5-fold enlargement of the infrarenal aorta, a ruptured AAA is life-threatening. Colchicine is a medicine used to treat gout and familial...
View article titled, Colchicine protects against the development of experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Colchicine protects against the development of experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Includes: Supplementary data
Articles

Novel pharmacological approaches in abdominal aortic aneurysm

Lídia Puertas-Umbert, Rafael Almendra-Pegueros, Francesc Jiménez-Altayó, Marc Sirvent, María Galán, José Martínez-González, Cristina Rodríguez
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1167–1194.
https://doi.org/10.1042/CS20220795
Published: 10 August 2023
...Lídia Puertas-Umbert; Rafael Almendra-Pegueros; Francesc Jiménez-Altayó; Marc Sirvent; María Galán; José Martínez-González; Cristina Rodríguez Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease...
View article titled, Novel pharmacological approaches in <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Novel pharmacological approaches in <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Articles

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE −/− mice

Huahui Yu, Xiaolu Jiao, Yunyun Yang, Qianwen Lv, Zhiyong Du, Linyi Li, Chaowei Hu, Yunhui Du, Jing Zhang, Fan Li, Qiuju Sun, Yu Wang, Dong Chen, Xiaoping Zhang, Yanwen Qin
Journal: Clinical Science
Clin Sci (Lond) (2023) 137 (12): 979–993.
https://doi.org/10.1042/CS20230031
Published: 28 June 2023
... proliferation and migration. Clinical studies have indicated that circulating ANGPTL8 levels are increased in patients with thoracic aortic dissection (TAD). TAD shares several risk factors with abdominal aortic aneurysm (AAA). However, the role of ANGPTL8 in AAA pathogenesis has never been investigated. Here...
View article titled, ANGPTL8 deletion attenuates <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation in ApoE −&#x2F;− mice
Open the PDF for ANGPTL8 deletion attenuates <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation in ApoE −/− mice in another window
Includes: Supplementary data
Articles

Role of prostaglandin D 2 receptors in the pathogenesis of abdominal aortic aneurysm formation

Neal L. Weintraub, Andra L. Blomkalns, Mourad Ogbi, Tetsuo Horimatsu, Tyler W. Benson, Yuqing Huo, David J. Fulton, Gautam Agarwal, Richard Lee, Michael A. Winkler, Lufei Young, Ken Fujise, Avirup Guha, Tohru Fukai, Masuko Ushio-Fukai, Xiaochun Long, Brian H. Annex, Ha Won Kim
Journal: Clinical Science
Clin Sci (Lond) (2022) 136 (5): 309–321.
https://doi.org/10.1042/CS20220031
Published: 02 March 2022
...-ND) . abdominal aortic aneurysm angiotensin converting enzyme 2 calcium chloride fevipiprant laropiprant prostaglandin D2 Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease, characterized by immune cell infiltration and proteolytic degradation of the vascular wall...
View article titled, Role of prostaglandin D 2 receptors in the pathogenesis of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation
Open the PDF for Role of prostaglandin D 2 receptors in the pathogenesis of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation in another window
Includes: Supplementary data
Articles

Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm

Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong, Zhiyong Lin
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2085–2097.
https://doi.org/10.1042/CS20210315
Published: 01 September 2021
... the hypothesis that PP2A regulates abdominal aortic aneurysm (AAA) progression in a murine model. In an angiotensin II-induced AAA murine model, the PP2A inhibitor, LB-100, markedly accelerated AAA progression as demonstrated by increased abdominal aortic dilation and mortality. AAA progression was associated...
View article titled, Allosteric activation of PP2A inhibits experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Allosteric activation of PP2A inhibits experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Includes: Supplementary data
Articles

Adventitial recruitment of Lyve-1 − macrophages drives aortic aneurysm in an angiotensin-2-based murine model

Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Journal: Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1295–1309.
https://doi.org/10.1042/CS20200963
Published: 28 May 2021
...Antigona Ulndreaj; Angela Li; Yonghong Chen; Rickvinder Besla; Shaun Pacheco; Marwan G. Althagafi; Myron I. Cybulsky; Thomas Lindsay; Clinton S. Robbins; John S. Byrne Objective: Aortic macrophage accumulation is characteristic of the pathogenesis of abdominal aortic aneurysm (AAA...
View article titled, Adventitial recruitment of Lyve-1 − macrophages drives aortic aneurysm in an angiotensin-2-based murine model
Open the PDF for Adventitial recruitment of Lyve-1 − macrophages drives aortic aneurysm in an angiotensin-2-based murine model in another window
Includes: Supplementary data
Articles

Vinpocetine protects against the development of experimental abdominal aortic aneurysms

Chongyang Zhang, Chia George Hsu, Amy Mohan, Hangchuan Shi, Dongmei Li, Chen Yan
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (22): 2959–2976.
https://doi.org/10.1042/CS20201057
Published: 16 November 2020
...Chongyang Zhang; Chia George Hsu; Amy Mohan; Hangchuan Shi; Dongmei Li; Chen Yan Abdominal aortic aneurysm (AAA), commonly occurring in the aged population, is a degenerative disease that dilate and weaken infrarenal aorta due to progressive degeneration of aortic wall integrity. Vinpocetine...
View article titled, Vinpocetine protects against the development of experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysms</span>
Open the PDF for Vinpocetine protects against the development of experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysms</span> in another window
Includes: Supplementary data
Articles

Vitamin D deficiency promotes large rupture-prone abdominal aortic aneurysms and cholecalciferol supplementation limits progression of aneurysms in a mouse model

Vianne Nsengiyumva, Smriti M. Krishna, Corey S. Moran, Joseph V. Moxon, Susan K. Morton, Michael W. Clarke, Sai-Wang Seto, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (18): 2521–2534.
https://doi.org/10.1042/CS20200980
Published: 29 September 2020
...Vianne Nsengiyumva; Smriti M. Krishna; Corey S. Moran; Joseph V. Moxon; Susan K. Morton; Michael W. Clarke; Sai-Wang Seto; Jonathan Golledge Vitamin D deficiency has been associated with human abdominal aortic aneurysm (AAA); however, its role in AAA pathogenesis is unclear. The aim of the present...
View article titled, Vitamin D deficiency promotes large rupture-prone <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysms</span> and cholecalciferol supplementation limits progression of aneurysms in a mouse model
Open the PDF for Vitamin D deficiency promotes large rupture-prone <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysms</span> and cholecalciferol supplementation limits progression of aneurysms in a mouse model in another window
Includes: Supplementary data
Articles

DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways

Chetan P. Hans, Neekun Sharma, Rishabh Dev, Jones M. Blain, Jeff Tonniges, Gunjan Agarwal
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1555–1572.
https://doi.org/10.1042/CS20200456
Published: 25 June 2020
...Chetan P. Hans; Neekun Sharma; Rishabh Dev; Jones M. Blain; Jeff Tonniges; Gunjan Agarwal Abdominal aortic aneurysm (AAA) is a localized pathological dilation of the aorta exceeding the normal diameter (∼20 mm) by more than 50% of its original size (≥30 mm), accounting for approximately 150000...
View article titled, DAPT, a potent Notch inhibitor regresses actively growing <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> via divergent pathways
Open the PDF for DAPT, a potent Notch inhibitor regresses actively growing <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> via divergent pathways in another window
Includes: Supplementary data
Articles

Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice

Corey S. Moran, Sai-Wang Seto, Erik Biros, Smriti M. Krishna, Susan K. Morton, Christoph Kleinschnitz, Con Panousis, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (9): 1049–1061.
https://doi.org/10.1042/CS20191020
Published: 04 May 2020
...Corey S. Moran; Sai-Wang Seto; Erik Biros; Smriti M. Krishna; Susan K. Morton; Christoph Kleinschnitz; Con Panousis; Jonathan Golledge Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important...
View article titled, Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice
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Includes: Supplementary data
Articles

Depletion of CD11c + cell attenuates progression of abdominal aortic aneurysm

Keisuke Okuno, Stephanie Cicalese, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (1): 33–37.
https://doi.org/10.1042/CS20191083
Published: 03 January 2020
...Keisuke Okuno; Stephanie Cicalese; Satoru Eguchi Chronic inflammation of the arterial wall has been implicated in the development of abdominal aortic aneurysm (AAA). However, the detailed molecular mechanism(s) by which inflammatory cells contributes to AAA pathogenesis remains largely unclear...
View article titled, Depletion of CD11c + cell attenuates progression of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Depletion of CD11c + cell attenuates progression of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Articles

Depletion of CD11c + dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced abdominal aortic aneurysm formation and growth

Smriti M. Krishna, Corey S. Moran, Roby J. Jose, Sharon Lazzaroni, Pacific Huynh, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2203–2215.
https://doi.org/10.1042/CS20190924
Published: 12 November 2019
...Smriti M. Krishna; Corey S. Moran; Roby J. Jose; Sharon Lazzaroni; Pacific Huynh; Jonathan Golledge Objective: The role of chronic inflammation in abdominal aortic aneurysm (AAA) is controversial. CD11c + antigen-presenting cells (APCs) (dendritic cells (DCs)) have been reported in human AAA...
View article titled, Depletion of CD11c + dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation and growth
Open the PDF for Depletion of CD11c + dendritic cells in apolipoprotein E-deficient mice limits angiotensin II-induced <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation and growth in another window
Includes: Supplementary data
Articles

Endoplasmic reticulum stress and mitochondrial biogenesis are potential therapeutic targets for abdominal aortic aneurysm

Masashi Miyao, Stephanie Cicalese, Hannah A. Cooper, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (19): 2023–2028.
https://doi.org/10.1042/CS20190648
Published: 11 October 2019
...Masashi Miyao; Stephanie Cicalese; Hannah A. Cooper; Satoru Eguchi Endoplasmic reticulum (ER) and mitochondria are crucial organelles for cell homeostasis and alterations of these organelles have been implicated in cardiovascular disease. However, their roles in abdominal aortic aneurysm (AAA...
View article titled, Endoplasmic reticulum stress and mitochondrial biogenesis are potential therapeutic targets for <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Endoplasmic reticulum stress and mitochondrial biogenesis are potential therapeutic targets for <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Articles

Enhanced endoplasmic reticulum and mitochondrial stress in abdominal aortic aneurysm

Miquel Navas-Madroñal, Cristina Rodriguez, Modar Kassan, Joan Fité, José R. Escudero, Laia Cañes, José Martínez-González, Mercedes Camacho, María Galán
Journal: Clinical Science
Clin Sci (Lond) (2019) 133 (13): 1421–1438.
https://doi.org/10.1042/CS20190399
Published: 05 July 2019
...Miquel Navas-Madroñal; Cristina Rodriguez; Modar Kassan; Joan Fité; José R. Escudero; Laia Cañes; José Martínez-González; Mercedes Camacho; María Galán Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical...
View article titled, Enhanced endoplasmic reticulum and mitochondrial stress in <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Enhanced endoplasmic reticulum and mitochondrial stress in <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Includes: Supplementary data
Articles

Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development

Carlos-Ernesto Fernandez-García, Carlos Tarin, Raquel Roldan-Montero, Diego Martinez-Lopez, Monica Torres-Fonseca, Jes S. Lindhot, Melina Vega de Ceniga, Jesus Egido, Natalia Lopez-Andres, Luis-Miguel Blanco-Colio, Jose-Luis Martín-Ventura
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (22): 2707–2719.
https://doi.org/10.1042/CS20171142
Published: 06 November 2017
...Carlos-Ernesto Fernandez-García; Carlos Tarin; Raquel Roldan-Montero; Diego Martinez-Lopez; Monica Torres-Fonseca; Jes S. Lindhot; Melina Vega de Ceniga; Jesus Egido; Natalia Lopez-Andres; Luis-Miguel Blanco-Colio; Jose-Luis Martín-Ventura Abdominal aortic aneurysm (AAA) evolution is unpredictable...
View article titled, Increased galectin-3 levels are associated with <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> progression and inhibition of galectin-3 decreases elastase-induced AAA development
Open the PDF for Increased galectin-3 levels are associated with <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> progression and inhibition of galectin-3 decreases elastase-induced AAA development in another window
Includes: Supplementary data
Articles

AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice

Friedrich Krueger, Kai Kappert, Anna Foryst-Ludwig, Frederike Kramer, Markus Clemenz, Aleksandra Grzesiak, Manuela Sommerfeld, Jan Paul Frese, Andreas Greiner, Ulrich Kintscher, Thomas Unger, Elena Kaschina
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1989–2005.
https://doi.org/10.1042/CS20170131
Published: 13 July 2017
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 angiotensin high-fat diet vascular remodeling abdominal aortic aneurysm MMP In the Western World, vascular diseases and their consequences account for a majority of deaths. Arterial hypertension...
View article titled, AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice
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Articles

High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice

Smriti Murali Krishna, Sai Wang Seto, Roby Jose, Jiaze Li, Joseph Moxon, Paula Clancy, David J. Crossman, Paul Norman, Theophilus I. Emeto, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1261–1281.
https://doi.org/10.1042/CS20160970
Published: 07 June 2017
...Smriti Murali Krishna; Sai Wang Seto; Roby Jose; Jiaze Li; Joseph Moxon; Paula Clancy; David J. Crossman; Paul Norman; Theophilus I. Emeto; Jonathan Golledge Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic...
View article titled, High serum thrombospondin-1 concentration is associated with slower <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice
Open the PDF for High serum thrombospondin-1 concentration is associated with slower <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice in another window
Includes: Supplementary data
Articles

Deletion of hypoxia-inducible factor-1α in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm

Yusuke Takahara, Tomotake Tokunou, Hiroshi Kojima, Yoshitaka Hirooka, Toshihiro Ichiki
Journal: Clinical Science
Clin Sci (Lond) (2017) 131 (7): 609–620.
https://doi.org/10.1042/CS20160865
Published: 17 March 2017
... on hypertensive cardiovascular remodelling in mice. However the role of myeloid lineage HIF-1α in the development of abdominal aortic aneurysm (AAA) has not been determined. Myeloid-specific HIF-1α knockout (HIF-1KO) mice were created using a Cre-lox recombination system in the background of apolipoprotein E...
View article titled, Deletion of hypoxia-inducible factor-1α in myeloid lineage exaggerates angiotensin II-induced formation of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
Open the PDF for Deletion of hypoxia-inducible factor-1α in myeloid lineage exaggerates angiotensin II-induced formation of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in another window
Includes: Supplementary data
Articles

Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression

Elena Burillo, Carlos Tarin, Monica-Maria Torres-Fonseca, Carlos-Ernesto Fernandez-García, Roxana Martinez-Pinna, Diego Martinez-Lopez, Patricia Llamas-Granda, Emilio Camafeita, Juan Antonio Lopez, Melina Vega de Ceniga, Michael Aviram, Jesus Egido, Luis-Miguel Blanco-Colio, Jose-Luis Martín-Ventura
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (12): 1027–1038.
https://doi.org/10.1042/CS20160185
Published: 06 May 2016
...-Ventura Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. For that purpose, plasma...
View article titled, Paraoxonase-1 overexpression prevents experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> progression
Open the PDF for Paraoxonase-1 overexpression prevents experimental <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> progression in another window
Includes: Supplementary data
Articles

Oxidative stress and abdominal aortic aneurysm: potential treatment targets

Theophilus I. Emeto, Joseph V. Moxon, Minnie Au, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (5): 301–315.
https://doi.org/10.1042/CS20150547
Published: 26 January 2016
...Theophilus I. Emeto; Joseph V. Moxon; Minnie Au; Jonathan Golledge Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress...
View article titled, Oxidative stress and <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>: potential treatment targets
Open the PDF for Oxidative stress and <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>: potential treatment targets in another window
Articles

Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model

Takashi Obama, Toshiyuki Tsuji, Tomonori Kobayashi, Yamato Fukuda, Takehiko Takayanagi, Yoshinori Taro, Tatsuo Kawai, Steven J. Forrester, Katherine J. Elliott, Eric Choi, Alan Daugherty, Victor Rizzo, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2015) 128 (9): 559–565.
https://doi.org/10.1042/CS20140696
Published: 11 February 2015
... from abdominal aortic aneurysm (AAA), which is probably due to suppression of vascular endoplasmic reticulum (ER) stress. Since the signal was confirmed in humans, EGFR may provide a novel therapeutic target for aortic aneurysm. 1 These authors contributed equally. Correspondence : Dr...
View article titled, Epidermal growth factor receptor inhibitor protects against <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in a mouse model
Open the PDF for Epidermal growth factor receptor inhibitor protects against <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> in a mouse model in another window
Includes: Supplementary data
Articles

A deletion in chromosome 6q is associated with human abdominal aortic aneurysm

Erik Biros, Corey S. Moran, Philip J. Walker, John Cardinal, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (7): 475–484.
https://doi.org/10.1042/CS20130784
Published: 17 June 2014
...Erik Biros; Corey S. Moran; Philip J. Walker; John Cardinal; Jonathan Golledge Current efforts to identify the genetic contribution to abdominal aortic aneurysm (AAA) have mainly focused on the assessment of germ-line variants such as single-nucleotide polymorphisms. The aim of the present study...
View article titled, A deletion in chromosome 6q is associated with human <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>
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Articles

Aliskiren limits abdominal aortic aneurysm, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model

Sai-Wang Seto, Smriti M. Krishna, Corey S. Moran, David Liu, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2014) 127 (2): 123–134.
https://doi.org/10.1042/CS20130382
Published: 28 March 2014
.... In the present study, we examined whether aliskiren limits the progression of AAA (abdominal aortic aneurysm), VH (ventricular hypertrophy) and atherosclerosis in an AngII (angiotensin II)-infused mouse model. ApoE −/− (apolipoprotein-E-deficient) mice were infused subcutaneously with AngII (1000 ng/kg of body...
View article titled, Aliskiren limits <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model
Open the PDF for Aliskiren limits <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span>, ventricular hypertrophy and atherosclerosis in an apolipoprotein-E-deficient mouse model in another window
Includes: Supplementary data
Articles

microRNA profiling in patients with abdominal aortic aneurysms: the significance of miR-155

Erik Biros, Corey S. Moran, Yutang Wang, Philip J. Walker, John Cardinal, Jonathan Golledge
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (11): 795–803.
https://doi.org/10.1042/CS20130599
Published: 21 February 2014
...Erik Biros; Corey S. Moran; Yutang Wang; Philip J. Walker; John Cardinal; Jonathan Golledge AAA (abdominal aortic aneurysm) is a potentially life-threatening late-onset degenerative condition. miRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown...
View article titled, microRNA profiling in patients with <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysms</span>: the significance of miR-155
Open the PDF for microRNA profiling in patients with <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysms</span>: the significance of miR-155 in another window
Includes: Supplementary data
Articles

Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase

Takehiko Takayanagi, Kevin J. Crawford, Tomonori Kobayashi, Takashi Obama, Toshiyuki Tsuji, Katherine J. Elliott, Tomoki Hashimoto, Victor Rizzo, Satoru Eguchi
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (11): 785–800.
https://doi.org/10.1042/CS20130660
Published: 13 February 2014
...Takehiko Takayanagi; Kevin J. Crawford; Tomonori Kobayashi; Takashi Obama; Toshiyuki Tsuji; Katherine J. Elliott; Tomoki Hashimoto; Victor Rizzo; Satoru Eguchi Although AngII (angiotensin II) and its receptor AT 1 R (AngII type 1 receptor) have been implicated in AAA (abdominal aortic aneurysm...
View article titled, Caveolin 1 is critical for <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation induced by angiotensin II and inhibition of lysyl oxidase
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Includes: Supplementary data
Articles

Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption

Aya Watanabe, Toshihiro Ichiki, Chikahiro Sankoda, Yusuke Takahara, Jiro Ikeda, Eriko Inoue, Tomotake Tokunou, Shiro Kitamoto, Kenji Sunagawa
Journal: Clinical Science
Clin Sci (Lond) (2014) 126 (9): 671–678.
https://doi.org/10.1042/CS20130435
Published: 22 January 2014
... (abdominal aortic aneurysm). AAA was induced in C57BL/6 mice by periaortic application of CaCl 2 (AAA group). NaCl (0.9%)-treated mice were used as a sham control (SHAM group). Mice were treated with 0.05% CoCl 2 in the drinking water (AAA/CoCl 2 group). At 1 and 6 weeks after the operation, aortic tissue...
View article titled, Suppression of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption
Open the PDF for Suppression of <span class="search-highlight">abdominal</span> <span class="search-highlight">aortic</span> <span class="search-highlight">aneurysm</span> formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption in another window
Articles

Involvement of the renin–angiotensin system in abdominal and thoracic aortic aneurysms

Hong Lu, Debra L. Rateri, Dennis Bruemmer, Lisa A. Cassis, Alan Daugherty
Journal: Clinical Science
Clin Sci (Lond) (2012) 123 (9): 531–543.
https://doi.org/10.1042/CS20120097
Published: 13 July 2012
...Hong Lu; Debra L. Rateri; Dennis Bruemmer; Lisa A. Cassis; Alan Daugherty Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs (thoracic aortic aneurysms) are two common forms of aneurysmal...
View article titled, Involvement of the renin–angiotensin system in abdominal and thoracic aortic aneurysms
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Articles

Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm

Jan H. N. Lindeman, Hazem Abdul-Hussien, Alexander F. M. Schaapherder, J. Hajo VAN Bockel, Jan H. VON DER Thüsen, Dave L. Roelen, Robert Kleemann
Journal: Clinical Science
Clin Sci (Lond) (2008) 114 (11): 687–697.
https://doi.org/10.1042/CS20070352
Published: 01 May 2008
...Jan H. N. Lindeman; Hazem Abdul-Hussien; Alexander F. M. Schaapherder; J. Hajo VAN Bockel; Jan H. VON DER Thüsen; Dave L. Roelen; Robert Kleemann Inflammation plays a key role in the pathogenesis of an AAA (abdominal aortic aneurysm); however, the nature of the inflammatory factors and cellular...
View article titled, Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
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