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1-34 of 34
Keywords: acetylcholine
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Articles
Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity
Available to PurchaseShino Oikawa, Yuko Kai, Masayuki Tsuda, Hisayuki Ohata, Asuka Mano, Naoko Mizoguchi, Shuei Sugama, Takahiro Nemoto, Kenji Suzuki, Atsushi Kurabayashi, Kazuyo Muramoto, Makoto Kaneda, Yoshihiko Kakinuma
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (21): 1913–1928.
Published: 22 September 2016
...-overexpressing transgenic mice ( ChAT tgm), i.e. an in vivo model of the cardiac non-neuronal acetylcholine (NNA) system or non-neuronal cardiac cholinergic system (NNCCS). By using this murine model, we determined that this system was responsible for characteristics of resistance to ischaemia, or hypoxia, via...
Articles
Maheshwar Pauriah, Faisel Khan, Tiong K. Lim, Douglas H. Elder, Valerie Godfrey, Gwen Kennedy, Jill J. F. Belch, Nuala A. Booth, Allan D. Struthers, Chim C. Lang
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (5): 307–312.
Published: 16 May 2012
...). Endothelium-dependent vasodilatation was evaluated by the invasive ACH (acetylcholine)-induced forearm vasodilatation technique. A panel of biomarkers of biological pathways was measured: BNP, haemostatic factors PAI-1 (plasminogen-activator inhibitor 1) and tPA (tissue plasminogen activator), inflammatory...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (10): 449–458.
Published: 25 July 2011
... phosphorylation and contractile responses were also studied. Simvastatin (1 μM, 2 h) significantly reduced constriction to U46619 and phenylephrine and enhanced dilations to ACh (acetylcholine) in depolarized, but not in U46619-pre-constricted arteries. These effects were completely and partially prevented by L...
Articles
Long-term portal hypertension increases the vasodilator response to acetylcholine in rat aorta: role of prostaglandin I 2
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Journal:
Clinical Science
Clin Sci (Lond) (2009) 117 (10): 365–374.
Published: 07 September 2009
...Javier Blanco-Rivero; Ma Angeles Aller; Jaime Arias; Mercedes Ferrer; Gloria Balfagón In the present study, we have analysed both the effect of long-term portal hypertension on the vasomotor response to acetylcholine in rat aorta and the mechanism involved in this response. For this purpose, sham...
Articles
Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta
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Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (2): 145–151.
Published: 13 July 2006
... and time course of inhibition, and (v) the effect on nitric oxide production. Aortic rings were incubated (1 h) with NEFA–albumin complexes derived from lauric (C 12:0 ), myristic (C 14:0 ), palmitic (C 16:0 ), stearic (C 18:0 ) and linolenic (C 18:3 ) acids. EDR induced by acetylcholine (0.1–10 μmol/l...
Articles
Endothelial dysfunction in growth hormone transgenic mice
Available to PurchaseIrene J. Andersson, Maria E. Johansson, Anna Wickman, Mohammad Bohlooly-Y, Natalia Klintland, Kenneth Caidahl, Maria Gustafsson, Jan Borén, Li-ming Gan, Göran Bergström
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 217–225.
Published: 17 January 2006
.... We studied the ACh (acetylcholine)-induced relaxation response in aortic and carotid rings of young (9–11 weeks) and aged (22–24 weeks) female bGH transgenic mice and littermate control mice, without and with the addition of a free radical scavenger {MnTBAP [Mn(III)tetrakis(4-benzoic acid)porphyrin...
Articles
Contribution of prostanoids to endothelium-dependent vasodilatation in the digital circulation of women with primary Raynaud's disease
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Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (1): 45–54.
Published: 23 June 2005
...Melanie J. EASTER; Janice M. MARSHALL In 15 women with PR (primary Raynaud's) disease and in 15 matched control women, ACh (acetylcholine) was delivered by iontophoresis to the dorsum of the finger (seven 20 s pulses of 0.1 mA, followed by one 20 s pulse of 0.2 mA, applied at 60 s intervals...
Articles
Vasoconstrictor products of cyclo-oxygenase activity limit acetylcholine-induced cutaneous vasodilatation in young men
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Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (3): 323–330.
Published: 24 August 2004
...Ross G. HENDRY; Janice M. MARSHALL In healthy young men (age, 20–22 years), we tested the role of prostanoids produced by the COX (cyclo-oxygenase) pathway in cutaneous vasodilatation evoked in the finger by ACh (acetylcholine). To this end, changes in cutaneous RCF (red cell flux), recorded...
Articles
Coronary vasomotor response is related to the angiographic extent of coronary sclerosis in patients with stable angina pectoris
Available to PurchaseFolkert W. ASSELBERGS, Stefan H.J. MONNINK, Nic J.G.M. VEEGER, Ad J. VAN BOVEN, Paul L. VAN HAELST, Gillian A.J. JESSURUN, Wiek H. VAN GILST, René A. TIO
Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (2): 115–120.
Published: 01 February 2004
... to the potential risk for an ischaemic coronary event. In the present study, we have investigated the relationship between coronary vasomotor function and the extent of CAD. The response to acetylcholine and nitrate infusion was assessed by quantitative coronary angiography. The extent of CAD was categorized...
Articles
Effects of tumour necrosis factor-α in the human forearm: blood flow and endothelin-1 release
Available to PurchaseJ.N. PATEL, A. JAGER, C. SCHALKWIJK, R. CORDER, J.A. DOUTHWAITE, J.S. YUDKIN, S.W. COPPACK, C.D.A. STEHOUWER
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (4): 409–415.
Published: 09 September 2002
... are unclear. The aim of the present study was to determine the effects of intra-arterial TNF-α on ET-1 spillover, vascular tone and endothelial function in the healthy human forearm. Brachial arterial and deep venous blood samples, forearm plasma flow measurements and blood flow responses to acetylcholine...
Articles
Coronary responses to endothelin-1 and acetylcholine during partial coronary ischaemia and reperfusion in anaesthetized goats
Available to PurchaseMaria Angeles MARTÍNEZ, Nuria FERNÁNDEZ, Luis MONGE, Angel Luis GARCÍA-VILLALÓN, Elena SANZ, Godofredo DIÉGUEZ
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (s2002): 194S–197S.
Published: 01 September 2002
...Maria Angeles MARTÍNEZ; Nuria FERNÁNDEZ; Luis MONGE; Angel Luis GARCÍA-VILLALÓN; Elena SANZ; Godofredo DIÉGUEZ To examine coronary reactivity to acetylcholine and endothelin-1 (ET-1) during partial ischaemia and reperfusion, flow in the left circumflex coronary artery was measured...
Articles
Effect of lowering tumour necrosis factor-α on vascular endothelial function in Type II diabetes
Available to PurchaseWilliam BILSBOROUGH, Gerard O'DRISCOLL, Kim STANTON, Rukshen WEERASOORIYA, Lawrence DEMBO, Roger TAYLOR, Daniel GREEN
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (2): 163–169.
Published: 17 July 2002
... of 8weeks pentoxifylline and 8weeks placebo. Endothelium-dependent and-independent vasodilation in resistance arteries was assessed via bilateral forearm venous occlusion plethysmography during intra-brachial infusions of acetylcholine (ACh), sodium nitroprusside (SNP) and N G -monomethyl- l -arginine ( l...
Articles
Acute haemodynamic effects of lipolysis-induced increase of free fatty acids in healthy men
Available to PurchaseMark T. KEARNEY, Philip J. CHOWIENCZYK, Sally E. BRETT, Angela SUTCLIFFE, James M. RITTER, Ajay M. SHAH
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (5): 495–500.
Published: 10 April 2002
... by venous occlusion plethysmography during brachial artery infusions of saline, acetylcholine and nitroprusside before, and at 1 and 2h. Lipid/heparin infusion had no significant effect on vasodilation to nitroprusside but progressively increased responses to acetylcholine (from 6.3±2.0 during 30 μ gċmin -1...
Articles
Vascular KATP channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes
Available to PurchaseE.J. ABBINK, P. PICKKERS, A. Jansen VAN ROSENDAAL, J.A. LUTTERMAN, C.J. TACK, F.G.M. RUSSEL, P. SMITS
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (3): 307–314.
Published: 08 February 2002
...) in response to intra-arterially administered diazoxide, acetylcholine and dipyridamole and to forearm ischaemia was measured. The diazoxide-mediated increase in the forearm blood flow ratio (infused/control arm) was significantly less pronounced after glibenclamide than after acarbose (290±58% and 561±101...
Articles
Diminished skin blood flow in Type I diabetes: evidence for non-endothelium-dependent dysfunction
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (1): 59–64.
Published: 24 May 2001
.... Patients and matched controls were studied after an overnight fast. SBF was determined with laser Doppler perfusion imaging before and after iontophoresis of acetylcholine (Ach; endothelium-dependent) and sodium nitroprusside (SNP; endothelium-independent). Basal SBF did not differ significantly between...
Articles
Supplemental oxygen does not modulate responses to acetylcholine or ascorbic acid in the forearm of patients with congestive heart failure
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Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (1): 57–63.
Published: 14 June 2000
... reduces nitric oxide (NO) bioavailability, using endothelium-dependent (acetylcholine) and -independent (phentolamine) vasodilators, and the antioxidant ascorbic acid. Ten patients (nine male and one female) with primary left ventricular failure participated in the study. Forearm venous occlusion...
Articles
Androgen deprivation facilitates acetylcholine-induced relaxation by superoxide anion generation
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Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (6): 625–631.
Published: 29 October 1999
...Mercedes FERRER; Nuria TEJERA; Jesús MARÍN; Gloria BALFAGÓN The aim of the present study was to assess the role of superoxide anions in the relaxation induced by acetylcholine (ACh) in aortic segments from male rats, and to investigate if their production is altered by sex hormone deprivation...
Articles
Basal nitric oxide production is impaired in offspring of patients with essential hypertension
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (2): 141–147.
Published: 16 June 1999
...A. S. McALLISTER; A. B. ATKINSON; G. D. JOHNSTON; D.R. HADDEN; P. M. BELL; D. R. McCANCE There is considerable evidence that endothelium-dependent nitric oxide (NO)-mediated vasodilatation in response to acetylcholine is impaired in essential hypertension, whereas the endothelium-independent...
Articles
Portal hypertension increases vasoconstrictor responsiveness of rat aorta
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 96 (1): 41–47.
Published: 01 January 1999
... of gastrointestinal vasodilator hormones into the systemic circulation or to diminished responsiveness of Key words : acetylcholine, aorta, noradrenaline, phenylephrine, portal hypertension, Sprague Dawley rat, Wistar rat. Correspondence: Professor J. R. Docherty. the systemic vasculature to endogenous...
Articles
Influences of carvedilol treatment on the effects of acetylcholine on regional haemodynamics in the spontaneously hypertensive rat
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (3): 303–309.
Published: 01 September 1998
... accordingly. Correspondence : Dr Sven-Olof Granstam. 5 1 1998 18 3 1998 14 4 1998 The Biochemical Society and the Medical Research Society © 1998 1998 acetylcholine blood flow carvedilol haemodynamics hypertension spontaneously hypertensive rat 303Clinical Science...
Articles
Beneficial effect of vitamin E administration on nitric oxide function in subjects with hypercholesterolaemia
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (3): 361–367.
Published: 01 September 1998
.... of vitamin E twice daily for 4 weeks. Endothelium-dependent and -independent vasodilatation were assessed by intrabrachial infusion of acetylcholine and sodium nitroprusside, and forearm blood flow was measured by strain-gauge plethysmography. Basal ·NO function was assessed by infusion of N G -monomethyl- l...
Articles
Influence of Mode of Contraction on the Mechanism of Acetylcholine-Mediated Relaxation of Coronary Arteries from Normotensive and Spontaneously Hypertensive Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (3): 231–238.
Published: 01 March 1998
...Stuart J. Bund 1. Endothelium-dependent acetylcholine-mediated relaxations of small coronary arteries (∼200 μm internal diameter) from 20 weeks old spontaneously hypertensive rats (SHR) and normotensive Wistar—Kyoto (WKY) controls were compared under pressurized no-flow conditions after...
Articles
Lack of Effect of Vitamin E on l-Arginine-Responsive Endothelial Dysfunction in Patients with Mild Hypercholesterolaemia and Coronary Artery Disease
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (2): 129–134.
Published: 01 February 1998
... placebo ( n = 10) or vitamin E, 400 i.u. daily, ( n = 10) for 8 weeks. Endothelium-dependent and independent vasodilatation within forearm vasculature was assessed by brachial artery infusion of acetylcholine (co-infused with saline vehicle and l-arginine) and nitroprusside before and after...
Articles
Role of Nitric Oxide towards Vasodilator Effects of Substance P and ATP in Human Forearm Vessels
Available to PurchaseMasanari Shiramoto, Tsutomu Imaizumi, Yoshitaka Hirooka, Toyonari Endo, Takashi Namba, Jun-Ichi Oyama, Kiyoshi Hironaga, Akira Takeshita
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (2): 123–131.
Published: 01 February 1997
...Masanari Shiramoto; Tsutomu Imaizumi; Yoshitaka Hirooka; Toyonari Endo; Takashi Namba; Jun-Ichi Oyama; Kiyoshi Hironaga; Akira Takeshita 1. It has been shown in animals that substance P as well as acetylcholine releases endothelium-derived nitric oxide and evokes vasodilatation and that ATP-induced...
Articles
Comparison of Forearm Vasodilatation to Substance P and Acetylcholine: Contribution of Nitric Oxide
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Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (2): 133–138.
Published: 01 February 1997
...David E. Newby; Nicholas A. Boon; David J. Webb 1. Forearm blood flow responses to incremental challenges of acetylcholine and substance P, administered via the brachial artery, were measured by venous occlusion plethysmography in eight subjects in the presence of saline, the nitric oxide synthase...
Articles
Small Artery Structural Alterations of Patients with Microvascular Angina (Syndrome X)
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (6): 739–743.
Published: 01 December 1996
.... Morphological measurements revealed a significant increase in media thickness/lumen diameter ratio in arteries from patients with Syndrome X. Contractile responses to U46619 were similar in arteries from patients and control subjects. Endothelium-dependent relaxation induced with acetylcholine and bradykinin...
Articles
Vascular Hyporesponsiveness in Aortic Rings from Cirrhotic Rats: Role of Nitric Oxide and Endothelium
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (6): 733–738.
Published: 01 December 1996
... and that of the endothelium in the response to phenylephrine and acetylcholine of isolated aortic rings from chronic bile duct-ligated (29 days) rats and their corresponding controls. Experiments were performed in rings with or without endothelium, in rings pretreated with N -ω-nitro-l-arginine methyl ester (10 −4 mol/l...
Articles
Effect of Angiotensin-Converting Enzyme Inhibitors on Resistance Artery Structure and Endothelium-Dependent Relaxation in Two-Kidney, One-Clip Goldblatt Hypertensive and Sham-Operated Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (1): 21–29.
Published: 01 January 1996
... rats were treated with either perindopril (1 mg day −1 kg −1 ) or quinapril (3 or 30mg day −1 kg −1 ). After 6 weeks mesenteric resistance arteries were mounted in a myograph for measurements of vascular structure. The endothelium-dependent relaxation response to acetylcholine and bradykinin...
Articles
Selective Impairment of Acetylcholine-Mediated Endothelium-Dependent Relaxation in Isolated Resistance Arteries of the Streptozotocin-Induced Diabetic Rat
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (5): 519–524.
Published: 01 May 1995
...-induced diabetic rats and age-matched controls were investigated using two endothelium-dependent vasodilators, bradykinin and acetylcholine, and the endothelium-independent vasodilator sodium nitroprusside. The contractile responses to the α 1 -adrenergic agonist phenylephrine were also studied. 2...
Articles
Involvement of Nitric Oxide in the Vasodilatory Response to Parathyroid Hormone-Related Peptide in the Isolated Rabbit Kidney
Available to PurchaseUmberto Simeoni, Thierry Massfelder, Christian Saussine, Clément Judes, Jean Geisert, Jean-Jacques Helwig
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (3): 245–249.
Published: 01 March 1994
... rabbit kidney perfused in the presence of indomethacin (10 μmol/l) and preconstricted with noradrenaline (7.2 nmol/min). 2. Under control conditions, bolus administrations of acetylcholine (10 μmol/l), an NO-dependent renal vasodilator, verapamil (0.1 mmol/l), an NO-independent renal vasodilator...
Articles
Effect of N G -Monomethyl-l-Arginine on Endothelium-Dependent Relaxation of Human Subcutaneous Resistance Arteries
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (3): 273–278.
Published: 01 September 1990
... relaxing factor synthesis, caused concentration-dependent but only partial inhibition of maximal relaxation induced by acetylcholine in human subcutaneous resistance arteries. 3. The inhibitory action of N G -monomethyl-l-arginine on acetylcholine-induced maximal relaxation was partially reversed...
Articles
Biphasic response to acetylcholine in human veins in vivo : the role of the endothelium
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 78 (1): 101–104.
Published: 01 January 1990
...Joe Collier; Patrick Vallance 1. The dose-response to acetylcholine has been examined in dorsal hand veins of healthy volunteers before and after removal of the endothelium. 2. Measurements were made in single dorsal hand veins during local infusions of acetylcholine. The vein was irrigated...
Articles
Modulation of the Baroreceptor Reflex by Angiotensin II and other Vasoactive Drugs in Anaesthetized Greyhounds
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Journal:
Clinical Science
Clin Sci (Lond) (1980) 58 (1): 7–13.
Published: 01 January 1980
...J. D. Marker; T. S. Miles; G. C. Scroop 1. The effects of vascular infusions of acetylcholine, angiotensin II, noradrenaline and prostaglandin F 2α on the baroreceptor reflex were studied in the anaesthetized greyhound. 2. Vertebral artery infusions of low doses of angiotensin II...
Articles
Influence of Cortical Plasma Transit-Time on p -Aminohippurate Extraction during Induced Renal Vasodilatation in Anaesthetized Dogs
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Journal:
Clinical Science
Clin Sci (1972) 43 (3): 401–411.
Published: 01 September 1972
... by an indicator-dilution technique. 2. Increases in renal blood flow during graded intravenous iso-osmotic saline or hyperosmotic mannitol infusions and during renal arterial infusions of acetylcholine or prostaglandin E 1 were consistently associated with reduced E PAH . 3. The cortical fraction of renal blood...
