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Clin Sci (Lond) (1997) 93 (6): 585–591.
Published: 01 December 1997
... is rapidly cleared from the plasma to an unobservable pool at a rate similar to that of chylomicron triacylglycerol. 19 5 1997 24 7 1997 © 1997 The Biochemical Society and the Medical Research Society 1997 absorption all trans -β-carotene β-carotene 9- cis -β-carotene computer...
Clin Sci (Lond) (1995) 88 (2): 219–224.
Published: 01 February 1995
... in the jejuna of rats fed a diet high in polyunsaturated fatty acids. 5. Submaximal electrogenic galactose absorption was increased in the rats fed a diet high in polyunsaturated fatty acids. 6. Changing the composition of dietary lipid resulted in a change in the fatty composition of the apical enterocyte...
Clin Sci (Lond) (1994) 87 (1): 91–95.
Published: 01 July 1994
...Jon F. R. Barrett; Paul G Whittaker; John D. Fenwick; John G. Williams; Tom Lind 1. Stable isotope methods are being used to investigate the absorption of dietary iron. In order to be certain that this new methodology is accurate, we have compared results obtained using stable isotopes...
Clin Sci (Lond) (1994) 86 (5): 511–516.
Published: 01 May 1994
... in intestinal urate transport in rats with chronic renal failure compared with normal rats. Net absorption of urate was observed in the distal colon of control rats, whereas a significant secretory flux was observed in rats with chronic renal failure (from 0.88 ± 0.16 to −1.62 ± 0.81 nmol h −1 cm −2 , n = 12...
Clin Sci (Lond) (1994) 86 (3): 353–357.
Published: 01 March 1994
... absorptive flux of oxalate across the distal colon was significantly reduced in the presence of trichlormethiazide at 10 −4 mol/l. In contrast, this diuretic had no effect on oxalate transport in the other intestinal segments examined. Several of the thiazide diuretics tested had some inhibitory effect...
Clin Sci (Lond) (1992) 83 (5): 627–631.
Published: 01 November 1992
.... Absorption from the distal colon was impeded by the presence of faecal material in three of the eight subjects. 5. We conclude that human calcitonin crosses the gastrointestinal epithelium of man. This may demonstrate the feasibility of an oral form for clinical use. 18 6 1992 14 7 1992 ©...
Clin Sci (Lond) (1992) 82 (5): 589–594.
Published: 01 May 1992
...J. Hastewell; S. Lynch; I. Williamson; R. Fox; M. Mackay 1. We studied the absorption of human calcitonin across the colon of juvenile female rats in vivo. Both pharmacokinetic and pharmacodynamic parameters were monitored to measure absorption. 2. Intracolonically administered human calcitonin...
Clin Sci (Lond) (1988) 75 (5): 499–502.
Published: 01 November 1988
... glutamic acid reaches the extracellular pool. The majority of the administered nitrogen label appears in the arterial alanine and glutamine components. © 1970 The Biochemical Society and the Medical Research Society 1970 absorption glutamic acid metabolism nitrogen small intestine Clinical...
Clin Sci (Lond) (1988) 74 (3): 301–306.
Published: 01 March 1988
...R. A. Goodlad; J. A. Plumb; N. A. Wright 1. Intestinal epithelial cell production and intestinal absorption were measured in fed, starved and refed rats. 2. Four days' starvation significantly decreased the crypt cell production rate (CCPR), absorption, small intestinal length and crypt cell...
Clin Sci (Lond) (1987) 73 (2): 189–196.
Published: 01 August 1987
...I. Hamilton; J. Rothwell; D. Archer; A. T. R. Axon 1. Absorption of carbohydrate probe molecules from ligated loops of rat small intestine was studied. Absorption was determined by measuring recovery of molecules in the urine, corrected for incomplete recovery after intravenous injection...
Clin Sci (Lond) (1987) 73 (1): 53–59.
Published: 01 July 1987
...Jane A. Plumb; David Burston; Terry G. Baker; Michael L. G. Gardner 1. The structural integrities of various preparations of rat small intestine for the study of absorption in vitro have been compared after incubation or perfusion. 2. Perfused intestines removed from anaesthetized rats, and thus...
Clin Sci (Lond) (1987) 72 (6): 705–716.
Published: 01 June 1987
... was due to the lower serosal drug concentrations in the mesenteric circulation of the perfused intestine. 7. At a concentration of 5 mmol/l 5-fluorouracil inhibited water transport in the isolated loops and transmural D-galactose transport in the vascular perfusions. absorption 5-fluorouracil...
Clin Sci (Lond) (1987) 72 (4): 409–414.
Published: 01 April 1987
...B. J. M. Jones; B. E. Higgins; D. B. A. Silk 1. The jejunal absorption of glucose from (1–4)-linked glucose oligomers including maltotriose has been compared with that from free glucose and sucrose in normal subjects. 2. A steady-state perfusion technique in vivo was used to study proximal jejunal...
Clin Sci (Lond) (1987) 72 (3): 297–304.
Published: 01 March 1987
... if a valid measure of intestinal function could also be included. One such method is the water absorption capacity in vitro . 3. The intraperitoneal injection of vincristine sulphate (1 mg/kg) had no significant effect on the water absorption capacity of the small intestine, as measured by the segmented flow...
Clin Sci (Lond) (1984) 67 (1): 105–110.
Published: 01 July 1984
... subjects, compared with the control period results there were no changes in sodium, water and glucose absorption during the intravenous administration of hydrocortisone. In contrast, intraluminal hydrocortisone (100 mg/l) increased sodium, water and glucose absorption by 169%, 223% and 81% respectively ( P...
Clin Sci (Lond) (1983) 64 (4): 433–439.
Published: 01 April 1983
... of fasted animals. 2. Furthermore, there is a significant increase in the peptide content of the mesenteric venous blood during intraduodenal infusion of a partial digest of casein. 3. The data are consistent with the view that some 10% of the amino nitrogen entering the mesenteric blood during absorption...
Clin Sci (Lond) (1982) 63 (3): 311–316.
Published: 01 September 1982
...J. S. Sandhu; D. R. Fraser 1. The intestinal absorption of a mixture of [ 3 H]cellobiotol and [ 14 C]mannitol was determined by measuring the 3 H/ 14 C ratio in urine after oral administration of the labelled sugars to rats. This index of intestinal permeability was used to identify cellular...
Clin Sci (Lond) (1982) 63 (1): 81–85.
Published: 01 July 1982
... of propranolol were similar in both groups. 2. With the use of a perfusion technique, propranolol absorption in the proximal jejunum was found to be decreased by 71% in five untreated coeliac patients, compared with the absorption in four normal subjects. 3. These results indicate that propranolol absorption...
Clin Sci (Lond) (1981) 61 (4): 477–481.
Published: 01 October 1981
...D. H. Marshall; B. E. C. Nordin 1. Four different methods of calculating calcium absorption by radioactive calcium procedures have been compared with each other and with net calcium absorption in calcium-balance studies in 100 consecutive studies on 71 patients. 2. All four isotope procedures...
Clin Sci (Lond) (1981) 60 (1): 115–118.
Published: 01 January 1981
...I. Cobden; Jill Rothwell; A. T. R. Axon 1. Experiments were performed to study the absorption of two simultaneously administered polar probes of different molecular size from closed intestinal loops in rats subjected to various mucosal structural lesions. 2. Absorption of mannitol (molecular radius...
Clin Sci (Lond) (1979) 56 (5): 407–412.
Published: 01 May 1979
...J. Walton; T. K. Gray 1. Intestinal phosphate absorption in human subjects was studied by the technique of triple lumen intestinal perfusion in vivo. 2. Ileal phosphate absorption increased as the intraluminal phosphate concentration was increased. 3. Ileal rates of phosphate absorption were lower...
Clin Sci (Lond) (1979) 56 (3): 243–249.
Published: 01 March 1979
...M. L. G. Gardner; R. C. Heading 1. Water absorption and cytoplasmic dipeptidase activities were determined in isolated rat small intestine after animals had fed on various ‘elemental’ diets or a standard rat diet and after a single injection of 5-fluorouracil. 2. Vivonex diets were associated...
Clin Sci Mol Med (1978) 54 (4): 411–418.
Published: 01 April 1978
...M. L. G. Gardner; R. R. Samson; R. C. Heading 1. Glucose absorption, water absorption and dipeptide hydrolase activities have been determined in isolated rat small intestine at 1, 3, 5 and 21 days after a single intraperitoneal injection of 5-fluorouracil. 2. Absorption rates and enzyme activities...
Clin Sci Mol Med (1977) 53 (3): 241–248.
Published: 01 September 1977
...P. D. Fairclough; D. B. A. Silk; J. P. W. Webb; M. L. Clark; A. M. Dawson 1. The validity of evidence for intact peptide absorption, derived from analysis of the relation of water and total solute absorption, has been tested. 2. Solute and water absorption from saline solutions of the disaccharide...
Clin Sci Mol Med (1977) 53 (1): 27–33.
Published: 01 July 1977
...P. D. Fairclough; D. B. A. Silk; M. L. Clark; D. M. Matthews; T. C. Marrs; D. Burston; K. M. Clegg 1. A jejunal perfusion technique has been used in normal volunteer subjects to study jejunal absorption of amino acid residues from a partial enzymic hydrolysate of casein in which about 50...
Clin Sci Mol Med (1977) 52 (6): 607–614.
Published: 01 June 1977
...R. C. Heading; H. P. Schedl; L. D. Stegink; D. L. Miller 1. Absorption of [ 3 H]glycine and [ 14 C]-glycyl-l-proline at concentrations between 0·5 and 4 mmol/l was studied by perfusion in vivo of rat jejunal and ileal segments. Absorption was defined as net removal of radioisotope from...
Clin Sci Mol Med (1976) 51 (5): 427–433.
Published: 01 November 1976
... that in lactation there is mucosal hyperplasia with increases in villus height and crypt depth, and in small-bowel wet and defatted dry-tissue weights per unit length of intestine. 3. There are corresponding changes in absorptive function with increased glucose and water absorption per unit length of intestine. 4...
Clin Sci Mol Med (1976) 51 (4): 363–368.
Published: 01 October 1976
...J. F. MacKenzie; R. I. Russell 1. Pteroylmonoglutamic acid (PteGlu) absorption has been measured by using the technique of small-intestinal perfusion with tritiated PteGlu in normal subjects and in patients with coeliac disease. 2. At similar intrajejunal pH, patients with untreated coeliac disease...
Clin Sci Mol Med (1976) 51 (2): 127–132.
Published: 01 August 1976
.... The absorption of d-glucose, galactose and 3- O -methyl-d-glucose was at least partly dependent on the presence of sodium ions in the luminal fluid. 5. The transport of d-glucose was inhibited by galactose and 3- O -methyl-d-glucose, suggesting at least one common carrier system. Clinical Science and Molecular...
Clin Sci Mol Med (1976) 50 (6): 499–509.
Published: 01 June 1976
...R. M. Batt; T. J. Peters 1. The absorption in vivo of d-galactose by the rat small intestine has been examined in proximal jejunum and distal ileum by use of a recirculation—perfusion technique. 2. Multiple sequential perfusions over 4 h produced no subsequent functional or morphological damage...
Clin Sci Mol Med (1976) 50 (6): 511–523.
Published: 01 June 1976
...R. M. Batt; T. J. Peters 1. The effects in rats of an oral pharmacological dose of prednisolone on mucosal function, enzymology, lysosomal membrane fragility, morphology and cell kinetics have been examined in proximal jejunum and distal ileum. 2. The maximum absorptive capacity for galactose...
Clin Sci Mol Med (1975) 49 (3): 237–245.
Published: 01 September 1975
...-bladder than hepatic bile. Between pH 5 and pH 8, this component had a greater binding affinity for copper than the other alimentary secretions or EDTA at a concentration of 10 mmol/l. 5. Absorption of 64 Cu from 64 Cu-labelled saliva, gastric juice or l-histidine solution (100 mmol/l) administered...
Clin Sci Mol Med (1975) 48 (4): 279–287.
Published: 01 April 1975
... and unidirectional transport of ammonia from lumen to plasma, but net absorption from high luminal concentrations persisted at low pH. 3. Neither addition of urea to the perfusate nor intravenous infusion of urea produced a consistent increase in the colonic excretion of ammonia when ammonia-free solutions were...
Clin Sci Mol Med (1973) 45 (5): 625–631.
Published: 01 November 1973
...D. G. Weir; J. P. Brown; D. S. Freedman; J. M. Scott 1. The two diastereoisomers of 5-methyltetrahydropteroylglutamate, the form of folate that predominates in food and bile, were prepared chemically. 2. Their intestinal absorption was compared by means of the urinary-excretion method of 3 H...
Clin Sci Mol Med (1973) 44 (1): 9–15.
Published: 01 January 1973
... weight exceeding 50 000. The remaining biliary 64 Cu was in a low-molecular-weight component. 3. Above pH 4, 64 Cu could not readily be removed from the macromolecular complex either by excess carrier copper ions, by d-penicillamine or by EDTA. 4. Absorption of 64 Cu from 64 Cu-labelled bile injected...
Clin Sci (1972) 43 (3): 443–453.
Published: 01 September 1972
...G. C. Cook 1. Using a double-lumen tube perfusion system the rates of glycine, glycylglycine, and glycylglycine and glucose absorption from a 30-cm jejunal segment have been studied in vivo in a group of relatively normal Zambian African subjects. 2. To determine the kinetic curve for glycine...
Clin Sci (1972) 43 (1): 101–114.
Published: 01 July 1972
... reaction that continues to generate unionized ammonia. 18 2 1972 © 1972 The Biochemical Society and the Medical Research Society 1972 faeces colon intestine pH ammonia bicarbonate absorption Clinical Science (1972) 43, 101-114. THE INTERRELATIONS O F FAECAL AMMONIA, pH...
Clin Sci (1972) 42 (5): 525–534.
Published: 01 May 1972
...G. C. Cook 1. To investigate the effect of different intraluminal concentrations on the mutual inhibitive effect of glycine and glucose on their jejunal absorption rates, eighteen convalescent Zambian African patients who had no clinical evidence of intestinal disease or of malnutrition were given...