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Keywords: abdominal aortic aneurysm
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Articles
Clin Sci (Lond) (2021) 135 (17): 2085–2097.
Published: 01 September 2021
... the hypothesis that PP2A regulates abdominal aortic aneurysm (AAA) progression in a murine model. In an angiotensin II-induced AAA murine model, the PP2A inhibitor, LB-100, markedly accelerated AAA progression as demonstrated by increased abdominal aortic dilation and mortality. AAA progression was associated...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (10): 1295–1309.
Published: 28 May 2021
...Antigona Ulndreaj; Angela Li; Yonghong Chen; Rickvinder Besla; Shaun Pacheco; Marwan G. Althagafi; Myron I. Cybulsky; Thomas Lindsay; Clinton S. Robbins; John S. Byrne Objective: Aortic macrophage accumulation is characteristic of the pathogenesis of abdominal aortic aneurysm (AAA...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (22): 2959–2976.
Published: 16 November 2020
...Chongyang Zhang; Chia George Hsu; Amy Mohan; Hangchuan Shi; Dongmei Li; Chen Yan Abdominal aortic aneurysm (AAA), commonly occurring in the aged population, is a degenerative disease that dilate and weaken infrarenal aorta due to progressive degeneration of aortic wall integrity. Vinpocetine...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (18): 2521–2534.
Published: 29 September 2020
...Vianne Nsengiyumva; Smriti M. Krishna; Corey S. Moran; Joseph V. Moxon; Susan K. Morton; Michael W. Clarke; Sai-Wang Seto; Jonathan Golledge Vitamin D deficiency has been associated with human abdominal aortic aneurysm (AAA); however, its role in AAA pathogenesis is unclear. The aim of the present...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (12): 1555–1572.
Published: 25 June 2020
...Chetan P. Hans; Neekun Sharma; Rishabh Dev; Jones M. Blain; Jeff Tonniges; Gunjan Agarwal Abdominal aortic aneurysm (AAA) is a localized pathological dilation of the aorta exceeding the normal diameter (∼20 mm) by more than 50% of its original size (≥30 mm), accounting for approximately 150000...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (9): 1049–1061.
Published: 04 May 2020
...Corey S. Moran; Sai-Wang Seto; Erik Biros; Smriti M. Krishna; Susan K. Morton; Christoph Kleinschnitz; Con Panousis; Jonathan Golledge Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2020) 134 (1): 33–37.
Published: 03 January 2020
...Keisuke Okuno; Stephanie Cicalese; Satoru Eguchi Chronic inflammation of the arterial wall has been implicated in the development of abdominal aortic aneurysm (AAA). However, the detailed molecular mechanism(s) by which inflammatory cells contributes to AAA pathogenesis remains largely unclear...
Articles
Clin Sci (Lond) (2019) 133 (21): 2203–2215.
Published: 12 November 2019
...Smriti M. Krishna; Corey S. Moran; Roby J. Jose; Sharon Lazzaroni; Pacific Huynh; Jonathan Golledge Objective: The role of chronic inflammation in abdominal aortic aneurysm (AAA) is controversial. CD11c + antigen-presenting cells (APCs) (dendritic cells (DCs)) have been reported in human AAA...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (19): 2023–2028.
Published: 11 October 2019
...Masashi Miyao; Stephanie Cicalese; Hannah A. Cooper; Satoru Eguchi Endoplasmic reticulum (ER) and mitochondria are crucial organelles for cell homeostasis and alterations of these organelles have been implicated in cardiovascular disease. However, their roles in abdominal aortic aneurysm (AAA...
Articles
Clin Sci (Lond) (2019) 133 (13): 1421–1438.
Published: 05 July 2019
...Miquel Navas-Madroñal; Cristina Rodriguez; Modar Kassan; Joan Fité; José R. Escudero; Laia Cañes; José Martínez-González; Mercedes Camacho; María Galán Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a complex aetiology that remains to be fully elucidated. Clinical...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (22): 2707–2719.
Published: 06 November 2017
...Carlos-Ernesto Fernandez-García; Carlos Tarin; Raquel Roldan-Montero; Diego Martinez-Lopez; Monica Torres-Fonseca; Jes S. Lindhot; Melina Vega de Ceniga; Jesus Egido; Natalia Lopez-Andres; Luis-Miguel Blanco-Colio; Jose-Luis Martín-Ventura Abdominal aortic aneurysm (AAA) evolution is unpredictable...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 1989–2005.
Published: 13 July 2017
... high-fat diet vascular remodeling abdominal aortic aneurysm MMP In the Western World, vascular diseases and their consequences account for a majority of deaths. Arterial hypertension, obesity, and ageing facilitates development of outward remodeling of large vessels, which is characterized...
Articles
Clin Sci (Lond) (2017) 131 (12): 1261–1281.
Published: 07 June 2017
...Smriti Murali Krishna; Sai Wang Seto; Roby Jose; Jiaze Li; Joseph Moxon; Paula Clancy; David J. Crossman; Paul Norman; Theophilus I. Emeto; Jonathan Golledge Abdominal aortic aneurysm (AAA) is a common age-related vascular disease characterized by progressive weakening and dilatation of the aortic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (7): 609–620.
Published: 17 March 2017
... on hypertensive cardiovascular remodelling in mice. However the role of myeloid lineage HIF-1α in the development of abdominal aortic aneurysm (AAA) has not been determined. Myeloid-specific HIF-1α knockout (HIF-1KO) mice were created using a Cre-lox recombination system in the background of apolipoprotein E...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (12): 1027–1038.
Published: 06 May 2016
...-Ventura Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. For that purpose, plasma...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (5): 301–315.
Published: 26 January 2016
...Theophilus I. Emeto; Joseph V. Moxon; Minnie Au; Jonathan Golledge Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress...
Articles
Clin Sci (Lond) (2015) 128 (9): 559–565.
Published: 11 February 2015
... from abdominal aortic aneurysm (AAA), which is probably due to suppression of vascular endoplasmic reticulum (ER) stress. Since the signal was confirmed in humans, EGFR may provide a novel therapeutic target for aortic aneurysm. 1 These authors contributed equally. Correspondence : Dr...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (7): 475–484.
Published: 17 June 2014
...Erik Biros; Corey S. Moran; Philip J. Walker; John Cardinal; Jonathan Golledge Current efforts to identify the genetic contribution to abdominal aortic aneurysm (AAA) have mainly focused on the assessment of germ-line variants such as single-nucleotide polymorphisms. The aim of the present study...
Articles
Clin Sci (Lond) (2014) 127 (2): 123–134.
Published: 28 March 2014
.... In the present study, we examined whether aliskiren limits the progression of AAA (abdominal aortic aneurysm), VH (ventricular hypertrophy) and atherosclerosis in an AngII (angiotensin II)-infused mouse model. ApoE −/− (apolipoprotein-E-deficient) mice were infused subcutaneously with AngII (1000 ng/kg of body...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (11): 795–803.
Published: 21 February 2014
...Erik Biros; Corey S. Moran; Yutang Wang; Philip J. Walker; John Cardinal; Jonathan Golledge AAA (abdominal aortic aneurysm) is a potentially life-threatening late-onset degenerative condition. miRNAs (microRNAs), the small non-coding RNA molecules that regulate gene expression, have been shown...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (11): 785–800.
Published: 13 February 2014
...Takehiko Takayanagi; Kevin J. Crawford; Tomonori Kobayashi; Takashi Obama; Toshiyuki Tsuji; Katherine J. Elliott; Tomoki Hashimoto; Victor Rizzo; Satoru Eguchi Although AngII (angiotensin II) and its receptor AT 1 R (AngII type 1 receptor) have been implicated in AAA (abdominal aortic aneurysm...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (9): 671–678.
Published: 22 January 2014
... (abdominal aortic aneurysm). AAA was induced in C57BL/6 mice by periaortic application of CaCl 2 (AAA group). NaCl (0.9%)-treated mice were used as a sham control (SHAM group). Mice were treated with 0.05% CoCl 2 in the drinking water (AAA/CoCl 2 group). At 1 and 6 weeks after the operation, aortic tissue...
Articles
Clin Sci (Lond) (2012) 123 (9): 531–543.
Published: 13 July 2012
...Hong Lu; Debra L. Rateri; Dennis Bruemmer; Lisa A. Cassis; Alan Daugherty Aortic aneurysms are relatively common maladies that may lead to the devastating consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs (thoracic aortic aneurysms) are two common forms of aneurysmal...
Articles
Clin Sci (Lond) (2008) 114 (11): 687–697.
Published: 01 May 2008
...Jan H. N. Lindeman; Hazem Abdul-Hussien; Alexander F. M. Schaapherder; J. Hajo VAN Bockel; Jan H. VON DER Thüsen; Dave L. Roelen; Robert Kleemann Inflammation plays a key role in the pathogenesis of an AAA (abdominal aortic aneurysm); however, the nature of the inflammatory factors and cellular...